A5028859439- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Flavonoids in Medical Research
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- DNA Repair Mechanisms
- ATP Synthase and ATPases Research
- Forensic Entomology and Diptera Studies
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Neurological Disorders and Treatments
- Electron Spin Resonance Studies
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Epigenetics and DNA Methylation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cervical Cancer and HPV Research
- Immune Response and Inflammation
- Diabetes and associated disorders
- Neuroinflammation and Neurodegeneration Mechanisms
Qiqihar Medical University
2019-2024
Sichuan University
2009-2021
State Key Laboratory of Biotherapy
2009-2012
West China Hospital of Sichuan University
2009-2011
Shanghai Institute of Applied Physics
2010
Chinese Academy of Sciences
2010
Shanghai Medical College of Fudan University
2005
Ischemic stroke is a brain dysfunction disease caused by vascular obstruction. The expression of many kinds microRNAs (miRNAs) related to ischemic stroke. MiRNA has the ability reduce or save injury. Therefore, we aimed explore protective miRNA in ischemia-reperfusion process.The Gene Expression Omnibus (GEO) peripheral RNA sequencing (RNA-seq) datasets patients were analyzed search for differentially expressed miRNAs process. level 60 with and 23 age-matched healthy control inpatients was...
The aim of this study was to investigate the relationship between expression activating transcription factor 5 (ATF5) and clinicopathological features in human rectal cancer. Relative quantitative real-time RT-PCR immunohistochemical staining were used detect ATF5 mRNA protein 92 paired samples cancer distant normal tissues. Immunohistochemical matched tissue revealed that positive rate significantly higher compared tissue. Furthermore, poorly differentiated cancers well moderately...
The peroxisome proliferator-activated receptor-α (PPAR-α) has attracted considerable attention for its anti-inflammatory properties; however, Toll-like receptor (TLR) pathways have an essential proinflammatory role in acute pancreatitis (AP). This study aimed to evaluate the attenuation of inflammation by PPAR-α and investigate interaction between TLR AP.Acute was induced rats administration cerulein. agonist WY14643 and/or antagonist MK886 administered. severity AP determined measuring...
Doxorubicin (DOX) stimulates the generation of reactive oxygen species, thereby impairing mitochondrial functions. Angiotensin‑converting enzyme inhibitors (ACEIs) have been identified to exhibit protective effects on cardiovascular diseases. The present study aimed test hypothesis that an ACEI benazepril hydrochloride (HCl) may protect against DOX‑induced cardiotoxicity. DOX injury model was established using rat embryonic cardiac myoblast cells (H9c2 cell line) treated with <em>in...
Stroke is a disease with the highest incidence rate and mortality in world. The study aims to verify neuroprotective effect of Butylphthalide. mice were divided into sham group, MCAO + Butylphthalide-treated group. group administered 70 mg/kg Butylphthalide injection intraperitoneally after cerebral ischemia-reperfusion. normal saline same volume was for levels miR-21 brain tissue cells detected by qPCR. OGD/R injury model Neuro2A used simulate hypoxic-ischemic environment neurons vitro....
Glioma (GM) is one of the major global health problems across world. Circular RNAs (circRNAs) have been increasingly identified and characterized in almost every aspect biology, especially cancer biology. This study desires to investigate mechanism circ-PITX1 on regulating GM development. Quantitative reverse-transcription polymerase chain reaction was carried out measure expression circ-PITX1, which upregulated matched cancerous tissues adjacent noncancerous from 52 patients four cell lines...
Hepatocellular carcinoma (HCC) is characterized by a poor prognosis because of its insensitivity to radiation and chemotherapy. Recently, circular RNAs (circRNAs) have been found serve important roles in hepatocellular carcinogenesis. circ‑CCT3, novel circRNA, was screened from the differential tissue expression results circRNA microarray. Relative levels circ‑CCT3 specimens cell lines were evaluated reverse transcription‑quantitative PCR relationship between analyzed Kaplan‑Meier curves....
<title>Abstract</title> <bold>Background: </bold>Cerebral ischemia-reperfusion injury (CIRI) is a common pathological process in stroke, associated with neuronal cell death and neurological dysfunction. Metformin, widely used antidiabetic drug, has been found to possess various neuroprotective effects. However, its protective role CIRI the underlying mechanisms remain unclear. <bold>Objective: </bold>The present study aimed investigate effects of metformin on potential by which it may...
Objective To investigate the expression of caspase-8 and-10 in colorectal cancer and its association with tumor cell apoptosis.Methods The mRNA levels Caspase-8 were quantified by real-time polymerase chain reaction 121 cases coloreetal tissues,121 normal adjacent tissues as well 52 eoloreetal adenomas.Apoptotie cells detected situ terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL)method.Results Wast up-regulated,and Caspase-10 down-regulated adenomas compared...
Objective To elucidate the miR-155 and miR-200c expression in rectal callcers,and analyze correlation of their with clinicopathological features.Methods Real-time PCR was used to quantify 71 pairs cancer normal mucosa samples,and relationship features analyzed.Results The cancers up-regulated compared (P 0.05).Condusion overexpression may play acertain roleinthe development cancer.MiR-200c represent a potential indicator auxiliary diagnosis,therapeutic effect prognosis cancer. Key words:...