A5056363668- DNA Repair Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Enzyme Production and Characterization
- DNA and Nucleic Acid Chemistry
- Immune Response and Inflammation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Algal biology and biofuel production
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- HIV/AIDS drug development and treatment
- RNA and protein synthesis mechanisms
- Bioactive natural compounds
- Animal Virus Infections Studies
- Enzyme Structure and Function
- Genomics and Chromatin Dynamics
- Microbial Metabolites in Food Biotechnology
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- Animal Disease Management and Epidemiology
- RNA Research and Splicing
Nantong University
2025
Zhejiang Chinese Medical University
2020-2025
National University of Defense Technology
2025
Tianjin Medical University Cancer Institute and Hospital
2025
Anhui Medical University
2025
University of Chinese Academy of Sciences
2021-2023
Zhujiang Hospital
2020-2021
Southern Medical University
2020-2021
Fred and Pamela Buffett Cancer Center
2015-2017
Susan Thompson Buffett Foundation
2017
Natural tetracyclic diterpenoid aphidicolin is a potent and specific inhibitor of B-family DNA polymerases, haltering replication possessing strong antimitotic activity in human cancer cell lines. Clinical trials revealed limitations as an antitumor drug because its low solubility fast clearance from plasma. The absence structural information hampered the improvement aphidicolin-like inhibitors: more than 50 modifications have been generated so far, but all lost inhibitory properties. Here...
DNA replication in almost all organisms depends on the activity of primase, a DNA-dependent RNA polymerase that synthesizes short primers defined size for polymerases. Eukaryotic and archaeal primases are heterodimers consisting small catalytic large accessory subunits, both which necessary activity. The mode interaction primase subunits with substrates during various steps primer synthesis results counting length is not clear. Here we show C-terminal domain subunit (p58C) plays major role...
Background: Few studies focused on the effects of sarcopenia lung cancer in general population and optimizing nutritional intake may be a feasible way to manage sarcopenia. We sought systematically investigate associations symptoms with incidence mortality population, whether dietary patterns could modify these risks. Methods: A total 361 763 participants (mean age: 56.2 years; men: 46.7%) were included this prospective UK Biobank study. Sarcopenia (low handgrip strength, low muscle mass...
Oral pH and inflammatory targeted system MBSH@CA could deliver the biologics to macrophages alleviate UC symptoms by regulating macrophage polarization, decreasing permeability of intestinal barrier suppressing oxidative stress.
Developing anti-viral therapies targeting HIV-1 transcription has been hampered by the limited structural knowledge of proteins involved. hijacks cellular machinery that controls RNA polymerase II elongation through an interaction Tat with positive factor P-TEFb, which interacts AF4 family member (AFF1/2/3/4) in super complex (SEC). Because inclusion Tat•P-TEFb into SEC is critical for HIV transcription, we have determined crystal structure Tat•AFF4•P-TEFb containing (residues 1–48), human...
Due to the limitations of strategies for its early diagnosis and treatment, pancreatic cancer (PC) remains a substantial human health threat. We previously discovered methylation-mediated lncRNA, LINC00261, which is downregulated in PC tissues. However, underlying role LINC00261 largely unknown.
To investigate the regulatory effect of long non-coding ribonucleic acid (lncRNA) FER1L4 on biological behaviors esophageal squamous cell carcinoma (ESCC) cells, such as proliferation and invasion.The expressions were detected in 42 pairs ESCC tissues corresponding para-carcinoma 5 kinds lines via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Polyethyleneimine (PEI) liposomes used for expression or interference elimination assays, respectively. The invasion cells...
The eukaryotic B-family DNA polymerases include four members: Polα, Polδ, Polϵ, and Polζ, which share common architectural features, such as the exonuclease/polymerase C-terminal domains (CTDs) of catalytic subunits bound to indispensable B-subunits, serve scaffolds that mediate interactions with other components replication machinery. Crystal structures for B-subunits Polα Polδ/Polζ have been reported: former within primosome separately CTD latter N-terminal domain C-subunit. Here we...
Doppler shift induced crosstalk (DSC) is an intrinsic type of channel in ultra-weak fiber Bragg grating (uwFBG) based distributed acoustic sensing (DAS) system, and has significant impact on the system's performance. This paper studies characteristics DSC uwDAS system. The origin theoretically analyzed. Accordingly,the relationship between vibration phase signal derived, which reveals that amplitude linearly proportional to frequency signal. Furthermore, irrelevance distribution...
Cardiovascular death (CVD) represents a significant determinant affecting the long-term survival outcomes of cancer patients, independent primary tumor effects. Consequently, this study aims to identify prognostic factors in patients with bone diffuse large B-cell lymphoma (PB-DLBCL) using CVD as competing risk and develop nomogram. Data for diagnosed PB-DLBCL from 2000 2015 were sourced Surveillance Epidemiology, End Results (SEER) database total 1,224 eventually included study. The...
Background Many studies have reported that N6-methyladenosine (m6A) modification plays a critical role in the epigenetic regulation of organisms and especially pathogenesis malignant diseases. However, m6A research has mainly focused on methyltransferase activity mediated by METTL3, few METTL16. The aim this study was to investigate mechanism METTL16, which mediates modification, its pancreatic adenocarcinoma (PDAC) cell proliferation. Methods Clinicopathologic survival data were...
Transmembrane protease serine 4 (TMPRSS4) is upregulated in various kinds of human cancers, including pancreatic cancer. However, its biological function ductal adenocarcinoma (PDAC) remains unclear. In the current study, real-time qPCR, immunohistochemical staining, Western blotting, and database (Cancer Genome Atlas Gene Expression) analysis revealed remarkable overexpression TMPRSS4 PDAC tissue as compared to non-tumor tissue. The was associated with poor prognosis patients. Moreover,...
Human primase synthesizes RNA primers and transfers them to the active site of Pol α with subsequent extension dNTPs. is a heterodimer two subunits: small catalytic subunit (p49) large (p58). The structural details initiation elongation steps primer synthesis, as well length counting, are not known. To address these questions, studies human were initiated. Two types crystals obtained. best diffracting belonged space group P1, unit-cell parameters = 86.2, b 88.9, c 94.68 Å, 93.82, β 96.57, γ...
Bruton's tyrosine kinase inhibitors (BTKis) are targeted treatments for B-cell tumors but have significant side effects. This study assesses and contrasts the effects of BTKis alone its four combination therapies.
Abstract Background C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid the traditional Chinese herb Sophora flavescens Ait, has been shown to inhibit cellular proliferation induce apoptosis various cancer cells. The present study investigated effects possible mechanisms matrine inhibiting growth Methods on proliferation, expression apoptotic molecules, STAT3, LMP1, RUNX3, EZH2 activation...
Abstract Background C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait. It possesses anti-cancer property through inhibiting the cell proliferation and inducing apoptosis. The present study aimed to explore underlying mechanisms of matrine suppressing growth DLBCL. Methods influence on viability cultured DLBCL lines SU-DHL-16 OCI-LY3 cells were determined by CCK-8. Apoptosis cycle...