A5100661871- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Aquatic Ecosystems and Phytoplankton Dynamics
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
- Drug Transport and Resistance Mechanisms
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Animal Virus Infections Studies
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Methane Hydrates and Related Phenomena
- Microbial Community Ecology and Physiology
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Heavy metals in environment
- interferon and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Peptidase Inhibition and Analysis
Fujian Institute of Research on the Structure of Matter
2014-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2011-2025
Fudan University
2005-2025
Zhongshan Hospital
2015-2025
Peking University
2015-2025
Peking University Third Hospital
2024-2025
Huazhong Agricultural University
2002-2025
Henan Provincial People's Hospital
2025
Henan University
2020-2025
Abstract Although microRNAs (miRNA) have been broadly studied in cancer, comparatively less is understood about their role progression. Here we report that miR-153 has a dual during progression of colorectal cancer by enhancing cellular invasiveness and platinum-based chemotherapy resistance. miRNA profiling revealed was highly expressed model advanced stage cancer. Its upregulation also noted primary human compared with normal colonic epithelium more stages early disease. In patients...
Background: A therapeutic strategy involving combined treatment with lenvatinib plus pembrolizumab (LEP) has demonstrated a relatively high antitumor response in several solid tumors; however, the efficacy and safety of LEP patients refractory bile tract carcinoma (BTC) remains unknown. Methods: This is single-arm study for preliminary assessment tolerability who experienced progression from prior systemic treatments. Pre-treatment tumor tissues were collected to retrospectively evaluate...
Abstract Background PI3K/AKT is a vital signaling pathway in humans. Recently, several inhibitors were reported to have the ability reverse cancer multidrug resistance (MDR); however, specific targets pathways and mechanisms associated with MDR not been found because many of multiple within large candidate protein pool. AKT activation one presumed mechanism by which develops during treatment. Methods The effects inhibiting PI3K 110α 110β BAY-1082439 treatment CRISPR/Cas9 knockout examined...
The Hippo pathway plays a critical role in cell growth and tumorigenesis. activity of TEA domain transcription factor 4 (TEAD4) determines the output signaling; however, regulation function TEAD4 has not been explored extensively. Here, we identified glucocorticoids (GC) as novel activators TEAD4. GC treatment facilitated glucocorticoid receptor (GR)-dependent nuclear accumulation transcriptional activation positively correlated with GR expression human breast cancer, high predicted poor...
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown.Based on single gene knockout, we studied CDK6-PI3K axis ABCB1-mediated MDR in human cells. CRISPR/Cas9 technique was performed KB-C2 cells to knockout cdk6 or cdk4 gene. Western blot, RT-PCR and transcriptome analysis were investigate target deletion expression critical signaling factors. The effect...
Polyamines are a class of small polycationic alkylamines that play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated considered therapeutic target cancer. However, targeting polyamine as monotherapy often exhibits limited efficacy, the underlying mechanisms incompletely understood. Here we report activation catabolism promotes glutamine metabolism, leading to targetable vulnerability lung Genetic pharmacological spermidine/spermine...
Taste and smell disorders (TSDs) can induce diminished interest in food, inadequate nutrient intake, emotional irregularities, particularly among cancer patients. Previous research found that the main culprits of TSD development patients are cytotoxic drugs such as taxol, fluorouracil, cyclophosphamide, anthracycline-based drugs. The advent targeted vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) has significantly extended survival time patients, thus...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, necessitating approaches to improve prognosis. As the mediator of allergic process, mast cells have been found in various cancers and are associated with survival. However, biological behaviors tumor‐associated (TAMCs) remain unclear. Herein, an excessive infiltration TAMCs PDAC demonstrated, which apparently poor survival patients. recruit CXCR2 + MCs into TME, then inhibited ferroptosis, maintained their...
Highlights•The E-cadherin-GFP mouse allows in situ quantification of E-cadherin mobility•We monitored mobility during tissue homeostasis and disease development•Invasive pancreatic cancer driven by mutant Kras/p53 increases mobility•Dasatinib treatment reverts reinforces tumor cell junctionsSummaryE-cadherin-mediated cell-cell junctions play a prominent role maintaining the epithelial architecture. The disruption or deregulation these adhesions can lead to collapse epithelia that precedes...
The overexpression of ABC transporters induced by anticancer drugs has been found to be the main cause multidrug resistance. It is actually also a strategy which cancer cells escape being killed. Tetrandrine natural product extracted from stem Tinospora crispa. In this study, tetrandrine showed synergistic cytotoxic activity in combinational use with chemotherapeutic drugs, such as Doxorubicin, Vincristine, and Paclitaxel, both drug-induced MDR1 gene-transfected that over-expressed...
Urinary tract infections (UTIs) are among the most common acquired bacterial in humans. The current gold standard method for identification of uropathogens clinical laboratories is cultivation. However, culture-based assays have substantial drawbacks, including long turnaround time and limited culturability many potential pathogens. Nanopore sequencing technology can overcome these limitations detect pathogens while also providing reliable predictions drug susceptibility samples. Here, we...
With a worldwide prevalence of ~5%, attention deficit hyperactivity disorder (ADHD) has become one the most common psychiatric disorders. The polygenetic nature ADHD indicates that multiple genes jointly contribute to development this complex disease. Studies aiming explore genetic susceptibility have been increasing in recent years. There is growing need integrate data from various studies provide comprehensive set and uniform access for convenience in-depth mining. So far, there no such...
Genome-wide association study (GWAS) is widely utilized to identify genes involved in human complex disease or some other trait. One key challenge for GWAS data interpretation causal SNPs and provide profound evidence on how they affect the Currently, researches are focusing identification of candidate variants from most significant GWAS, while there lack support biological mechanisms as represented by pathways. Although pathway-based analysis (PBA) has been designed disease-related pathways...
To demonstrate the responses of plant (Pakchoi) and soil to poly-γ-glutamic acid (γ-PGA) is essential better understand pathways promotional effect γ-PGA on growth. In this study, effects nutrient availability, uptake ability, metabolism its distribution in a plant-soil system were tested using labeled synthesized from 13C1-15N-L-glutamic (L-Glu). significantly improved nitrogen (N), phosphorus (P), potassium (K) hence increased biomass. greatly strengthened capacity through enhancing both...
Taxus species are well-known for paclitaxel, which exhibits antitumor activities and is used treating various cancers. Although most widespread in many areas, few studies have characterized the variation metabolism among different species. Using an integrated approach involving 'tandem mass tag' labeling liquid chromatography–tandem spectrometry (HPLC–MS), proteomes of T. media mairei were investigated 4078 proteins quantified. Screening classification differentially expressed revealed...
Phage-derived lysins can hydrolyse bacterial cell walls and show great potential for combating Gram-positive pathogens. In this study, the of LysEF-P10, a new lysin derived from isolated Enterococcus faecalis phage EF-P10, as an alternative treatment multidrug-resistant E. infections, was studied. LysEF-P10 shares only 61% amino acid identity with its closest homologues. Four proteins were expressed: cysteine, histidine-dependent amidohydrolase/peptidase (CHAP) domain (LysEF-P10C), putative...
Abstract Increased glycolysis is a hallmark of tumor, which can provide tumor cells with energy and building blocks to promote cell proliferation. Recent studies have shown that not only the expression glycolytic genes but also their subcellular localization undergoes variety changes development different types tumors. In this study, we performed comprehensive analysis gluconeogenesis based on data from TCGA identify those significant tumor-promoting potential across 14 This confirms are...
Abstract Background Immunocheckpoint inhibitor(ICI) is a major breakthrough in tumor treatment. It can activate the patient’s own immune system and play an anti-tumor role, but not all patients benefit from it. At present, there still lack of effective biomarkers to guide clinical application. The systemic inflammation(SII) index reflects inflammatory state patients. Prognostic nutrition index(PNI) be used evaluate status Therefore, SII PNI indexes may have some value predicting efficacy...