A5001257378- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Atrial Fibrillation Management and Outcomes
- Hip disorders and treatments
- Anesthesia and Pain Management
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrhythmias and Treatments
- Cancer Cells and Metastasis
- Physics of Superconductivity and Magnetism
- RNA modifications and cancer
- Foot and Ankle Surgery
- Knee injuries and reconstruction techniques
- Heart Failure Treatment and Management
- Bone and Joint Diseases
- Bone fractures and treatments
- Cancer-related Molecular Pathways
- Acupuncture Treatment Research Studies
- Brain Metastases and Treatment
- Venous Thromboembolism Diagnosis and Management
- Lower Extremity Biomechanics and Pathologies
- Cardiac Health and Mental Health
- Prostate Cancer Treatment and Research
Nanjing General Hospital of Nanjing Military Command
2019-2025
Nanjing Medical University
2025
Wannan Medical College
2025
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2020-2024
Tianjin People's Hospital
2017-2023
Tianjin University
2017-2023
Tianjin Hospital
2015-2023
Huashan Hospital
2019-2023
Fudan University
2005-2023
Polycomb repressive complex 2 (PRC2) mediates gene silencing through histone H3K27 methylation. PRC2 components are over-expressed in metastatic prostate cancer (PC), and required for stem cell (CSC) self-renewal. 3-Dezaneplanocin-A (DZNeP) is an inhibitor of with broad anticancer activity.we investigated the effects DZNeP on proliferation, tumorigenicity invasive potential PC lines (LNCaP DU145).Exploring GEO Oncomine databases, we found that specific genes (EED, EZH2, SUZ12) predict poor...
Pancreatic cancer is the fourth leading cause of cancer-related mortality in world. can be localized, locally advanced, or metastatic. The median 1- and 5-year survival rates are 25% 6%, respectively. Epigenetic modifications such as DNA methylation play a significant role during both normal human development progression. To investigate epigenetic regulation genes tumor-initiating population pancreatic cells, which also termed stem cells (CSCs), we conducted arrays PANC1 HPAC cell lines...
Abstract Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape characterize oncogenic drivers of esophageal squamous cell carcinoma (ESCC). found 98% CpGs are hypomethylated across ESCC genome. Hypo-methylated regions enriched in areas with heterochromatin binding markers (H3K9me3, H3K27me3), while hyper-methylated polycomb repressive complex (EZH2/SUZ12) recognizing regions. Altered...
Background and Aim: Hairy enhancer of split-1 (HES1) is a downstream transcriptional factor Notch signaling pathway, which was found to be related chemoresistance. This study aimed investigate the role HES1 in chemoresistance colorectal cancer (CRC). Methods: Tissue microarray used analyze clinical significance radical resected (R0) stage II/III CRC patients that received adjuvant chemotherapy. 5-fluorouracil (5-Fu) examined cell lines (RKO HCT8, LOVO) with stable over-expression inhibition...
Background An increasing number of patients with chronic heart failure (CHF) are demanding more convenient and efficient modern health care systems, especially in remote areas away from central cities. Telehealth is receiving attention, which may be useful to CHF. Objective This study aimed evaluate the feasibility a hospital-community-family (HCF)–based telehealth program, was designed implement hierarchical management Methods single-arm prospective 70 CHF participated HCF-based program for...
Abstract Objectives Large bone defects are a common, debilitating clinical condition that have substantial global health and economic burden. Bone tissue engineering technology has become one of the most promising approaches for regenerating defective bones. In this study, we fabricated naringin‐inlaid composite silk fibroin/hydroxyapatite (NG/SF/HAp) scaffold to repair defects. Materials Methods The salt‐leaching was used fabricate NG/SF/HAp scaffold. cytocompatibility assessed using...
Cheek acupuncture therapy is a micro needling technique that involves stimulating specific points on the cheek to treat pain. It’s based three major theoretical systems: holography, Da San Jiao and physical/mental integration. Microneedles are inserted into acupoints cheek. In this case provided immediate pain relief posttraumatic injuries of lumbar spine bilateral wrists achieved clinical remission after only one time’s acupuncture. Follow up at 3, 12 24 months injuries, her headaches were...
The study was to assess the myocardial protection effects of histidine-tryptophan-ketoglutarate (HTK) solution and 4:1 blood cardioplegia (BC) in patients with atrial fibrillation (AF) who were subjected valvular replacement concomitant Cox maze III surgery. A cohort 148 individuals afflicted AF, received valve surgery conjunction procedure at our clinic within period extending from 2015 2023, enrolled. Subsequent adjustment by propensity score matching (PSM), categorized into two distinct...
<title>Abstract</title> <italic>Drosophila</italic> cryptochrome (dCry) is a flavin-containing photoreceptor that entrains the circadian clock with light. The C-terminal tail (CTT) release upon illumination crucial step for light signal transduction of dCry. Here, we demonstrated both anionic semiquinone (asq) and hydroquinone (hq) formed during (the latter only obtained in dCry mutants) could trigger CTT release. Meanwhile, neutral (nsq) formation suppressed However, it was observed...
Abstract Background The monocyte/high-density lipoprotein ratio (MHR) has emerged as a promising alternative biomarker in the fields of cardiovascular disease and atrial fibrillation (AF). This retrospective study was aimed to explore predictive value MHR for late recurrence AF after radiofrequency ablation. Methods From April 2015 October 2018, patients with paroxysmal who had undergone catheter ablation at Subei People’s Hospital Jiangsu Province were enrolled our study. All participants...
Cancer arises from the accumulation of genetic mutations and aberrant epigenetic modifications in normal cells.Cancer stem cells (CSCs) have been described as a unique tumorigenic population within tumor mass that ability to self-renew differentiate.In past few years, existence nature CSCs has served one most controversial topics field cancer biology; however, more recently, there is an abundant amount evidence demonstrates their existence.CSCs are believed be responsible for resistance...