A5077972068- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Multiple Sclerosis Research Studies
- Neurological Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Radiomics and Machine Learning in Medical Imaging
- Olfactory and Sensory Function Studies
- Cerebrospinal fluid and hydrocephalus
- Hallucinations in medical conditions
- Atomic and Subatomic Physics Research
- Systemic Lupus Erythematosus Research
- Glioma Diagnosis and Treatment
- Neural dynamics and brain function
- Advanced Chemical Sensor Technologies
- Peripheral Neuropathies and Disorders
- Health, Environment, Cognitive Aging
- Cerebral Venous Sinus Thrombosis
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2011-2024
HKU-Pasteur Research Pole
2017-2024
Queen Mary Hospital
2009-2022
University of Oxford
2017
Epsom and St Helier University Hospitals NHS Trust
2017
York University
2014-2015
Queen Mary University of London
2012
Research Network (United States)
2011
Shatin Hospital
2007
In patients with TIA and ischemic stroke, we validated the total small vessel disease (SVD) score by determining its prognostic value for recurrent stroke.Two independent prospective studies were conducted, one comprising predominantly Caucasian TIA/ischemic stroke (Oxford Vascular Study [OXVASC]) Chinese (University of Hong Kong [HKU]). Cerebral MRI was performed assessed lacunes, microbleeds, white matter hyperintensities (WMH), perivascular spaces (PVS). Predictive SVD risk determined...
Abstract Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet it can be cost-prohibitive given the high installation, maintenance and operation costs of machinery. There are approximately seven scanners per million inhabitants over 90% concentrated high-income countries. We describe an ultra-low-field brain MRI scanner that operates using standard AC power outlet low cost to build. Using permanent 0.055 Tesla Samarium-cobalt magnet deep learning for cancellation...
<b><i>Background:</i></b> Imaging of the carotid arteries is important for evaluation patients with ischemic stroke or TIA. CT angiography (CTA) head and neck readily available can be part routine imaging patients. To evaluate accuracy CTA, authors compared degree stenosis found using CTA digital subtraction (DSA) in consecutive during a 3-year period. <b><i>Methods:</i></b> The included all interpretable DSA cervical from April 2000 to November 2002 at single academic medical center. This...
Abstract Background: Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia mortality. Aberrant default mode network (DMN) is associated with other psychoses. Here, we tested hypothesis that DMN dysfunction contributes to VH PD. Methods: Resting state functional data was acquired from individuals PD (PDVH) without (PDnonVH), matched for levodopa drug equivalent dose, a healthy control group (HC). Independent component...
Perivascular spaces (PVSs) are considered markers of small vessel disease. However, their long-term prognostic implications in transient ischemic attack/ischemic stroke patients unknown. Ethnic differences PVS prevalence also unknown.Two independent prospective studies were conducted, 1 comprising predominantly whites with (OXVASC [Oxford Vascular] study) and Chinese (University Hong Kong). Clinical imaging correlates, for death, ethnic basal ganglia (BG) centrum semiovale (CS) PVSs studied...
The link between non-demented type 2 diabetes mellitus (T2DM) and different types of cognitive impairment is controversial. By controlling for co-morbidities such as cerebral macrovascular microvascular changes, atrophy, amyloid burden, hypertension or hyperlipidemia, the current study investigated blood flow T2DM individuals compared to cognitively impaired subjects recruited from a memory clinic. 15 healthy control (71.8 ± 6.1 years), 18 (62.5 3.7 well 8 Subjective Cognitive Decline (69.5...
Visual hallucinations carry poor prognosis in Parkinson's disease. Here we tested the hypothesis that hippocampus and visuospatial memory impairment play a central role pathology of PD with visual hallucinations. Multimodal magnetic resonance imaging brain was carried out 12 people hallucinations; 15 individuals without 14 healthy controls. Age, gender, cognitive ability, education level were matched across three groups. patients taking dopaminergic medication. Hippocampal volume, shape,...
QUASAR arterial spin labeling (ASL) was used to investigate the role of vascular impairment in Alzheimer's disease (AD). We hypothesized that hemodynamic parameters monitoring cerebrovascular integrity, i.e., cerebral blood flow (CBF), b
Abstract Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact almost all adults over 60 years old develop small vessel disease (SVD). The wide range of neuropathologies could only explain up to 43% variation in age-related cognitive impairment suggests other factors, such as reserve, play role brain’s resilience against aging-related decline. This study aims examine between structural–functional-connectivity coupling (SFC), aging,...
The integrity of structural connectivity in a functional brain network supports the efficiency neural processing within relevant regions. This study aimed to quantitatively investigate short- and long-range fibers, their differential roles lower cognitive aging dementia. Three groups healthy young, older adults patients with Alzheimer's disease (AD) participated this combined magnetic resonance imaging (fMRI) diffusion tensor (DTI) on prospective memory (PM). Short- fiber tracts PM task...
Late stage Parkinson's disease (PD) patients were commonly observed with other non-motor comorbidities such as dementia and psychosis. While abnormal iron level in the substantia nigra was clinically accepted a biomarker of PD, it also suggested that increased deposition could impair brain regions induce symptoms. A new Magnetic Resonance Imaging (MRI) called Quantitative Susceptibility Mapping (QSM) has been found to measure concentration grey matter reliably. In this study, we investigated...
Parkinson's psychosis (PDP) describes a spectrum of symptoms that may arise in disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates PDP have been inconsistent their findings, due to differences study design and limitations scale. Here we use empirical Bayes harmonisation pool together structural imaging data from multiple research groups into large-scale mega-analysis, allowing us identify cortical regions networks involved VH relation...
Olfactory dysfunction (OD) is a common symptom in coronavirus disease 2019 (COVID-19) patients. Moreover, many neurological manifestations have been reported these patients, suggesting central nervous system involvement. The default mode network (DMN) closely associated with olfactory processing. In this study, we investigated the internetwork and intranetwork connectivity of DMN (ON) 13 healthy controls 22 patients presenting COVID-19-related OD using independent component analysis region...
Abstract Purpose: To investigate whether quantitative MRI measures of cervical spinal cord white matter (WM) using diffusion tensor imaging (DTI) in neuromyelitis optica (NMO) differed from controls and correlated with clinical disability. Materials Methods: Ten referred patients 12 healthy volunteers were imaged on a 3 Tesla scanner clinically assessed the Expanded Disability Status Scale (EDSS). Two raters quantified DTI‐derived indices all participants, including fractional anisotropy...
Retrogenesis refers to the phenomenon by which degenerative processes in aging reverse sequence of acquisition development. Although there has been some evidence for brain retrogenesis abnormal aging, e.g., Alzheimer's disease (AD), it not explicitly addressed normal aging. Using diffusion tensor imaging and tractography, we explored effects on integrity white matter (WM) fifty participants, including 18 AD patients, 17 elderly, 15 young adults. Compared with adults, traditional voxel-based...
Quantitative MRI of the hippocampus has been increasingly employed as a biomarker in Alzheimer's disease (AD). We compare voxel-based morphometry (VBM) standard and DARTEL registration with manual hippocampal volumetry AD patients cognitively
Cerebellar dysfunction is associated with neurological soft signs (NSS), which a promising endophenotype for schizophrenia spectrum disorders. However, the relationship between cerebellar-cerebral resting-state functional connectivity (rsFC) and NSS largely unexplored. Moreover, both rsFC have been found to be correlated negative symptoms of schizophrenia. Here, we investigated correlations rsFC, explored their in main dataset, validated significant findings replication dataset. Both...
Background Patients with chronic kidney disease are at increased risk of stroke and frequently have cerebral microbleeds. Whether such patients also encounter an recurrent has not been firmly established. We aimed to determine whether impaired function is associated the stroke, microbleed presence, distribution severity. Methods used pooled data from Microbleeds International Collaborate Network investigate associations function, defined as estimated glomerular filtration rate (eGFR) <60...