A5003164912- Ocular Oncology and Treatments
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Cancer-related Molecular Pathways
- Ophthalmology and Eye Disorders
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Head and Neck Cancer Studies
- Retinopathy of Prematurity Studies
- Nonmelanoma Skin Cancer Studies
- interferon and immune responses
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cell Adhesion Molecules Research
- IgG4-Related and Inflammatory Diseases
- Neonatal Health and Biochemistry
- Nasolacrimal Duct Obstruction Treatments
- Corneal surgery and disorders
- Reconstructive Facial Surgery Techniques
- Retinal and Optic Conditions
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Fudan University
2015-2025
Eye & ENT Hospital of Fudan University
2016-2025
West China Hospital of Sichuan University
2024-2025
Sichuan University
2024-2025
Ningxia Medical University
2024-2025
Chinese People's Liberation Army
2023
Shanghai Medical College of Fudan University
2022
Nanchang University
2018-2021
Jiangxi Provincial Children's Hospital
2020-2021
Uveal melanoma (UM) is an aggressive intraocular malignancy derived from melanocytes in the uvea tract of eye. Up to 50% patients with UM develop distant metastases which usually fatal within one year; preventing therefore essential. Metabolic reprogramming plays a critical role progression and metastasis. However, metabolic phenotype cells hypoxic tumor not well understood. Here, we report that hypoxia-induced BNIP3 reprograms cell metabolism, promoting their survival In response hypoxia,...
Purpose.: To evaluate the effects of intravitreal injection liposomes encapsulating tacrolimus (FK506) on experimental autoimmune uveoretinitis (EAU) in Lewis rats. Methods.: Liposomes containing were prepared by reverse-phase evaporation vesicles. EAU was induced rats subcutaneous interphotoreceptor retinoid-binding protein R16 peptide emulsified adjuvant. Ten days later, intravitreally injected with saline, tacrolimus, tacrolimus-loaded liposomes, or unloaded liposomes. Clinical signs...
To evaluate the efficacy, complications, and clinical characteristics, including ocular toxicity, of intravitreal melphalan(IVM) treatment for vitreous seeding in Chinese retinoblastoma patients.This was a retrospective, non-comparative analysis 30 consecutive eyes 23 patients with viable persistent or recurrent following treatment. All received IVM injections (20-33 μg). Vitreous control, determination characteristics melphalan treatments were observed.The mean patient age at time injection...
Protease-activated receptor-2 (PAR-2)-modulated tight junctions (TJs) have been suggested to be involved in the pathogenesis of chronic inflammatory diseases. However, immunopathogenesis remains investigated among patients with allergic rhinitis (AR).This study sought investigate role PAR-2 modulation epithelial barrier function and expression TJs nasal mucosa AR patients.The control subjects by immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), western...
Purpuse: To determine whether treatment with anti-IL-17 antibody could suppress the intraocular inflammation of experimental autoimmune uveoretinitis (EAU) in rats. Methods: Rats were immunized interphotoreceptor retinoid binding protein (IRBP) R16 peptide and treated antibody. Clinical signs ocular histological sections observed graded. Cytokine levels supernatants cells from draining lymph nodes measured by enzyme-linked immunosorbent assay (ELISA). Delayed-type hypersensitivity (DTH)...
Retinoblastoma protein (Rb) is a prototypical tumor suppressor that vital to the negative regulation of cell cycle and progression. Hypo-phosphorylated Rb associated with G0/G1 arrest by suppressing E2F transcription factor activity, whereas hyper-phosphorylation allows release progression from S phase. However, factors regulate cyclin-dependent kinase (CDK)-dependent during remain obscure. In this study, we show throughout cycle, specifically small ubiquitin-like modifier (SUMO)ylated at...
We identified the timing of natural involution acute retinopathy prematurity (ROP) not requiring treatment and determined risk factors associated with delayed involution.In this retrospective case series, 82 eyes (the more severe eye) infants who developed at least one clock hour ROP, stages 1 through 3, but didn't progress to type were selected for analysis. The location, extent, severity ROP documented by investigators during serial retinal examinations. onset completion ROP's from a...
To investigate the association between myopic severity and retinal microvascular density, choroidal vascularity retrobulbar blood flow in adult anisomyopes.This study comprised 90 eyes of 45 anisomyopes who were recruited for Colour Doppler imaging (CDI) optical coherence tomography angiography (OCTA). The superficial vessel density (SVD), deep (DVD), thickness (ChT) vascularity, including total area (TCA), luminal (LA), stromal (SA) Choroidal Vascularity Index (CVI), measured using OCTA....
Scleral extracellular matrix (ECM) remodeling is thought to play a critical role in the pathogenesis of glaucoma. Mechanical strain induced by elevated intraocular pressure can promote myofibroblast differentiation fibroblasts and result scleral ECM remodeling; however, underlying mechanism remains poorly understood. Yes-associated protein (YAP) mechanosensory key downstream transcriptional effector Hippo signaling pathway. Here, we investigated YAP mechanical strain-induced transformation...
Importance Adjuvant therapy is an important and effective treatment for retinoblastoma. However, there a lack of head-to-head clinical trials comparing 3 vs 6 cycles CEV chemotherapy (carboplatin, etoposide, vincristine) enucleated unilateral retinoblastoma with high-risk pathological features. Objective To assess whether noninferior to Design, Setting, Participants This double-center, randomized, open-label, noninferiority trial was conducted at 2 premier eye centers in China included 187...
Objectives Transforming growth factor β1 (TGFβ1)-interleukin 11 (IL11) is a newly found critical signaling pathway in fibrotic diseases such as Graves’ orbitopathy (GO). It has now been confirmed that enhanced glycolysis plays key role the pathogenesis of GO. However, little known about relationship between and IL11-mediated fibrosis This study aimed to identify TGFβ1-IL11 investigate IL11 glycolysis-facilitated Methods Orbital connective tissues were collected from GO control patients....
Purpose: To explore the characteristics of retinal, choroidal, and retrobulbar blood flows in myopic patients with posterior staphyloma (PS) using ultra-widefield optical coherence tomography angiography (UWF-OCTA) Color Doppler imaging (CDI). Methods: The retrospective cross-sectional study enrolled 134 adults high myopia from Eye ENT Hospital Fudan University December 2021 to September 2022. After propensity score matching, 45 eyes 30 32 were included PS non-PS (NPS) groups, respectively....
Purpose: To explore the levels of cytokines in aqueous humor (AH) patients diagnosed with retinoblastoma (RB) who received intravitreal melphalan (IVM). Methods: A total 28 eyes from 27 RB IVM were enrolled, along 14 congenital cataracts as controls. The clinical features recorded before and after IVM. concentrations AH samples collected these measured by a suspension array system. Results: IL-8, IL-17A, Eotaxin, G-CSF, PDGF-BB increased significantly following administration (p<0.05)....
Introduction Tocilizumab (TCZ) has been demonstrated to be effective in treating thyroid-associated ophthalmopathy (TAO); however, its efficacy hormone-resistant dysthyroid optic neuropathy (DON) remains unclear. This study aims identify baseline and post-treatment indicators that can predict the necessity for surgical intervention following TCZ therapy. Methods Thirty-one DON patients treated with were categorized into surgery (n=15, 7 males, 8 females) non-surgery (n=16, groups based on...
Abstract Background Clinical trials have shown that anti-PD1 therapy, either as a monotherapy or in combination, is effective and well-tolerated patients with recurrent unresectable hepatocellular carcinoma (HCC). In this study, we aimed to investigate the prognostic value of immune-nutritional biomarkers measuring effects therapy these patients. Methods We enrolled followed up 85 diagnosed advanced HCC who underwent at First Medical Centre Chinese People’s Liberation Army (PLA) General...
Abstract Background To present the characteristics and treatment outcome of patients with intraocular retinoblastoma in a Chinese cooperative group. Procedure Between January 2005 March 2009, 159 eyes 133 were included this retrospective study. The International Classification Retinoblastoma (ICRB) staging system was noted for each patient. Cases visible extraocular extension at diagnosis excluded. patient data reviewed demographic information, clinical findings, managements. Results Of...
Introduction: Chronic rhinosinusitis (CRS) is often classified primarily on the basis of absence or presence nasal polyps (NPs), that is, as CRS with (CRSwNP) without (CRSsNP). Additionally, according to percentage eosinophils, CRSwNP can be further divided into eosinophilic (ECRSwNP) and non-ECRSwNP. a significant public health problem considerable socioeconomic burden. Previous research reported pathophysiology complex, multifactorial disease. There have been many studies its etiology, but...
Purpose . To describe the clinical manifestations and treatment outcomes of syphilitic uveitis in a Chinese population. Methods This is retrospective case series 15 consecutive patients with treated at referral center between 2012 2015. Results Fifteen were diagnosed based on positive serological tests. Nine male. Coinfection human immunodeficiency virus was detected two patients. Twenty eyes presented panuveitis all had posterior involvement. The most frequent retinal vasculitis papillitis,...
This study aimed to evaluate the effects of retinal artery occlusions caused by cosmetic facial filler injections on retrobulbar blood flow parameters.This was a retrospective, noncomparative case series. Ten consecutive patients with fundus were evaluated using color Doppler imaging (CDFI). The peak systolic velocity and end diastolic ophthalmic artery, central posterior ciliary arteries determined. clinical features, including material, injection site, best-corrected visual acuity,...
<h3>Purpose</h3> To evaluate the effects of intra-arterial chemotherapy on retrobulbar blood flow parameters in patients with retinoblastoma. <h3>Methods</h3> 20 eyes 10 unilateral retinoblastoma that were treated evaluated using colour Doppler imaging. The peak systolic and end-diastolic velocities ophthalmic, central retinal posterior ciliary arteries determined. pulsatility resistance indices calculated automatically. eye was compared untreated (control) itself before after chemotherapy....