A5101740002- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Mesenchymal stem cell research
- Transportation Planning and Optimization
- Cytokine Signaling Pathways and Interactions
- Electric Vehicles and Infrastructure
- Hepatitis C virus research
- Cell death mechanisms and regulation
- Human Mobility and Location-Based Analysis
- Biosimilars and Bioanalytical Methods
- interferon and immune responses
- Climate Change, Adaptation, Migration
- Plant Pathogens and Fungal Diseases
- Transportation and Mobility Innovations
- Dermatologic Treatments and Research
- Long-Term Effects of COVID-19
- Autophagy in Disease and Therapy
- Lymphoma Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Phagocytosis and Immune Regulation
- Facial Rejuvenation and Surgery Techniques
- Pharmaceutical studies and practices
Tongji University
2017-2025
Shanghai Skin Disease Hospital
2021-2025
UCLouvain
2025
Ningbo University
2023
Shanghai Tenth People's Hospital
2017-2022
China Pharmaceutical University
2021
Second Affiliated Hospital of Xi'an Jiaotong University
2020
University of Tsukuba
2017
BackgroundAlthough clinical trials and real-world data suggest that the risk of COVID-19 its complications is not exacerbated in patients with psoriasis treated by biological agents, evidence for this still limited.ObjectivesWe aimed to assess outcomes among Chinese IL-23 inhibitor, compare these variables receiving other therapies.MethodsA cross-sectional cohort study was conducted treatment inhibitor methods. All received a questionnaire contained questions about their treatment, symptoms,...
Abstract Background Treatment responses to biologic agents vary between patients with moderate severe psoriasis; while some achieve total skin clearance (TSC), a proportion of may only experience partial improvement. Objective This study was designed identify potential predictors for achieving TSC in psoriasis treated IL-17 inhibitors. It also aimed develop an easy-to-use calculator incorporating these factors by the nomogram predict response. Methods A 381 receiving ixekizumab were included...
Summary Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin‐33 (IL‐33) highly expressed in patients psoriasis, but its role psoriasis unknown. The aim of this study was to investigate the possible IL‐33 pathogenesis and treatment psoriasis. expression determined using enzyme‐linked immunosorbent assay, real‐time fluorescent quantitative polymerase chain reaction immunohistochemical staining. CD4 + T cells were sorted magnetic beads treated or without...
Sirtuin 1 (SIRT1) is involved in the pathogenesis of allergic asthma. This study aimed to investigate whether EX‑527, a specific SIRT1 inhibitor, exerted suppressive effects on airway inflammation mice submitted ovalbumin (OVA) inhalation. In addition, this assessed such protective role was mediated by autophagy suppression though mammalian target rapamycin (mTOR) activation. Female C57BL/6 were sensitized OVA and EX‑527 (10 mg/kg) administered prior challenge. The found that reversed...
Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are unique lymphocyte subpopulation share properties and express surface markers of both NK cells. Previous reports indicate iNKT regulate the development various inflammatory diseases. IL-17 key cytokine in pathogenesis psoriasis therapeutic target. Secukinumab fully human IgG1κ antibody targets IL-17A, thereby antagonizing biological effects IL-17....
The burden of hepatitis B virus (HBV) infection in China is high. safety and efficacy secukinumab psoriasis patients with HBV have not been fully elucidated. To investigate the China. In this retrospective study, 20 were identified, all whom had treated for ≥24 weeks Four chronic inactive infection, two occult other 14 resolved infection. HBV-DNA load markers measured at baseline Week 24 showed no viral reactivation. Nineteen normal levels liver enzymes after therapy. However, one patient...
The objective of this study was to evaluate optimal treatment regimen 308-nm excimer laser for palmoplantar pustulosis (PPP). 77 patients with PPP were randomly assigned receive low dose (2-fold MED as initial dose), medium (4-fold dose) and high group (6-fold the each patient depended on ultraviolet light sensitivity individual's skin which ranged from 0.1 0.25 J/cm2. All received three times weekly 8 weeks. Clinical evaluation based Palmoplantar Pustular Psoriasis Area Severity Index...
The influenza virus RNA genome exists as a ribonucleoprotein (RNP) complex by interacting with NP, one of virus-encoded binding proteins. It is proposed that trimeric NP functional form, but it not clear how formed and transferred to RNA. UAP56, cellular splicing factor, functions molecular chaperone for required the replication-coupled RNP formation newly synthesized viral genome, details transfer UAP56 unclear. Here we found complexed monomeric NP. Gel filtration analysis atomic force...
Abstract Background Hyaluronic acid (HA) fillers are known to be effective for the correction of facial wrinkles and folds, but there is no clinical study that compares efficacy small‐to‐medium‐particle HA large‐particle nasolabial folds (NLFs). Moreover, injection depth also plays an important role in NLFs as well improvement aesthetics. Objectives To assess efficacy, safety, durability a filler, Restylane, Yishumei, effect moderate‐to‐severe aesthetics Chinese population. Methods This...
Transportation demand models and traffic simulations, particularly in the realm of innovative activity-based models, necessitate comprehensive demographic-activity-travel data. Although cell phone data holds potential to provide detailed insights into activity-travel patterns, transportation planners often resort aggregate data, constrained by limited socio-demographic attributes because stringent privacy protection policies. This creates a significant challenge: how reconstruct traveler...
In the coordinated development of urban agglomerations in China, inter-city connections within have been gradually strengthened, with more interprovincial highways built. Given complex geological conditions, often require tunnels. The construction tunnel ventilation facilities needs to take into account types vehicle, traffic flows, and market share different vehicle powertrains using highways. This paper aims develop a method predict future on highway. builds policy cluster by analyzing...
Abstract Phaeohyphomycosis, caused by opportunistic rare fungi, has increasingly been reported in diabetic and immunosuppressed patients. Pyrenochaeta unguis‐hominis ( P. ), a member of the dematiaceae group, identified to cause human nail infection. We report case cutaneous phaeohyphomycosis female .