A5005476961- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Viral gastroenteritis research and epidemiology
- Amoebic Infections and Treatments
- Herpesvirus Infections and Treatments
- Coccidia and coccidiosis research
- SARS-CoV-2 and COVID-19 Research
- Social Work Education and Practice
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Grief, Bereavement, and Mental Health
- Animal Virus Infections Studies
- interferon and immune responses
- Mental Health Treatment and Access
- Dermatological diseases and infestations
- Higher Education and Employability
- Innovative Teaching Methods
- Identification and Quantification in Food
- Parasite Biology and Host Interactions
- Career Development and Diversity
- Virus-based gene therapy research
- Pregnancy and preeclampsia studies
- Helminth infection and control
- Viral Infections and Immunology Research
- Genetic diversity and population structure
South China Agricultural University
2017-2025
Washington University in St. Louis
2024-2025
China University of Political Science and Law
2025
Guangxi Normal University
2025
Guangdong Pharmaceutical University
2025
Key Laboratory of Guangdong Province
2018-2021
Chinese University of Hong Kong
2017-2021
South China Normal University
2020
Ministry of Agriculture and Rural Affairs
2020
National Taiwan University Hospital
2007
The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. new responsible for this outbreak—severe acute respiratory syndrome 2 (SARS-CoV-2)—shares high sequence identity SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the reservoir host variety coronaviruses3,4, it remains unknown whether SARS-CoV-2 has additional species. Here we show that which name pangolin-CoV, isolated from Malayan pangolin 100%, 98.6%, 97.8% 90.7% amino...
Abstract The outbreak of 2019-nCoV in the central Chinese city Wuhan at end 2019 poses unprecedent public health challenges to both China and rest world 1 . new coronavirus shares high sequence identity SARS-CoV a newly identified bat 2 While bats may be reservoir host for various coronaviruses, whether has other hosts is still ambiguous. In this study, one isolated from Malayan pangolins showed 100%, 98.2%, 96.7% 90.4% amino acid with E, M, N S genes, respectively. particular,...
Blue fluorescent carbon dots were synthesized via a hydrothermal method using glutathione and sodium citrate, dot-based sensing platform was constructed to realize in vivo of Fe 3+ distribution plant species.
Zoonotic Cryptosporidium parvum infections are mainly caused by IIa and IId subtypes. As most biological characterizations have been performed on subtypes, the genetic characteristics of subtypes in China not clear. We evaluated infection isolates interferon-γ-knockout mice using qPCR to quantify oocyst shedding, histological examination monitor pathological changes comparative genomic analyses identify infectivity virulence-associated differences. Compared with reference isolate, infected...
In the era of smart agriculture, precise labeling and recording growth information in plants pose challenges for modern agricultural production. This study introduces strontium aluminate particles coated with H
In recent years, incentivising civil servants to work has been at the heart of future service reforms in many countries. To investigate micro-mechanism and its boundary conditions grassroots servants' competency on their individual dynamic, this study explores influence mediating role occupational resilience moderating organizational fault-tolerant climate. Data were obtained from 667 China analyzed with regression analyses by PROCESS macro. The results showed that can significantly...
Sensing of cytosolic, double-stranded (ds) DNA or dsRNA molecules derived from microbial endogenous sources triggers cell-intrinsic innate immunity, but sensors recognizing both cytosolic dsDNA and are sparsely reported. Here we find that full-length human SAMD9 protein directly binds to synthetic viral dsRNA. Overexpression various vertebrate species leads robust production interferons pro-inflammatory cytokines. By contrast, loss impairs the interferon responses stimulation in multiple...
To analyze the policies related to mental illness in China, concentrate on deficiencies configuration of policy tools, and provide reference suggestions for government improve protection policies. Using tools method, we constructed a three-dimensional model "policy - service providers objectives," statistically analyzed characteristics reasonableness each dimension cross-fertilization dimensions. The has largest proportion environmental 46.71%. With 28 25.29% supply side demand tools. public...
ABSTRACT Toxoplasma gondii bradyzoites play a critical role in pathology due to their long-term persistence intermediate hosts and potential reactivate, resulting severe diseases immunocompromised individuals. Currently, there is no effective treatment for eliminating bradyzoites. Hence, better vitro models of T. bradyzoite development would facilitate identification therapeutic targets Herein, we characterized natural isolate , called Tg68, which showed slower replication tachyzoites,...
Very little is known about the process of meiosis in apicomplexan parasite Cryptosporidium despite essentiality sex its life cycle. Most cell lines only support asexual growth parvum ( C . ), but stem derived intestinal epithelial cells grown under air-liquid interface (ALI) conditions sexual To examine chromosomal dynamics during , we generated two transgenic parasites that were fluorescently tagged with mCherry or GFP on chromosomes 1 5, respectively. Infection ALI cultures Ifngr1 -/- mice...
The aim of this study was to derive a competency framework from the perspective Chinese experts in social work, and reveal reasons for these particular choices. Working reference professional competencies that have been identified by USA, England Hong Kong, twenty academics, fourteen Directors/Deputy Directors fifteen senior practitioners individually chose those they perceived as important consensus reached accordance with fuzzy Delphi method. It discovered should be constituted twenty-four...
The role of species-specific immunity in infection patterns Cryptosporidium spp. humans and farm animals is not well understood. In the present study, dynamics infections a natural cryptosporidiosis model was examined using genotyping, subtyping whole genome sequencing tools. cross-sectional survey 934 dairy cattle on one farm, marked age-associated differences distribution species C. bovis subtypes were observed. closely followed longitudinal birth cohort study 81 calves over 9-month...
Some researchers have reported that Toxoplasma gondii can cause serious reproductive impairment in male animals. Specifically, T. destroy the quality of sperm epididymis, which affects their sexual ability. However, among such studies, none investigated transcriptome. Therefore, to investigate relationship between and maturation, we infected mice with prugniaud (PRU) strain performed transcriptome sequencing epididymis.Compared control group, 431 upregulated 229 downregulated differentially...
Sprague Dawley rats and Kunming (KM) mice are artificially infected with type II Toxoplasma gondii strain Prugniaud (Pru) to generate toxoplasmosis, which is a fatal disease mediated by T. invasion of the central nervous system (CNS) unknown mechanisms. The aim explore mechanism differential susceptibility infection. Therefore, strategy isobaric tags for relative absolute quantitation (iTRAQ) established identify differentially expressed proteins (DEPs) in rats' mice's brains compared...
bradyzoites play a critical role in pathology due to their long-term persistence intermediate hosts and potential reactivate, resulting severe diseases immunocompromised individuals. Currently there is no effective treatment for eliminating bradyzoites. Hence, better