A5048394953- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Plant responses to elevated CO2
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Pharmaceutical and Antibiotic Environmental Impacts
- RNA Research and Splicing
- Pesticide and Herbicide Environmental Studies
- Plant Reproductive Biology
- Perovskite Materials and Applications
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Kruppel-like factors research
- Luminescence Properties of Advanced Materials
- Immunotherapy and Immune Responses
- Environmental Toxicology and Ecotoxicology
- Hippo pathway signaling and YAP/TAZ
- Plant Gene Expression Analysis
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Gene Regulatory Network Analysis
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
Xinjiang Medical University
2025
Jiangsu Normal University
2022-2024
Shanghai Jiao Tong University
2009-2024
Erasmus MC
2024
Nantong University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Second Affiliated Hospital of Nanjing Medical University
2019-2024
Affiliated Hospital of Guizhou Medical University
2023
GlaxoSmithKline (United States)
2018-2023
Network inference algorithms are powerful computational tools for identifying putative causal interactions among variables from observational data. Bayesian network hold particular promise in that they can capture linear, non-linear, combinatorial, stochastic and other types of relationships across multiple levels biological organization. However, challenges remain when applying these to limited quantities experimental data collected systems. Here, we use a simulation approach make advances...
Background At present, plant molecular systematics and DNA barcoding techniques rely heavily on the use of chloroplast gene sequences. Because relatively low evolutionary rates genes, there are very few choices suitable for studies angiosperms at taxonomic levels, species. Methodology/Principal Findings We scanned entire genomes 12 genera to search highly variable regions. The sequence data 9 were from GenBank 3 our own. identified nearly 5% most loci all in each genus, then selected 23 that...
The mammalian kidney is organized into a cortex where primary filtration occurs, and medullary region composed of elongated tubular epithelia urine concentrated. We show that the cortico-medullary axis organization function regulated by Wnt7b signaling. future collecting duct network specifically expresses Wnt7b. In absence Wnt7b, cortical epithelial development normal but zone fails to form be concentrated normally. analysis cell division planes in epithelium emerging indicates bias along...
Abstract The chloroplast maturase K gene ( matK ) is one of the most variable coding genes angiosperms and has been suggested to be a “barcode” for land plants. However, exhibits low amplification sequencing rates due universality currently available primers mononucleotide repeats. To resolve these technical problems, we evaluated entire region find 600–800 bp that highly variable, represents best all regions with priming sites conservative enough design universal primers, avoids After...
Brassinosteroids (BRs) are known to protect crops from the toxicity of herbicides, fungicides and insecticides. It is shown here that application 24-epibrassinolide (EBR) accelerated metabolism various pesticides consequently reduced their residual levels in cucumber ( Cucumis sativus L). Chlorpyrifos, a widely used insecticide, caused significant reductions net photosynthetic rate (Pn) quantum yield PSII (Phi(PSII)) leaves. EBR pretreatment alleviated declines Pn Phi(PSII) by chlorpyrifos...
The administration of cisplatin is limited due to its nephrotoxic side effects, and prevention this nephrotoxicity difficult. Mesenchymal stem cell (MSC)-derived exosomes have been implicated as a novel therapeutic approach for tissue injury. In study, we demonstrated that the pretreatment human umbilical cord MSC-derived (hucMSC-Ex) can prevent development cisplatin-induced renal toxicity by activation autophagy in vitro vivo. vitro, rat tubular epithelial (NRK-52E) cells were pre-incubated...
Abstract Cystathionine β-synthase (CBS) is responsible for the first enzymatic reaction in transsulfuration pathway of sulfur amino acids. The molecular function and mechanism CBS as well that remain ill-defined cell proliferation death. In present study, we designed, synthesized obtained a bioactive inhibitor CH004 human CBS, which functions vitro vivo. inhibits activity, elevated cellular homocysteine suppressed production hydrogen sulfide dose-dependent manner cells or Chemical genetic...
Abstract SARS‐CoV‐2 attaches to its host receptor, angiotensin‐converting enzyme 2 (ACE2), via the receptor‐binding domain (RBD) of spike protein. The RBD glycoprotein is a critical target for development neutralizing antibodies and vaccines against SARS‐CoV‐2. However, high heterogeneity glycoforms may lead an incomplete neutralization effect impact immunogenic integrity RBD‐based vaccines. Investigating role different carbohydrate domains paramount importance. Unfortunately, there no...
High-temperature scintillation detectors play a significant role in oil exploration. However, traditional scintillators have limited ability to meet the requirements of practical applications owing their low thermal stability. In this study, we designed and developed one-dimensional (1D) Cs5Cu3Cl6I2 scintillator with high addition, by preparing Cs5Cu3Cl7I, proved that exhibits stability because bridges linking structural units 1D chain structure are only formed I– ions, which improve...
Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding animals perceive their environments, learn, and behave. Attempts to reveal such neural flow have been made using linear computational methods, but interactions are known be nonlinear. Here, we demonstrate that dynamic Bayesian network (DBN) inference algorithm originally developed infer nonlinear transcriptional regulatory networks from gene expression data collected with...
ABSTRACT The effects of chilling under low light (9/7 °C, 100 µ mol m −2 s −1 ) on the photosynthetic and antioxidant capacities subsequent recovery were examined in two (one tolerant one sensitive) cucumber genotypes. Chilling resulted an irreversible inhibition net CO 2 assimilation growth for sensitive genotype, which was accompanied by decreases maximum velocity RuBP carboxylation Rubisco ( V cmax ), capacity ribulose‐1,5‐bisphosphate regeneration J max content activity, quantum...
Abstract The chloroplast thioredoxins (TRXs) function as messengers of redox signals from ferredoxin to target enzymes. In this work, we studied the regulatory impact pea (Pisum sativum) TRX-F on magnesium (Mg) chelatase CHLI subunit and enzymatic activation Mg in vitro vivo. vitro, reduced activated ATPase activity enhanced reconstituted three recombinant subunits CHLI, CHLD, CHLH combination with regulator protein GENOMES UNCOUPLED4 (GUN4). Yeast two-hybrid bimolecular fluorescence...
Abstract Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that Hippo–YAP signalling, a key pathway regulates cell proliferation and organ size, under control switch. We show TEAD4, transcription factor mediates undergoes alternative facilitated by tumour suppressor RBM4, producing truncated isoform, TEAD4-S, which lacks an N-terminal DNA-binding domain, but maintains YAP interaction domain. TEAD4-S...
High-resolution X-ray imaging is increasingly required for medical diagnosis and large-area detection. However, the issues of scattering optical crosstalk are limiting spatial resolution indirect imaging. In this study, a feasible efficient strategy proposed to in situ synthesize flexible Cs3 Cu2 I5 :2%In+ @paper as superior scintillator film, which can be scaled up an ultra-large area 4800 cm2 . The as-obtained performs fascinating photoluminescence quantum efficiency 88.14%, steady state...
Despite extensive research, the origin and evolution of chloroplast division machinery remain unclear. Here, we employ recently sequenced genomes transcriptomes Archaeplastida clades to identify core components reconstruct their evolutionary histories, respectively. Our findings show that complete ring structures emerged in Charophytes. We find Glaucophytes experienced strong selection pressure, generating diverse variants adapted changing terrestrial environments. By integrating functions...