A5003748876- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Bone health and treatments
- Immunotherapy and Immune Responses
- Growth Hormone and Insulin-like Growth Factors
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Cancer-related gene regulation
- RNA Research and Splicing
- HIV/AIDS drug development and treatment
- Hormonal Regulation and Hypertension
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- HIV, Drug Use, Sexual Risk
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Immune Response and Inflammation
Tongji University
2020-2024
Shanghai Skin Disease Hospital
2009-2024
Augusta University
2014-2024
Xiangya Hospital Central South University
2024
Charlie Norwood VA Medical Center
2017-2020
The First People's Hospital of Changde
2018
Yunnan Center for Disease Control And Prevention
2016-2017
Nanjing Agricultural University
2014
Georgia Regents Medical Center
2014
California State University, East Bay
2012
BACKGROUND AND OBJECTIVES Adequate assessment of patients on glucocorticoid replacement therapy is great importance to avoid the consequences under or over treatment, but no simple test available for this. The aims this study were (1) assess adequacy in hypoadrenal patients, (2) correlate serum cortisol levels (cortisol day curve) with 24‐hour urine free excretion and (3) impact dose optimization markers bone formation resorption. DESIGN Cross‐sectional current a prospective effect...
Summary: Purpose: To determine whether long‐term treatment with valproate (VPA) and/or lamotrigine (LTG) in children epilepsy is associated altered growth bone metabolism. Methods: Twenty‐seven boys and 26 girls, aged 3 to 17 years (9.2 ± 3.9, mean SD), treated VPA LTG for ≥2 were evaluated growth, nutrient intakes, physical activity, mineral density (BMD), blood biochemical indices of Results: Twenty‐three (43.4%) the had a body height below 10th percentile. Z‐scores BMD –1.5 occurred 24.4%...
Epigenetic regulations, including DNA methylation, are critical to the development and progression of kidney fibrosis, but underlying mechanisms remain elusive. Here, we show that fibrosis mouse was associated with induction methyltransferases increases in global methylation alleviated by methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza). Genome wide analysis demonstrated hypermethylation 94 genes unilateral ureteral obstruction kidneys, which markedly reduced 5-Aza. Among these...
Rab monomeric GTPases regulate specific aspects of vesicle transport in eukaryotes including coat recruitment, uncoating, fission, motility, target selection and fusion. Moreover, individual proteins function at sites within the cell, for example ER, golgi early endosome. Importantly, localization subfamily members are often conserved underscoring significant contributions that model organisms such as Caenorhabditis elegans can make towards a better understanding human disease caused by...
Tubular changes contribute to the development of renal pathologies in diabetic kidney disease (DKD), including interstitial fibrosis. It is unclear how tubular cells relay signals fibroblasts. Recently, exosomes have been recognized as crucial mediators intercellular communication. We hypothesized that secreted from may stimulate fibroblasts for fibrosis DKD. In this study, we isolated and purified cortex DKD mice high glucose-treated mouse proximal cells. Compared with nondiabetic mice,...
Abstract Pustular psoriasis (PP) is a chronic inflammatory disease associated with multiple complications, often hyperthermia and hypoproteinemia, its continued progression can be life-threatening. Toll-like receptor 7 (TLR7) induces dendritic cell (DC) production of factors that exacerbate the response in PP. A membrane-bound chemokine expressed on DCs, CXC motif ligand 16 (CXCL16) overexpressed PP lesions, neutrophils express 6 (CXCR6). There are few studies immune microenvironment it...
The skeletal risks of subclinical hyperthyroidism in postmenopausal women on replacement thyroxine remain controversial. aims this study were to determine (1) the relationship between bone turnover and TSH levels (2) whether reduction (T4) dose who have suppressed is beneficial mineral density (BMD) turnover.A prospective over 2 years post-menopausal treated with T4 an age- sex-matched healthy control group.Sixty-four women, ages 47 74 (61 +/- 9, mean SD), for 14 years. Patients divided into...
Psoriasis is a chronic, inflammatory skin disease, frequently associated with dyslipidemia. Lipid disturbance in psoriasis affects both circulatory system and cutaneous tissue. Epidermal Langerhans cells (LCs) are tissue-resident DCs that maintain immune surveillance mediate various disorders, including psoriasis. However, the role of LCs development their lipid metabolic alternation remains unclear. Here, we demonstrate epidermal patients enlarge longer dendrites possess elevated IL-23p19...
Disrupted N 6 -methyladenosine (m A) modification modulates various inflammatory disorders. However, the role of m A in regulating cutaneous inflammation remains elusive. Here, we reveal that and its methyltransferase METTL3 are down-regulated keratinocytes skin diseases. Inducible deletion Mettl3 murine results spontaneous increases susceptibility to with activation neutrophil recruitment. Therapeutically, restoration alleviates disease phenotypes mice suppresses human biopsy specimens. We...
Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are unique lymphocyte subpopulation share properties and express surface markers of both NK cells. Previous reports indicate iNKT regulate the development various inflammatory diseases. IL-17 key cytokine in pathogenesis psoriasis therapeutic target. Secukinumab fully human IgG1κ antibody targets IL-17A, thereby antagonizing biological effects IL-17....