A5059648987- Advanced Differential Geometry Research
- Polyamine Metabolism and Applications
- Epigenetics and DNA Methylation
- Nasolacrimal Duct Obstruction Treatments
- Amino Acid Enzymes and Metabolism
- Ophthalmology and Eye Disorders
Fudan University
2024-2025
Eye & ENT Hospital of Fudan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Polyamines are a class of small polycationic alkylamines that play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated considered therapeutic target cancer. However, targeting polyamine as monotherapy often exhibits limited efficacy, the underlying mechanisms incompletely understood. Here we report activation catabolism promotes glutamine metabolism, leading to targetable vulnerability lung Genetic pharmacological spermidine/spermine...
Objectives Transforming growth factor β1 (TGFβ1)-interleukin 11 (IL11) is a newly found critical signaling pathway in fibrotic diseases such as Graves’ orbitopathy (GO). It has now been confirmed that enhanced glycolysis plays key role the pathogenesis of GO. However, little known about relationship between and IL11-mediated fibrosis This study aimed to identify TGFβ1-IL11 investigate IL11 glycolysis-facilitated Methods Orbital connective tissues were collected from GO control patients....
Introduction Tocilizumab (TCZ) has been demonstrated to be effective in treating thyroid-associated ophthalmopathy (TAO); however, its efficacy hormone-resistant dysthyroid optic neuropathy (DON) remains unclear. This study aims identify baseline and post-treatment indicators that can predict the necessity for surgical intervention following TCZ therapy. Methods Thirty-one DON patients treated with were categorized into surgery (n=15, 7 males, 8 females) non-surgery (n=16, groups based on...