A direct C–H bond phosphonation of quinoxalin-2(1<italic>H</italic>)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed.

A novel sp2−sp3 hybridized mixed diboron and its reactivity on the copper-catalyzed β-boration of α,β-unsaturated conjugated compounds to afford corresponding β-borated is reported. The presence sp3-hybridized boron provides a mild condition in absence phosphine base additives. Finally, our investigations demonstrate that sp2-hybridized selectively transferred β-carbon substrates.

A novel sp2–sp3 diboron reagent has been developed for the copper-catalyzed β-boration of α,β-unsaturated conjugated compounds. The reaction proceeds under mild conditions with various substrates, i.e., esters, ketones, nitriles, ynones, amides, and aldehydes, in absence additives such as phosphine sodium tert-butoxide to provide β-borylhomoenolates good excellent yields. presence an sp3-hybridized boron center, unambigously confirmed by X-ray crystallography, sufficiently activates...

A novel, efficient and practical method for copper-catalysed oxidative C-3 amination of quinoxalin-2(1<italic>H</italic>)-ones with primary or secondary amines as the nitrogen sources has been developed.

S1P (sphingosine 1-phosphate) is a pleiotropic lipid mediator involved in numerous cellular and physiological functions. Of note among these are cell survival migration, as well lymphocyte trafficking. S1P, which exerts its effects via five GPCRs (G-protein-coupled receptors) (S1P1–S1P5), formed by the action of two SphKs kinases). Although SphK1 more intensively studied isotype, SphK2 unique it nuclear localization has been reported to oppose some actions ascribed SphK1. several scaffolds...

Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that acts as ligand for five G-protein coupled receptors (S1P1–5) whose downstream effects are implicated in variety of important pathologies including sickle cell disease, cancer, inflammation, and fibrosis. The synthesis S1P catalyzed by sphingosine kinase (SphK) isoforms 1 2, hence, inhibitors this phosphorylation step pivotal understanding the physiological functions SphKs. To date, SphK1 2 with potency, selectivity, vivo...

The biological functions of lipids largely depend on their chemical structures. position and configuration C=C bonds are two the essential attributes that determine structures unsaturated lipids. However, simultaneous identification both remains challenging. Here, we develop a bifunctional visible-light-activated photocycloaddition-photoisomerization reaction system, which enables dual-resolving positional geometric isomerism in when combines with liquid chromatography-mass spectrometry....

Accurate lipid quantification is essential to revealing their roles in physiological and pathological processes. However, difficulties the structural resolution of isomers hinder further accurate quantification. To address this challenge, we developed a novel stable-isotope N-Me aziridination strategy that enables simultaneous qualification unsaturated isomers. The one-step introduction 1-methylaziridine structure not only serves as an activating group for C═C bond facilitate positional...

Stable phospha- and arsaalkenes were used to synthesize polymers containing unsaturated P[double bond, length as m-dash]C As[double moieties. The composition, chemical environment, structure, optical, electronic properties of the monomers elucidated. incorporation heteroatom-carbon double bonded units efficiently perturbs optoelectronics solid state features both monomeric polymeric scaffolds. Proof-of principle work supports their responsive character through post-functionalisation...

CoB/Ni-foam was directly formed on a Ni-foam substrate using the electroless plating method. A membraneless DBFC with (7EP) as an anode showed maximum power density of 230 mW cm⁻².

The discovery of highly enantioselective catalysts and elucidating their generality face great challenges due to the complex multidimensional chemical space asymmetric catalysis inefficient screening methods. Here, we develop a general strategy for ultra-high-throughput mapping by escaping time-consuming chiral chromatography separation. ultrafast ( ~ 1000 reactions/day) accurate (median error < ±1%) analysis enantiomeric excess are achieved through ion mobility-mass spectrometry combines...

A series of chiral N,O-ligands derived from a 1,2-dihydroimidazo[1,2-a]quinolone motif have been evaluated for the asymmetric 1,3-dipolar cycloaddition azomethine ylides with novel dipolarophile β-phthalimidonitroethene. newly designed DHIPOH ligand 7c bearing 1-methyl and 4-iodo substituents was found to significant "synergistic steric effects" consequently afforded corresponding 4-nitro-3-aminopyrrolidines excellent diastereo- (dr up 98:2) enantio selectivities (ee 99%). Subsequent Raney...

An imidazolium-modified chiral rhodium/diamine-functionalized periodic mesoporous organosilica is developed, which greatly promotes asymmetric transfer hydrogenation of α-haloketones and benzils in aqueous medium.

We demonstrate that aryltriazenes can promote three distinctive types of C–H functionalization reactions, allowing the preparation complex benzene molecules with diverse substitution patterns. 2-Triazenylbenzaldehydes are shown to be efficient substrates for Rh(I)-catalyzed intermolecular alkyne hydroacylation reactions. The resulting triazene-substituted ketone products then undergo either a Rh(III)-catalyzed activation, or an electrophilic aromatic reaction, achieving...

Rhodium-catalyzed alkyne hydroacylation using alkyl β-S-aldehydes, enantioselective rhodium-catalyzed aryl boronic acid conjugate addition, and sulfide elimination are combined in sequence to provide β′-aryl enones. The reaction is efficient delivers highly functionalized products with excellent levels of enantiocontrol. Good variation the three components demonstrated. corresponds formal regio- monoconjugate addition acids dienones.

Abstract The first and enantioselective total synthesis of (+)‐plumisclerin A, a novel unique complex cytotoxic marine diterpenoid, has been accomplished. Around the central cyclopentane anchorage, sequential ring‐formation protocol was adopted to generate characteristic tricycle[4.3.1.0 1,5 ]decane trans ‐fused dihyrdopyran moiety. Scalable La III ‐catalyzed Michael reaction, palladium(0)‐catalyzed carbonylation SmI 2 ‐mediated radical conjugate addition were successfully applied in...

A visible-light-driven radical silylative cyclization of aza-1,6-dienes featuring an acrylonitrile or acrylate moiety and electron-neutral olefin was developed, which allows for stereoselective synthesis densely functionalized piperidines in a highly atom-economical manner. Depending on the substitution pattern olefin, poor-to-excellent diastereoselectivity observed. It suggested that 6-exo-trig initiated by chemoselective addition silyl toward electron-deficient geometry remaining is...

Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex RuCl2(PPh3)3, which results in series bicyclo[3.1.0]hexyl allene derivatives moderate to excellent yields. Mechanistic investigation indicates that in-situ-generated vinylidene undergoes site-selective metathesis process provide allenyl carbene, can be intramolecularly trapped by pendent C=C bond enyne through [2 + 2] cycloaddition/metal elimination process.