A5101834538- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neural Engineering
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Proteoglycans and glycosaminoglycans research
- Neuroscience and Neuropharmacology Research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Circular RNAs in diseases
- Fibroblast Growth Factor Research
- Hematological disorders and diagnostics
- Intestinal Malrotation and Obstruction Disorders
- Corneal Surgery and Treatments
- Hereditary Neurological Disorders
- RNA regulation and disease
- Autoimmune and Inflammatory Disorders Research
- Ocular Disorders and Treatments
- Lymphatic System and Diseases
- Food Allergy and Anaphylaxis Research
Tongji University
2018-2025
Shanghai Skin Disease Hospital
2021-2025
Shanghai Tenth People's Hospital
2018-2022
University of Pennsylvania
2019
Shanghai Sixth People's Hospital
2013
Shanghai Jiao Tong University
2012
Background The systemic immune-inflammation index (SII) and inflammation response (SIRI) are both novel biomarkers predictors of inflammation. Psoriasis is a skin disease characterized by chronic This study aimed to investigate the potential association between SII, SIRI, adult psoriasis. Methods Data adults aged 20 80 years from National Health Nutrition Examination Survey (NHANES) (2003–2006, 2009–2014) were utilized. K-means method was used group SII SIRI into low, medium, high-level...
Abstract Aberrant RNA splicing in keratinocytes drives inflammatory skin disorders. In the present study, we found that helicase DDX5 was downregulated from lesions patients with atopic dermatitis and psoriasis, mice keratinocyte-specific deletion of Ddx5 ( ∆KC ) were more susceptible to cutaneous inflammation. Inhibition expression induced by cytokine interleukin (IL)-17D through activation CD93–p38 MAPK–AKT–SMAD2/3 signaling pathway led pre-messenger events favored production...
Abstract The skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors regulates robustness homeostasis. AhR agonists have been approved by the FDA for psoriasis treatment are in clinical trials of atopic dermatitis (AD), but underlying mechanism action remains poorly defined. Here, we report that OVOL1/Ovol1 a conserved direct transcriptional target epidermal keratinocytes. We show influences...
Significance Zyxin is a member of the cell–cell adhesion complex and controls cell cytoskeleton motility. Analysis from clinical samples revealed that highly expressed in colon cancer compared with normal tissue, suggesting an oncogenic role for cancer. Depletion resulted significantly impaired proliferation, migration, cellular transformation, tumor formation xenograft animal models. We also showed phosphorylated by CDK1 during mitosis. Mitotic phosphorylation required activity promoting...
Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells is a critical step in pathogenesis proliferative vitreoretinopathy (PVR). Some microRNAs (miRNAs) participate regulating RPE cell EMT as post-transcriptional regulators. However, function miR-194 remains elusive. Here, role PVR was investigated.Retinal layers were obtained using laser capture microdissection (LCM). Gene expression at mRNA and protein level tissues examined quantitative reverse transcription...
Disrupted N 6 -methyladenosine (m A) modification modulates various inflammatory disorders. However, the role of m A in regulating cutaneous inflammation remains elusive. Here, we reveal that and its methyltransferase METTL3 are down-regulated keratinocytes skin diseases. Inducible deletion Mettl3 murine results spontaneous increases susceptibility to with activation neutrophil recruitment. Therapeutically, restoration alleviates disease phenotypes mice suppresses human biopsy specimens. We...
Summary Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin‐33 (IL‐33) highly expressed in patients psoriasis, but its role psoriasis unknown. The aim of this study was to investigate the possible IL‐33 pathogenesis and treatment psoriasis. expression determined using enzyme‐linked immunosorbent assay, real‐time fluorescent quantitative polymerase chain reaction immunohistochemical staining. CD4 + T cells were sorted magnetic beads treated or without...
Hyaluronan (HA), a simple disaccharide unit, can polymerize and is considered primary component of the extracellular matrix, which has wide range biological functions. In recent years, HA was found on surface tumor cells. According to previous reports, differing content cell cells closely related lymph node metastases, but mechanisms mediating this process remained unclear. This research intended study analyze adhesive changes caused by interaction between its lymphatic endothelial receptor...
ABSTRACT Skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors regulates robustness homeostasis. AhR agonist in clinical trial for atopic dermatitis (AD) treatment, but the underlying mechanism of action remains ill-defined. Here we report OVOL1/Ovol1 as a conserved direct transcriptional target epidermal keratinocytes. We show that impacts regulation keratinocyte gene expression, Ovol1...
Optogenetics enables the selective activation of genetically-targeted neuronal populations using light-sensitive ion channels. Genetic strategies Cre-dependent mouse strains, especially Ai32 line expressing Channelrhodopsin (ChR2)-EYFP fusion protein, have been a popular means to drive opsin expression in cell-type specific manner. Here we report low level leaky 'off-target' (Cre-independent) ChR2-EYFP Ai32/Ai32 homozygous mice throughout nervous system. This off-target was characterized...