A5102808948- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Digestive system and related health
- Nutrition and Health in Aging
- Growth Hormone and Insulin-like Growth Factors
- Colorectal Cancer Screening and Detection
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Bone health and osteoporosis research
- Genetics and Neurodevelopmental Disorders
- Cancer Genomics and Diagnostics
- Advanced Proteomics Techniques and Applications
Zhejiang University
2015-2024
St Vincent's Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Zhejiang Cancer Hospital
2023
Zhejiang Chinese Medical University
2019-2022
Academy of Medical Sciences
2022
Women's Hospital, School of Medicine, Zhejiang University
2019-2022
The University of Texas MD Anderson Cancer Center
2012-2013
Sir Run Run Shaw Hospital
2007
Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for therapy through targeting SRSF6. Design We performed comprehensive analysis expression 311 CRC samples, The Cancer Genome Atlas Gene Expression Omnibus (GEO) database. Functional was vitro vivo . SRSF6-regulated alternative (AS) its binding motif were identified by next-generation RNA-sequencing RNA immunoprecipitation sequencing (RIP-seq),...
// Chen Li 1, 4, * , Jingyu Wang 2, 5, Jianlu Kong 4 Jinlong Tang 3 Yihua Wu 1 Enping Xu Honghe Zhang Maode Lai Department of Pathology, School Medicine, Zhejiang University, Zhejiang, PR China 2 the First Hospital Jiaxing, Second Affiliated Hospital, University Key Laboratory Disease Proteomics Province, 5 Constructing Discipline by Province and Jiaxing City, These authors have contributed equally to this work Correspondence to: Zhang, e-mail: honghezhang@zju.edu.cn Lai, lmp@zju.edu.cn...
Long non-coding RNAs (lncRNAs) function as key molecules in cancer progression. The lncRNA CYTOR plays oncogenic roles multiple types of cancer, yet the detailed molecular mechanisms those remain unknown. aim this study was to investigate clinical significance, biological and interacting partners colorectal (CRC).A systematic comprehensive analysis expression performed 138 CRC samples TCGA GEO databases. Biological investigated through knockdown overexpression vitro vivo. In addition, its...
Our purpose was to investigate the role of SOX9, a novel downstream molecule beta-catenin, in colorectal cancer. Expression SOX9 and beta-catenin detected by immunostaining, quantitative real-time reverse transcription-polymerase chain reaction (Q-PCR), Western blot The correlation between or expression clinicopathologic parameters also analyzed. Immunostaining, Q-PCR, consistently confirmed up-regulation cancer compared with normal mucosa (P < .05). Immunostaining showed more SOX9+ cells...
AbstractInsulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current study, we investigated function of IGFBP7 CRC by transfection studies. We found that could inhibit growth, decrease soft agar colony formation activity and induce apoptosis RKO SW620 cells. Correlation analysis between expression tissue prognosis 218 patients showed high was associated with favourable prognosis. Based on above...
Colorectal cancer (CRC) is one of the most common causes cancer-related death worldwide due to distant metastases. Compelling evidence has reported that epithelial-mesenchymal transition (EMT) involved in promoting invasion and metastasis. However, precise molecular events initiate this complex EMT process remain poorly understood. Here, we showed pleiotropic cytokine interleukin-13 (IL-13) could induce an aggressive phenotype displaying by enhancing expression EMT-promoting factor ZEB1....
Abstract Recent studies have revealed many different long noncoding RNA s (lnc ), however, the investigation for their function and clinical value as tumour biomarkers has scarcely begun. Here, we found that expression of HOTAIRM 1 was reduced in colorectal cancer ( CRC ) tissues compared with matched normal tissues, plasma levels patients were less than controls. The cut‐off point chosen 0.003 a sensitivity 64.00% specificity 76.50% validation set. performance highly comparable to...
The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify AMER1 as a key regulator of ferroptosis. loss causes resistance to in colorectal (CRC) cells. Interestingly, AMER1-deficient CRC cells preferentially form distant metastases, while AMER1-naive mainly invade lymph nodes. Moreover, the inhibitor liproxstatin-1 effectively promotes hematogenous transfer Mechanistically, binds SLC7A11 ferritin light chain (FTL) recruits β-TrCP1/2, which degrade FTL by...
Adenoma is the major precursor lesion of colorectal cancer, one most common cancers worldwide. The elucidation molecular mechanism underlying adenoma essential for early detection, prevention, and intervention cancer. Using a combination two-dimensional gel electrophoresis mass spectrometry, we identified 27 differentially expressed proteins in adenoma, compared with matched normal mucosa cancer tissue. Seventeen were upregulated six downregulated when same individual-matched mucosa. Four...
Barrett's esophagus (BE) is a precursor of esophageal adenocarcinoma (EAC). To identify novel tumor suppressors involved in carcinogenesis and potential biomarkers for the malignant progression BE, we performed genome-wide methylation profiling BE EAC tissues. Using Illumina's Infinium HumanMethylation27 BeadChip microarray, examined status 27 578 CpG sites 94 normal (NE), 77 117 tissue samples. The overall within islands was higher, but outside lower tissues than NE Hierarchical clustering...
Abstract BACKGROUND The fibroblast growth factor (FGF) and FGF receptor (FGFR) axis plays a critical role in tumorigenesis, but little is known of its influence ovarian cancer. We sought to determine the association genetic variants pathway with risk, therapeutic response, survival patients METHODS matched 339 non-Hispanic white cancer cases 349 healthy controls genotyped them for 183 single-nucleotide polymorphisms (SNPs) from 24 (fibroblast factor) FGFR receptor) genes. Genetic...
Aberrant expression of forkhead box C1 (FOXC1) promotes tumor metastasis in multiple human malignant tumors. However, the upstream modulating mode and downstream molecular mechanism FOXC1 colorectal cancer (CRC) remain unclear. Herein we describe a systematic analysis prognosis CRC performed on our clinical data public databases, which indicated that upregulation samples was significantly associated with poor prognosis. knockdown inhibited migration invasion, whereas overexpression caused...
To identify proteins with colorectal cancer-specific regulation, comparative 2-DE of individual-matched normal and neoplastic tissue specimens was performed. We found 15 protein spots concordantly increased 20 decreased intensity in tumor (expression regulation more than fivefold). Nine these were identified by MS/MS. Interestingly, one the proteins, which exhibited a marked down-regulation cancer tissues, recently endocrine cell-expressed secretagogin. The reduction secretagogin content...
BACKGROUND Oral premalignant lesions (OPLs) are precursors of oral squamous cell carcinoma (OSCC). Short telomeres in peripheral blood leukocytes (PBLs) associated with increased risks several cancers. However, it is unclear whether short leukocyte telomere length (LTL) predisposes individuals to OPL and OSCC. METHODS LTL was measured PBLs from 266 patients who had a diagnosis either (N = 174) or OSCC 92) 394 age‐matched sex‐matched controls. The association between the risk OSCC, as well...
Abstract Matrix metalloproteinase‐2 (MMP‐2) and ‐9 (MMP‐9) play an important role in cancer initiation, invasion, metastasis. The aim of this study was to investigate whether common genetic variants these two key MMPs are associated with the development progression colorectal a Chinese population. We detected MMP‐2‐790T/G, ‐955A/C, ‐1575G/A, MMP‐9‐1562 C/T polymorphisms 126 patients matched normal controls by PCR‐denaturing high‐performance liquid chromatography (DHPLC) or PCR‐restriction...