A5084309692- Prostate Cancer Treatment and Research
- Genetic Associations and Epidemiology
- Molecular Biology Techniques and Applications
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Escherichia coli research studies
- Quantum Chromodynamics and Particle Interactions
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Endodontics and Root Canal Treatments
- Circular RNAs in diseases
- vaccines and immunoinformatics approaches
- High-Energy Particle Collisions Research
- Herpesvirus Infections and Treatments
- Periodontal Regeneration and Treatments
- Antibiotic Resistance in Bacteria
- Viral Infections and Immunology Research
- Bone and Joint Diseases
- Bone health and treatments
- MicroRNA in disease regulation
- Dental Radiography and Imaging
- Adipose Tissue and Metabolism
- Poxvirus research and outbreaks
Southeast University
2025
Lishui City People's Hospital
2025
Shenzhen Children's Hospital
2023-2024
Second Xiangya Hospital of Central South University
2020-2024
Central South University
2015-2024
Stomatology Hospital
2024
Peking University
2024
Guangzhou University of Chinese Medicine
2024
Atrium Health Wake Forest Baptist
2022-2024
Capital Medical University
2012-2023
The present study was undertaken to investigate antioxidant and hypolipidemic effects, as well its molecular mechanism of wild Lactobacillus plantarum FC225 isolated from fermented cabbages. scavenging activities superoxide anion radical, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) hydroxyl were enhanced by treatment. strain also attenuated hyperlipidemic status, decreased lipid peroxidation, plasma cholesterol, triglyceride low-density lipoprotein cholesterol levels in high fat diet-fed...
Resveratrol (3,5,4′-trihydroxy-trans-stilbene, Res), as a natural product and neuroprotective drug, plays important roles in the treatment of Parkinson's disease (PD). However, Res is seriously hindered by blood–brain barrier (BBB), which limits access to central nervous system. In addition, differential diagnosis PD has been considered one most challenging neurology. Herein, magnetic targeting drug nanocarrier, Fe3O4-modified liposomes (Res-lips@Fe3O4), was designed fabricated. The...
Abstract BACKGROUND Several genome‐wide association studies (GWAS) in populations of European descent have identified more than a dozen common genetic variants that are associated with prostate cancer risk. METHODS To determine whether these also risk the Chinese population, we evaluated 17 susceptibility loci population‐based case–control study from Shanghai, including 288 cases and 155 population controls. RESULTS After adjustment for age, two were significantly risk, while other 15...
The mechanisms underlying the two-way relationship between diabetes mellitus (DM) and periodontitis are unclear. We examined a possible effect of galectin-3 (Gal-3), factor in DM bone metabolism, on with or without DM. Using enzyme-linked immunosorbent assay, we detected saliva Gal-3 patients periodontitis, type 2 (T2DM). In animal models, measured periodontal microarchitecture via micro computed tomography, Gal-3, Runt-related transcription (Runx2), interleukin-6 (IL-6) expression alveolar...
Abstract Introduction Despite evidence for systemic mitochondrial dysfunction early in Alzheimer's disease (AD) pathogenesis, reliable approaches monitoring these key bioenergetic alterations are lacking. We used peripheral blood mononuclear cells (PBMCs) and platelets as reporters of function the context cognitive impairment AD. Methods Mitochondrial was analyzed using complementary respirometric intact permeabilized from older adults with normal cognition, mild (MCI), dementia due to...
A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where frequency risk allele was consistently higher cases than controls each five CGEMS populations. Genotype information for 22 obtained either directly by genotyping or indirectly...
Abstract Differentiation of committed precursor cells into the osteoblast lineage is tightly regulated by several factors, including Runx2 and BMP2. We previously reported that C terminus Hsc70-interacting protein/STIP1 homology U-Box containing protein 1 (CHIP/STUB1) negatively differentiation through promoting degradation. However, how CHIP during remains unknown. In this study, we found miR-764-5p up-expressed in calvarial progenitor cells, coupled with down-expression protein. observed...
Lower respiratory tract infections present substantial diagnostic and therapeutic challenges, negatively impacting individual health. This study aims to utilize metagenomic next-generation sequencing (mNGS) technology comprehensively explore the spectrum of pathogens, detection antibiotic resistance genes, contributing factors associated with lung infections. The mNGS data 217 patients suspected attending Respiratory Department Nanjing Lishui People's Hospital Gaochun from September 2022...
Abstract Background Three SNPs at 17q12 and four 17q24.3 were recently identified to be associated with prostate cancer risk using a genome‐wide association study. Methods We evaluated these 7 in two hospital‐based case–control study populations, including European Americans (EA; 1,563 cases 576 controls) African (AA; 364 353 controls). Results Each of the reported alleles seven more common than controls among EA AA. The differences highly significant ( P = 10 −4 ) marginally AA 0.04) for...
Abstract Purpose: Although prostate-specific antigen (PSA) is the best biomarker for predicting prostate cancer, its predictive performance needs to be improved. Results from Prostate Cancer Prevention Trial revealed overall measured by areas under curve of receiver operating characteristic at 0.68. The goal present study assess ability genetic variants as a PSA-independent method predict cancer risk. Experimental Design: We systematically evaluated all risk that were identified genome-wide...
Purpose: Diabetes is the leading cause of end-stage renal failure.The present study was undertaken to characterize effects Corni Fructus on diabetic nephropathy in streptozotocin-induced rats and their mechanisms.Materials Methods: Streptozotocin-diabetic were orally administrated with at a dose 100, 200 or 400 mg/kg body mass for 40 days.Results: Fructus-treated showed significant decreases blood glucose, urinary protein levels water consumption.Corni also reduced serum total cholesterol,...
Vaccination with different vaccines has been implemented globally to counter the continuous COVID-19 pandemic. However, vaccine-elicited antibodies have reduced efficiency against highly mutated Omicron sub-variants. Previously, we developed a protein subunit vaccine called ZF2001, based on dimeric receptor-binding domain (RBD). This administered using dosing intervals in real-world setting. Some individuals received three doses of one-month interval between each dose, due urgent clinical...
Chirality, a fundamental design feature at all levels of life organization, has shown great capability in guiding cell‐fate determination and tissue regeneration. Chirality‐directed differentiation programs involve remarkable changes transcriptional networks, yet whether epigenetic regulatory events are also required is less well understood. Herein, by combining high‐throughput m 6 A MeRIP sequencing, RIP‐qPCR, gene modulation techniques, it demonstrated that biomimetic chiral nanofibrils...