A5058888317- Oral microbiology and periodontitis research
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Dental Health and Care Utilization
- Periodontal Regeneration and Treatments
- Endodontics and Root Canal Treatments
- Musculoskeletal pain and rehabilitation
- TGF-β signaling in diseases
- Mesenchymal stem cell research
- Dental Anxiety and Anesthesia Techniques
- Circular RNAs in diseases
- Temporomandibular Joint Disorders
- RNA Research and Splicing
- RNA modifications and cancer
- Concrete and Cement Materials Research
- Dental Radiography and Imaging
- MicroRNA in disease regulation
- dental development and anomalies
- Biomarkers in Disease Mechanisms
- Dermatological and COVID-19 studies
- Ferroptosis and cancer prognosis
- Salivary Gland Disorders and Functions
- Genetic factors in colorectal cancer
- Bone Tissue Engineering Materials
- Streptococcal Infections and Treatments
Shanghai Pulmonary Hospital
2021-2024
Tongji University
2021-2024
Second Xiangya Hospital of Central South University
2017-2024
Central South University
2017-2024
Nanyang Institute of Technology
2021-2023
Xiangya Hospital Central South University
2022
Eye & ENT Hospital of Fudan University
2022
First Affiliated Hospital of Jinan University
2022
Jiangsu Academy of Agricultural Sciences
2022
Oil Crops Research Institute
2022
Abstract Objectives Large bone defects are a common, debilitating clinical condition that have substantial global health and economic burden. Bone tissue engineering technology has become one of the most promising approaches for regenerating defective bones. In this study, we fabricated naringin‐inlaid composite silk fibroin/hydroxyapatite (NG/SF/HAp) scaffold to repair defects. Materials Methods The salt‐leaching was used fabricate NG/SF/HAp scaffold. cytocompatibility assessed using...
Bone defects are a common challenge in the clinical setting. tissue engineering (BTE) is an effective treatment for problem of large bone defects. In this study, we fabricated silk fibroin (SF)/hydroxyapatite (HAp) scaffolds inlaid with naringin poly lactic-co-glycolic acid (PLGA) microspheres, investigating feasibility their application BTE. Naringin PLGA microspheres were manufactured and adhered to SF/HAp scaffold. mesenchymal stem cells (BMSCs) inoculated onto scaffold containing...
The mechanisms underlying the two-way relationship between diabetes mellitus (DM) and periodontitis are unclear. We examined a possible effect of galectin-3 (Gal-3), factor in DM bone metabolism, on with or without DM. Using enzyme-linked immunosorbent assay, we detected saliva Gal-3 patients periodontitis, type 2 (T2DM). In animal models, measured periodontal microarchitecture via micro computed tomography, Gal-3, Runt-related transcription (Runx2), interleukin-6 (IL-6) expression alveolar...
Insulin promotes bone formation via a well-studied canonical signaling pathway. An adapter in this pathway, insulin-receptor substrate (IRS)-1, has been implicated the diabetic osteopathy provoked by impaired insulin signaling. To further investigate IRS-1's role metabolism, we generated Irs-1-deficient Irs-1smla/smla mice. These null mice developed spontaneous mutation that led to an increase trabecular thickness (Tb.Th) 12-mo-old, but not 2-mo-old Analyses of marrow stromal cells (BMSCs)...
Abstract The effects of Easydo Activator (EA), a new sonic irrigation system, on sealer penetration at the root apex were compared to needle (NI) and passive ultrasonic (PUI) in this study. Forty-two single-rooted teeth prepared randomly divided into three groups (n = 14): group 1: NI; 2: PUI; 3: EA. A solution 3% sodium hypochlorite (NaOCl) was used for irrigation. Nine each filled with AH Plus mixed CY5 fluorescent dye single gutta-percha cone. area, maximum depth percentage 5 mm 1 from...
This study explored the mechanism underlying stimulation of collagen synthesis and osteoblastic differentiation by insulin‐like growth factor 1 ( IGF 1) in primary mouse osteoblasts. Primary calvarial osteoblasts were cultured treated with various doses before transfection si RNA targeting type I alpha 2 Col1a2 ) or La ribonucleoprotein domain family member 6 Larp6 genes. Alkaline phosphatase ALP activity, osteocalcin staining, alizarin red quantification expression level runt‐related...
Paxillin (PXN) is a protein involved in numerous physiological processes, and its presence closely related to the occurrence development of many types tumors. However, no studies have analyzed PXN from pan-cancer perspective. We expression, immune cell infiltration, prognosis, biological function across different tumors included The Cancer Genome Atlas Gene Expression Omnibus datasets. results showed that expression varies strongly correlated with prognosis patients tumors; higher usually...
Transforming growth factor-beta-induced (TGFBI) protein has important roles in tumor growth, metastasis, and immunity. However, there is currently no pan-cancer evidence regarding TGFBI. In this study, we conducted a analysis of TGFBI mRNA expression prognoses various cancer types using public databases. We also investigated the associations with microenvironment (TME) components, immune cell infiltration, mutational burden (TMB), microsatellite instability (MSI), along genetic alteration...
Abstract Background The Oral Health-related Quality of Life (OHRQoL) is a multi-dimensional concept commonly used to examine the impact health status on quality life, and Health Impact Profile-14 (OHIP-14) questionnaire good self-assessment tool. This study was designed investigate factor structure OHIP-14 scale Chinese version, measurement invariance latent mean differences across genders among college students. Methods online survey completed by 919 confirmatory analysis (CFA) check...
Bone healing in tooth extraction sockets occurs a complex environment containing saliva and many microorganisms is affected by factors. Endoplasmic reticulum (ER) stress affects bone metabolism, but the role of ER after remains unclear. We utilized rat model, which we promoted wound using salubrinal to regulate response. Western blot analysis showed increased expression p-eIF2α/eIF2α, Runx2 alkaline phosphatase (ALP) tissue, histological assays irregularly arranged new with more collagen...
Periodontitis is a globally prevalent disease that imposes functional and aesthetic burden on patients. The oral microbiome influences human health. aim of this study was at assessing gender variation in the subgingival bacterial elderly patients with initial periodontitis to determine causes variation. Twelve males twenty females (range 50-68 years old) provided plaque samples. 16S rRNA gene sequencing, QIIME-based data processing, statistical analyses were carried out using several...
The highly conserved homology cassette family (HOX) as well 18 referenced long non-coding antisense transcripts (HOXATs) play vital roles in the development of some cancers. Nevertheless, their expression patterns association with cancer prognosis and tumor microenvironment (TME) pan-cancers are still unclear. Here, based on public databases, levels HOXATs, prognostic potentials, correlation mutation burden (TMB), immune cell infiltration, subtype, response-related genes, stemness scores...
Abstract Clinical studies have shown that persistent hyperglycemia following oxidative stress is associated with the apoptosis of osteocytes in diabetics. Adiponectin (APN) can ameliorate stress, and its receptors been identified bone‐forming cells. However, relationship between APN osteocyte has not fully elucidated. This study aimed to investigate whether could prevent regulate reactive oxygen species (ROS) generation a high‐glucose environment. Hoechst staining fluorescence microscopy...
Objective. Periodontitis is an inflammatory disease of microbial etiology caused primarily by dysbiosis the oral microbiota. Our aim was to compare variations in composition microbiomes youths with severe periodontitis according gender. Methods. Subgingival plaque samples collected from 17 patients (11 males and 6 females) were split for 16S rRNA gene sequencing. The composition, α-diversity, β-diversity patients’ compared between females. Linear discriminant analysis effect size (LEfSe)...
Periodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified dominant bacteria and potential pathway in young women with stage-III periodontitis. Samples subgingival plaque were collected from 26 periodontitis (20 stage-I 6 stage-III). Using 16S rRNA-sequencing, we determined variation bacterial communities two groups, each group. used Kyoto Encyclopedia Genes Genomes (KEGG) database evaluate signaling pathways difference composition. The role was...
As periodontitis progresses, the oral microbiota community changes dynamically. In this study, we evaluated dominant bacteria and their roles in potential pathway young males with stage III periodontitis. 16S rRNA sequencing was performed to evaluate variations composition of between I identify each group. Function prediction obtained based on data. The inhibitor predominant for used investigate role vivo vitro. Chao1 index, Observed Species Phylogenetic Diversity (PD) whole tree values were...