A5100411914- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
- Global Health Care Issues
- Epigenetics and DNA Methylation
- Energy, Environment, Economic Growth
- Air Quality and Health Impacts
- Video Coding and Compression Technologies
- Genetic factors in colorectal cancer
- Bone Metabolism and Diseases
- Colorectal Cancer Treatments and Studies
- Multisensory perception and integration
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Quality Function Deployment in Product Design
- Plant biochemistry and biosynthesis
- Glycosylation and Glycoproteins Research
- Advanced Biosensing Techniques and Applications
- Heat shock proteins research
- Ferroptosis and cancer prognosis
- Climate Change and Health Impacts
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Peking Union Medical College Hospital
2019-2025
Central South University
2014-2025
Hunan Cancer Hospital
2021-2025
First Affiliated Hospital of Zhengzhou University
2025
Qingdao Center of Resource Chemistry and New Materials
2021-2024
Nanjing Medical University
2024
Purdue University West Lafayette
2023-2024
Southwest University
2023-2024
Nanjing Forestry University
2024
Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) significantly attenuates activation in murine human macrophages septic mice by lowering caspase-1 cleavage interleukin-1β (IL-1β) secretion. Inhibiting PDHK reverses inflammasome-induced metabolic reprogramming, enhances autophagy, promotes mitochondrial fusion...
Background The Sustainable Development Goals (SDGs), adopted by all United Nations (UN) member states in 2015, established a set of bold and ambitious health-related targets to achieve 2030. Understanding China's progress toward these is critical improving population health for its 1.4 billion people. Methods findings We used estimates from the Global Burden Disease (GBD) Study 2016, national surveys surveillance data China, qualitative data. Twenty-eight 37 indicators included GBD 2016 were...
Abstract Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses association between and with both time-series time-stratified–case-crossover designs. The generalized additive model (GAM) conditional logistic regression were used to assess mortality. Stratified analyses performed by age, sex, diseases. A 10 μg/m 3 increment SO 2 level was associated an increase relative risk for...
Bladder cancer (BC) and Renal cell carcinoma(RCC) are the two most frequent genitourinary cancers in China. In this study, a comprehensive liquid chromatography-mass spectrometry (LC-MS) based method, which utilizes both plasma metabolomics lipidomics platform, has been carried out to discriminate global profiles of 64 patients with BC, 74 RCC, 141 healthy controls. Apparent separation was observed between (BC RCC) samples The area under receiving operator characteristic curve (AUC) 0.985...
Abstract Introduction: The focus on social determinants of health (SDOH) and their impact outcomes is evident in U.S. federal actions by Centers for Medicare & Medicaid Services Office National Coordinator Health Information Technology. disproportionate COVID-19 minorities communities color heightened awareness inequities the need more robust SDOH data collection. Four Clinical Translational Science Award (CTSA) hubs comprising Texas Regional CTSA Consortium (TRCC) undertook an inventory...
Significance Zyxin is a member of the cell–cell adhesion complex and controls cell cytoskeleton motility. Analysis from clinical samples revealed that highly expressed in colon cancer compared with normal tissue, suggesting an oncogenic role for cancer. Depletion resulted significantly impaired proliferation, migration, cellular transformation, tumor formation xenograft animal models. We also showed phosphorylated by CDK1 during mitosis. Mitotic phosphorylation required activity promoting...
To assess the characteristics and incidence of medical litigation in China potential usefulness records such as an indicator health-care quality.We investigated 13 620 cases malpractice that ended between 2010 2015 were reported to China's Supreme Court. We categorized each case according location court, year ended, specialization involved, severity injury, type allegation raised by plaintiff - including any alleged shortcomings health care received outcome litigation.The annual increased...
Renal cell carcinoma (RCC) is the second most lethal urinary cancer. RCC frequently asymptomatic and it already metastatic at diagnosis. There an urgent necessity for specific biomarkers selection diagnostic prognostic purposes. In present study, we applied liquid chromatography-mass spectrometry (LC-MS) based metabolomics to analyze urine samples of 100 RCC, 34 benign kidney tumors 129 healthy controls. Differential metabolites were analyzed investigate if could differentiate from non-RCC....
Abstract Exosomes derived from differentiated P12 cells and MSCs were proved to suppress apoptosis of neuron cells, phosphatase tensin homolog pseudogene 1 (PTENP1) was reported inhibit cell proliferation. In this study, we aimed investigate the role PTENP1 in process post‐spinal cord injury (SCI) recovery, so as evaluate therapeutic effects exosomes transfected with short hairpin RNA (shRNA), a type novel biomarkers treatment SCI. Electron microscopy used observe morphology different...
Abstract Background Circulating tumor DNA (ctDNA) offers a convenient way to monitor progression and treatment response. Because mutational profiles are highly variable from person person, fixed content panel may be insufficient track response in all patients. Methods We design ctDNA fingerprint panels specific individual patients which based on whole exome sequencing target high frequency clonal population clusters test the 313 who together have eight types (colorectal, hepatocellular,...
Fucoidan alleviated the cefoperazone-induced intestinal inflammation and microbiota dysbiosis.
In order to analyse product–service performance (PSP) during systems' (PSSs) running time, a PSP evaluation method is proposed. Interrelationship between PSS's provider and accepter defined as relationship (PSR). Concepts of network chain are put forward describe interrelationship among PSRs from different perspectives. The concept proposed evaluate PSR. Detailed indexes designed measure the five factors PSP, including quality, cost, stability reliability. A case study provided test validity...