A5074353332- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Urinary Tract Infections Management
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Plant Pathogens and Fungal Diseases
- Phytochemical Studies and Bioactivities
- Biological Activity of Diterpenoids and Biflavonoids
- Cholinesterase and Neurodegenerative Diseases
- Traditional and Medicinal Uses of Annonaceae
- Carbohydrate Chemistry and Synthesis
- Molecular Biology Techniques and Applications
- Chemical synthesis and alkaloids
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Plant-Microbe Interactions and Immunity
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and Bioactive Compounds
- Histone Deacetylase Inhibitors Research
- Medicinal Plants and Bioactive Compounds
Chinese Academy of Sciences
2019-2025
Shanghai Institute of Materia Medica
2019-2025
Center for Life Sciences
2025
Peking University
2025
Beijing National Laboratory for Molecular Sciences
2025
Academy of Military Medical Sciences
2021-2024
Institute of Microbiology
2021-2024
Jiangnan University
2024
Beijing University of Chemical Technology
2023
Chinese PLA General Hospital
2023
An endophytic fungus, Gliocladium roseum (NRRL 50072), produced a series of volatile hydrocarbons and hydrocarbon derivatives on an oatmeal-based agar under microaerophilic conditions as analysed by solid-phase micro-extraction (SPME)-GC/MS. As example, this organism extensive the acetic acid esters straight-chained alkanes including those pentyl, hexyl, heptyl, octyl, sec-octyl decyl alcohols. Other were also organism, undecane, 2,6-dimethyl; decane, 3,3,5-trimethyl; cyclohexene, 4-methyl;...
Acetylcholinesterase (AChE, EC 3.1.1.7) inhibitors are the only registered drugs used to treat Alzheimer's disease (AD). New AChE may contribute design of new pharmaceuticals and supply information which will facilitate understanding interaction between enzyme. The dried root Salvia miltiorhiza is called 'Danshen' in China, has been for treatment cerebrovascular CNS deterioration old age over one thousand years. In this work, a modified Ellman method was guide fractionation active inhibitory...
Nowadays, simultaneous inhibition of multiple targets through drug combination is an important anticancer strategy owing to the complex mechanism behind tumorigenesis. Recent studies have demonstrated that histone deacetylases (HDACs) will lead compensated activation a notorious cancer-related target, signal transducer and activator transcription 3 (STAT3), in breast cancer cascade, which probably limits anti-proliferation effect HDAC inhibitors solid tumors. By incorporating pharmacophore...
Urinary tract infections (UTIs) are among the most common acquired bacterial in humans. The current gold standard method for identification of uropathogens clinical laboratories is cultivation. However, culture-based assays have substantial drawbacks, including long turnaround time and limited culturability many potential pathogens. Nanopore sequencing technology can overcome these limitations detect pathogens while also providing reliable predictions drug susceptibility samples. Here, we...
The early identification of pathogens and their antibiotic resistance are essential for the management treatment patients affected by ventilator-associated pneumonia (VAP). However, microbiological culture may be time-consuming has a limited culturability many potential pathogens. In this study, we developed rapid nanopore-based metagenomic next-generation sequencing (mNGS) diagnostic assay detection VAP antimicrobial genes (ARGs).Endotracheal aspirate (ETA) samples from 63 with suspected...
Abstract Background Early availability of pathogen identification in urinary tract infections (UTIs) has critical importance disease management. Metagenomic next-generation sequencing (mNGS) the potential to transform how acute and serious are diagnosed by offering unbiased culture-free detection. However, clinical experience with application mNGS test is relatively limited. Methods We therefore established a MinION-based pathogens diagnostic platform evaluated its for implementation UTIs...
Colletotrichum dematium is an endophytic fungus recovered from a Pteromischum sp. growing in tropical forest Costa Rica. This makes novel peptide antimycotic, colutellin A, with MIC of 3.6 μg ml−1 (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum. Collutellin A has mass 1127.7 Da contains residues Ile, Val, Ser, N-methyl-Val β-aminoisobutryic acid nominal molar ratios 3 : 2 1 1, respectively. Independent lines evidence suggest that the cyclic sequences Val-Ile-Ser-Ile Ile-Pro-Val...
Abstract Deep generative models have advanced drug discovery but often generate compounds with limited structural novelty, providing constrained inspiration for medicinal chemists. To address this, we develop TransPharmer, a model that integrates ligand-based interpretable pharmacophore fingerprints pre-training transformer (GPT)-based framework de novo molecule generation. TransPharmer excels in unconditioned distribution learning, generation, and scaffold elaboration under pharmacophoric...
Steroids have consistently drawn scientific attention due to their diverse structures and exceptional pharmacological activities. However, halogenated natural steroids remain relatively rare, especially for those derived from plants. In this study, two chlorinated C19 hocarnoids A (1) B (2) were identified the folk medicinal plant Hoya carnosa, representing first examples of C-16 steroids. Semisynthesis compounds 1 2 was completed in 4 5 linear steps with 28.2% 25.3% overall yields through a...
Nipah virus (NiV) is an emerging zoonotic pathogen whose surface glycoprotein (G)-mediated host cell invasion mechanism leads to fatal encephalitis in infected patients (case fatality rate 40–75%). Given the limitations of existing diagnostic technologies, such as low sensitivity and prolonged processing times, we prepared anti-NiV-G monoclonal antibody establish a novel Amplified Luminescent Proximity Homogeneous Assay (AlphaLISA) detection system. Firstly, five high-affinity antibodies...
The centipede Scolopendra subspinipes mutilans L. Koch ('Wugong'), the beetle Mylabris phalerata Pallas ('Ban mao') and earthworm Pheretima aspergillum Chen ('DiLong') have a reputation in traditional Chinese medicine for reducing symptoms of central nervous system decline, including memory loss. A series extracts all three organisms was tested acetylcholinesterase (AChE) inhibition copper ion binding effects, latter likely to reduce oxidative damage caused by excess copper. chloroform...
Metagenomic next-generation sequencing (mNGS) is a novel useful strategy that increasingly used for pathogens detection in clinic. Some emerging mNGS technologies with long-read ability are to decrease time and increase diagnosed accuracy, which of great significance rapid pathogen diagnosis. Reliable DNA extraction considered critical the success sequencing; hence, there thus an urgent need gentle method get unbiased more integrate from all kinds pathogens. In this study, we systematically...
Urceoloids A (1) and B (2), two C19 steroids with a rearranged new carbon skeleton by featuring very unique spiro[4.4]nona-3,6,8-triene system, biosynthetically related known steroid (3) were isolated from Urceola quintaretii. Their structures completely established combined method. plausible biosynthetic pathway for the represented compounds 1 2 was proposed. Compounds 3 showed immunosuppressive activities.
The genus Salix L. is traditionally used in folk medicine to alleviate pain caused by various kinds of inflammation. In the present study, 10 undescribed salicin derivatives along with 5 known congeners were isolated from barks tetrasperma, and their structures elucidated spectroscopic analyses, single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations, chemical conversions. Compounds 4–6 significantly inhibited NO production lipopolysaccharide (LPS)-induced RAW...
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