A5076317415- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Hidradenitis Suppurativa and Treatments
- Gout, Hyperuricemia, Uric Acid
- Colorectal and Anal Carcinomas
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Circular RNAs in diseases
- melanin and skin pigmentation
- Extracellular vesicles in disease
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Molecular Biology Techniques and Applications
- Dermatologic Treatments and Research
- Atherosclerosis and Cardiovascular Diseases
- Skin Protection and Aging
Henry Ford Health System
2016-2025
Michigan State University
2023-2025
Wayne State University
2014-2025
Henry Ford Health + Michigan State University Health Sciences
2024-2025
Henry Ford Hospital
2012-2024
Michigan United
2012-2024
Central South University of Forestry and Technology
2024
Central South University
2024
Advanced Dermatology
2022
Nanfang Hospital
2019
Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that was inhibited DKD models human kidneys. Ablation autophagy-related gene 7 (Atg7) from proximal tubules led to deficiency worse renal hypertrophy, tubular damage, inflammation, fibrosis, albuminuria mice, indicating a protective DKD. Autophagy impairment associated with downregulation unc-51-like autophagy-activating kinase 1 (ULK1),...
Cisplatin is one of the most effective anti-cancer drugs; however, use cisplatin limited by its toxicity in normal tissues, particularly injury kidneys. The mechanisms underlying therapeutic effects cancers and side tissues are largely unclear. Recent work has suggested a role for p53 cisplatin-induced renal cell apoptosis kidney injury; signaling pathway leading to activation unknown. Here we demonstrate an early DNA damage response during treatment cells tissues. Importantly, response,...
MicroRNAs are endogenous, noncoding, small RNAs that regulate expression and function of genes, but little is known about regulation microRNA in the kidneys under normal or pathologic states. Here, we generated a mouse model which proximal tubular cells lack Dicer, key enzyme for production. These mice had renal histology control conditions despite global downregulation microRNAs cortex; however, these animals were remarkably resistant to ischemia-reperfusion injury (IRI), showing...
Objective: To assess mature burn scars treated with a fractional carbon dioxide laser for changes in histological architecture, type I to III collagen ratios, density of elastic tissue, and subjective measures clinical improvements.Design: Uncontrolled, prospective study patients scars, from perspective.Biopsy specimens were obtained before 2 months after 3 treatment sessions.The tissue was prepared Verhoff von Giesen (VVG) stain discern Herovici differentiate types collagen.Setting:...
Abstract Background and Objective There have been several case reports of improvement in the appearance mature burn scars following treatment with fractional CO 2 lasers. However, biochemical mechanisms responsible for these improvements not elucidated. Materials Methods Ten patients mature, full‐thickness, hypertrophic received initial a laser. Clinical was measured Vancouver Scar Scale as well Patient Observer Assessment Scale. Fresh tissue samples were obtained before 48 hours after first...
MicroRNAs are small noncoding RNAs that produced endogenously and have emerged as important regulators in pathophysiological conditions such development tumorigenesis. Very little is known about the regulation of microRNAs renal diseases, including acute kidney injury (AKI). In this study, we examined microRNA-34a (miR-34a) experimental models cisplatin-induced AKI nephrotoxicity. By Northern blot real-time polymerase chain reaction analyses, detected an induction miR-34a vitro during...
The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. loss humans during primate evolution causes their vulnerability to Thus, we generated a Uox-knockout model on pure C57BL/6J background using transcription activator-like effector nuclease (TALEN) technique. These mice spontaneously developed hyperuricemia (over 420 μmol/l) with about 40% survival up 62 weeks. Renal...
The pathogenesis of ischemic diseases remains unclear. Here we demonstrate the induction microRNA-668 (miR-668) in acute kidney injury (AKI) human patients, mice, and renal tubular cells. was HIF-1 dependent, as deficiency cells proximal tubules attenuated miR-668 expression. We further identified a functional binding site gene promoter. Anti–miR-668 increased apoptosis enhanced AKI whereas mimic protective. Mechanistically, anti–miR-668 induced mitochondrial fragmentation, blocked...
Ischemia-reperfusion injury contributes to tissue damage and organ failure in clinical settings, but the underlying mechanism remains elusive effective therapies are still lacking. Here, we identified microRNA 687 (miR-687) as a key regulator therapeutic target renal ischemia-reperfusion injury. We show that miR-687 is markedly upregulated kidney during mice cultured cells hypoxia. MiR-687 induction under these conditions was mediated by hypoxia-inducible factor-1 (HIF-1). Upon vitro,...
Abstract Gout is one of the most common types inflammatory arthritis, caused by deposition monosodium urate crystals in and around joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum concentrations. However, hyperuricemia alone not sufficient for development gout arthritis. Here we conduct a multistage GWAS Han Chinese using 4,275 male patients 6,272 normal controls (1,255 cases 1,848 were genotyped), an additional 1,644...
MicroRNAs have been implicated in ischemic AKI. However, the specific microRNA species that regulates kidney injury remains unidentified. Our previous microarray analysis revealed microRNA-489 induction kidneys of mice subjected to renal ischemia-reperfusion. In this study, we verified during AKI and further examined underlying mechanisms. Hypoxia–inducible factor–1 α deficiency associated with diminished cultured rat proximal tubular cells hypoxia tissues after ischemia-reperfusion injury....
Abstract Age-dependent bone loss has been well documented in both human and animal models. Although the underlying causal mechanisms are probably multifactorial, it hypothesized that alterations progenitor cell number or function important. Little is known regarding properties of marrow stromal cells (BMSCs) during aging process, so question whether alters BMSC/progenitor osteogenic differentiation remains unanswered. In this study, we examined age-dependent changes potential between mature...
Summary Although non‐segmental vitiligo ( NSV ) results from the autoimmune destruction of melanocytes, detailed immune mechanisms have not yet been fully elucidated. Th17 cells identified to be implicated in human diseases. In this study, frequencies peripheral blood and serum levels IL ‐17A cell‐related cytokines were examined 45 patients with active compared race‐, gender‐, age‐matched healthy controls. Our showed increased circulating cell elevated ‐17A, TGF ‐ β 1, ‐21 . Meanwhile, are...