A5087958935- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Complementary and Alternative Medicine Studies
- Autoimmune Bullous Skin Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune cells in cancer
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Asthma and respiratory diseases
- Clinical practice guidelines implementation
- Retinoids in leukemia and cellular processes
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Bioactive Compounds
- Aquaculture Nutrition and Growth
- Gut microbiota and health
- Agricultural and Environmental Management
- Phytochemistry Medicinal Plant Applications
- Bioinformatics and Genomic Networks
Guangzhou University of Chinese Medicine
2016-2025
Wuhan University
2025
Jinggangshan University
2025
Shantou University
2024
University Medical Center Utrecht
2021-2023
Utrecht University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Women's Hospital, School of Medicine, Zhejiang University
2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2014-2022
Boston University
2022
Serum and plasma contain abundant biological information that reflect the body's physiological pathological conditions are therefore a valuable sample type for disease biomarkers. However, comprehensive profiling of serological proteome is challenging due to wide range protein concentrations in serum. Methods: To address this challenge, we developed novel in-depth serum proteomics platform capable analyzing across ~10 orders or magnitude by combining data obtained from Data Independent...
Summary Psoriasis is an immune-mediated inflammatory skin disease that mainly affects the barrier. Treatment for psoriasis includes conventional immunosuppressive drugs. However, long-term treatment with global agents may cause a variety of side effects, including nephrotoxicity and infections. Kaempferol, natural flavonol present in various plants, known to possess potent anti-inflammatory, anti-oxidant anti-cancerous properties. it unknown whether kaempferol also anti-psoriatic. Here we...
The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify AMER1 as a key regulator of ferroptosis. loss causes resistance to in colorectal (CRC) cells. Interestingly, AMER1-deficient CRC cells preferentially form distant metastases, while AMER1-naive mainly invade lymph nodes. Moreover, the inhibitor liproxstatin-1 effectively promotes hematogenous transfer Mechanistically, binds SLC7A11 ferritin light chain (FTL) recruits β-TrCP1/2, which degrade FTL by...
Immunometabolism in the tumor microenvironment (TME) and its influence on immunotherapy response remain uncertain colorectal cancer (CRC). We perform immunometabolism subtyping (IMS) CRC patients training validation cohorts. Three IMS subtypes of CRC, namely, C1, C2, C3, are identified with distinct immune phenotypes metabolic properties. The C3 subtype exhibits poorest prognosis both cohort in-house cohort. single-cell transcriptome reveals that a S100A9+ macrophage population contributes...
BackgroundPsoriasis is an immune-mediated inflammatory skin disease. Psoriasis severity evaluation important for clinicians in the assessment of disease and subsequent clinical decision making. However, no objective biomarker available accurately evaluating psoriasis.ObjectiveTo define compare biomarkers progression psoriatic skin.MethodsWe performed proteome profiling to study proteins circulating serum from patients with psoriasis, arthritis ankylosing spondylitis, transcriptome sequencing...
Blue carbon ecosystems such as mangroves are natural barriers to resisting and alleviating the impact of storm surges extreme catastrophic weather. Accurate efficient determination aboveground biomass is great importance for protection restoration blue their response climate change. This study proposes a light gradient boosting model (LGBM) based on particle swarm optimization (PSO) algorithm feature selection. We constructed verified proposed using 227 quadrat datasets from field survey...
Introduction: Psoriasis is an inflammatory autoimmune skin disease that hard to cure and prone relapse. Currently available global immunosuppressive agents for psoriasis may cause severe side effects, thus it crucial identify new therapeutic reagents druggable signaling pathways psoriasis. Methods: To check the effects of SOCE inhibitors on psoriasis, we used animal models, biochemical approaches, together with various imaging techniques, including calcium, confocal FRET imaging. Results...
Introduction Portulaca oleracea L. (purslane) is a highly nutritious and edible wild vegetable beneficial to human health. However, its impacts on the structure of gut microbiota fecal metabolites in aging individuals remain unclear. This study aims clarify potential mechanisms aging-related Methods Naturally aged rats (18 months) were divided into two groups. One group was fed maintenance chow, other mixture with 3.5% purslane for 15 weeks. Hematoxylin-eosin staining, gas...
Introduction Psoriasis vulgaris (PV) is an inflammatory, chronically relapsing dermatological disease associated with significant comorbidities. Ixekizumab recommended as the first-line therapy for severe PV, but encounters persistent challenges relapse after treatment discontinuation. In clinical practice, Chinese herbal medicine (CHM) including Guben Qushi Huayu formula (GQHF) has been demonstrated effective in reducing PV relapse. However, there remains a scarcity of high-level...
The beneficial effect of quercetin in rheumatic diseases is unclear. Studies have already confirmed that human umbilical cord mesenchymal stem cells (hUCMSCs) alleviate some symptoms rheumatoid arthritis (RA) by their immunosuppressive capacities. This study explored whether there are additive effects and hUCMSCs on peripheral blood mononuclear (PBMCs) under simulated conditions. were pretreated with (10 μM) before coculture TNF-α/IFN-γ-stimulated PBMCs at a ratio 1:1 for 3 days. PBMC...
To provide evidence that the Chinese herbal medicine (CHM) PSORI-CM01 combined with Western reduces relapse rate of psoriasis vulgaris (PV), we plan to conduct a large-scale randomized control trial (RCT). In order improve and perfect RCT, this pilot study was designed determine feasibility potential modified protocol for full-scale RCT. Eligible patients (PV) were enrolled into comparison in which all subjects received topical sequential therapy or placebo 12 weeks. The primary outcome...
Psoriasis is an immune-mediated inflammatory skin disease that causes significant physical and psychological burden to the patient. While there currently no curative treatment, recent breakthroughs involving stem cell therapy, in particular, adipose tissue-derived from mesenchymal cells (AD-MSCs), have been promising. This single-arm study evaluated feasibility, safety, efficacy of AD-MSC infusions for treatment moderate severe psoriasis.A single-center, open-label pilot was conducted seven...
The precise pathogenesis of psoriasis remains incompletely explored. We aimed to better understand the underlying mechanisms psoriasis, using a systems biology approach based on transcriptomics and microbiome profiling.We collected skin tissue biopsies swabs in both lesional non-lesional 13 patients with 15 psoriatic arthritis healthy from 12 ankylosing spondylitis. To study similarities differences molecular profiles between these three conditions, associations host defence microbiota...
Psoriasis is a chronic skin disease, and topical sequential therapy with combination of calcipotriol betamethasone currently approved treatment. However, the exact mechanism by which this treatment regimen relieves psoriasis unknown.We assembled cohort 65 patients divided post-treatment into responder group non-responder according to Area Severity Index (PASI) score after 12-week We measured expression levels proteins in collected 130 serum samples using our in-depth proteomics platform...
Introduction Psoriasis vulgaris is a common skin disease that characterised by persistent localised erythematous scaly plaques. Yinxieling Chinese herbal formula for psoriasis has been used more than 20 years in China. To facilitate application, PSORI-CM01 was developed based on the optimisation and simplification of tablets performed previous study clinical practice. However, scientific evidence regarding whether effective original remains insufficient. Therefore, we designed randomised...
Metabolic status and gut microecology are implicated in psoriasis. Methotrexate (MTX) is usually the first-line treatment for this disease. However, relationship between MTX host metabolic microbiota unclear. This study aimed to characterize features of blood metabolome microbiome patients with psoriasis after MTX. Serum stool samples were collected from 15 Untargeted liquid chromatography–mass spectrometry metagenomics sequencing applied profile microbiome, respectively. We found that...