A5089500965- Cytokine Signaling Pathways and Interactions
- Magnetic and transport properties of perovskites and related materials
- Bioactive Compounds and Antitumor Agents
- Hematopoietic Stem Cell Transplantation
- Computational Drug Discovery Methods
- interferon and immune responses
- Synthesis and biological activity
- RNA Research and Splicing
- Surface Roughness and Optical Measurements
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Shape Memory Alloy Transformations
- Plant nutrient uptake and metabolism
- Immune Cell Function and Interaction
- Medicinal Plant Pharmacodynamics Research
- Plant Stress Responses and Tolerance
- ZnO doping and properties
- Cancer Mechanisms and Therapy
- Heusler alloys: electronic and magnetic properties
- Asphalt Pavement Performance Evaluation
- Ga2O3 and related materials
- Growth Hormone and Insulin-like Growth Factors
- Ginger and Zingiberaceae research
- X-ray Diffraction in Crystallography
- Thermal Expansion and Ionic Conductivity
Kingmed Diagnostics
2024-2025
China Pharmaceutical University
2016-2025
Fujian University of Traditional Chinese Medicine
2025
State Key Laboratory of Natural Medicine
2017-2024
University of Nottingham Ningbo China
2024
China Academy of Railway Sciences
2020-2024
Shanghai University of Electric Power
2016-2023
Nanjing University of Chinese Medicine
2023
Shandong Agricultural University
2021-2023
Institute of Hematology & Blood Diseases Hospital
2018-2022
Cytosolic DNA activates cGAS (cytosolic sensor cyclic AMP-GMP synthase)-STING (stimulator of interferon genes) signaling, which triggers and inflammatory responses that help defend against microbial infection cancer. However, aberrant cytosolic self-DNA in Aicardi-Goutière's syndrome constituently active gain-of-function mutations STING STING-associated vasculopathy with onset infancy (SAVI) patients lead to excessive type I interferons proinflammatory cytokines, cause difficult-to-treat...
Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for therapy through targeting SRSF6. Design We performed comprehensive analysis expression 311 CRC samples, The Cancer Genome Atlas Gene Expression Omnibus (GEO) database. Functional was vitro vivo . SRSF6-regulated alternative (AS) its binding motif were identified by next-generation RNA-sequencing RNA immunoprecipitation sequencing (RIP-seq),...
Leucine aminopeptidase (LAP) is a kind of proteolytic enzymes and associated closely with pathogenesis cancer liver injury. Accurate detection LAP activity high sensitivity selectivity imperative to detect its distribution dynamic changes for understanding LAP's function early diagnosing the disease states. However, fluorescent in living systems challenging. To date, rarely probes have been reported imaging vivo. In this study, novel probe (TMN-Leu) was developed by conjugating near-infrared...
Abstract Background Drought is one of the main concerns worldwide and restricts development agriculture. Silicon improves drought resistance plants, but underlying mechanism remains unclear. Results We sequenced transcriptomes both control silicon-treated peach seedlings under stress to identify genes or gene networks that could be managed increase tolerance seedlings. Peach ( Prunus persica ) were used analyse effects silicon on plant growth physiological indexes related stress. The results...
As a novel protein knockdown tool, proteolysis targeting chimeras (PROTACs) can induce potent degradation of target proteins by hijacking E3 ubiquitin ligases. However, the uncontrollable disruption PROTACs is prone to cause "off-target" toxicity after systemic administration. Herein, we designed photocaged-PROTAC (phoBET1) and loaded it in UCNPs-based mesoporous silica nanoparticles (UMSNs) construct NIR light-activatable PROTAC nanocage (UMSNs@phoBET1) for controllable degradation. Upon...
Introduction Chronic injury to the rectus femoris muscle induces and exacerbates progression of knee osteoarthritis (KOA). However, lesion characteristics in KOA at different stages have not been fully characterized. The aim this study was analyze pattern investigate mechanism by which ultrasound-guided acupotomy operations can prevent control KOA. Methods Early, middle, late-stage rabbit models were constructed using modified Videman method. Ultrasonography used record elastic modulus...
Constitutive activation of signal transducer and activator transcription 3 (STAT3) has been validated as an attractive therapeutic target for cancer therapy. To stop both STAT3 dimerization, a viable strategy is to design inhibitors blocking its SH2 domain phosphotyrosine binding site that responsible actions. A new fragment-based drug (FBDD) strategy, in silico site-directed FBDD, was applied this study. designed novel compound,...
Nowadays, simultaneous inhibition of multiple targets through drug combination is an important anticancer strategy owing to the complex mechanism behind tumorigenesis. Recent studies have demonstrated that histone deacetylases (HDACs) will lead compensated activation a notorious cancer-related target, signal transducer and activator transcription 3 (STAT3), in breast cancer cascade, which probably limits anti-proliferation effect HDAC inhibitors solid tumors. By incorporating pharmacophore...
ZnO tetrapods and nanorods were synthesized on nanocrystal substrates by a vapor transport process. The source materials ZnCO3 powder powder, respectively, which reduced graphite to yield different amounts of the vapor. catalysts layers prepared successive ionic layer adsorption reaction method. effect structure was investigated. Results showed that for tetropds constituted four pillarlike obtained, while array formed. Possible growth mechanism room-temperature photoluminescence...
Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated could contribute to tumorigenesis medulloblastoma. Numerous studies have demonstrated that inhibition the persistent STAT3 pathway results in decreased proliferation increased apoptosis human cancer cells, indicating a viable molecular target for therapy. In this study, we investigated novel non-peptide, cell-permeable small molecule, named LY5, medulloblastoma cells. LY5 inhibited...
Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) vivo. We asked whether TGF-β1 controls cell cycle status HSCs vitro to enhance reconstitution activity. To examine effect on HSC function, we used an culture system which single divide with retention their short- and long-term ability. Extensive single-cell analyses showed that, regardless its concentration, slowed down progression but consequently suppressed self-renewal...
Abstract Lung cancer is one of the most aggressive cancers with poor prognosis and high resistance rate. The family signal transducer activator transcriptions (STATs) appears to modulate in non-small cell lung (NSCLC). In this work, we demonstrated that STAT3/ZEB1 a critical axis gefitinib resistance. STAT3-targeted inhibition therefore new potential therapeutic strategy for cancer. Our small molecule screening identified relatively specific inhibitor, LL1. Pharmacological biochemical...
The two proteases, PLpro and Mpro, of SARS-CoV-2 are essential for replication the virus. Using a structure-based co-pharmacophore screening approach, we developed novel dual-targeted inhibitor that is equally potent in inhibiting Mpro SARS-CoV-2. contains warhead, which can form covalent bond with catalytic cysteine residue either enzyme. maximum rate inactivation comparable to most inhibitors reported viral proteases drugs currently clinical use. inhibition appears be very specific...
Unpredicted human organ level toxicity remains one of the major reasons for drug clinical failure. There is a critical need cost-efficient strategies in early stages development assessment. At present, artificial intelligence methods are popularly regarded as promising solution chemical toxicology. Thus, we provided comprehensive silico prediction models eight significant end points using machine learning, deep and transfer learning algorithms. In this work, our results showed that...
Targeting signal transducer and activator of transcription 3 (STAT3) is a potential anticancer strategy. However, STAT3 inhibitors with good selectivity bioavailability are rare. The aim this study was to discover selective direct druglikeness. By the advanced multiple ligand simultaneous docking (AMLSD) method, compound 9 designed as an orally bioavailable inhibitor that presented superior druggability compared other representative inhibitors. directly selectively inhibited pY705 site...
Abstract Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis. In this study, natural product cryptotanshinone was firstly remodeled and modified more effective inhibitor by structure-based strategy. The synthetic derivative KYZ3 had 22–24-fold increase in antitumor activity than on two TNBC cell lines but little effect normal epithelial MCF-10A cells. Further investigation showed that...
Signal Transducer and Activator of Transcription 3 (STAT3) is persistently activated in human liver colon cancer cells required for cell viability, survival migration. Therefore, inhibition STAT3 signaling may be a viable therapeutic approach these two cancers. We recently designed non-peptide small molecule inhibitor, LY5, using silico site-directed Fragment-based drug design (FBDD). The inhibitory effect on phosphorylation, migration colony forming ability by LY5 were examined cells....
Abstract Signal transducer and activator of transcription 3 (STAT3) is a well-known antitumor target. Exogenous ROS insult can lead to selective cytotoxicity against cancer cells. A combination STAT3 inhibition “oxidation therapy” may be new strategy address the multidrug-resistance issue due their important roles in survival drug resistance Here, series novel curcumin-BTP hybrids were designed evaluated as inhibitors with production activity. Compound 6b exerted best activity selectivity...