A5101431542- Gout, Hyperuricemia, Uric Acid
- Acute Kidney Injury Research
- Systemic Lupus Erythematosus Research
- Anesthesia and Neurotoxicity Research
- Chronic Kidney Disease and Diabetes
- Health and Wellbeing Research
- Iron Metabolism and Disorders
- Multiple Myeloma Research and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Case Reports on Hematomas
- Asthma and respiratory diseases
- Dialysis and Renal Disease Management
- Chronic Disease Management Strategies
- Inflammasome and immune disorders
- Hemoglobinopathies and Related Disorders
- Renal Diseases and Glomerulopathies
- Flavonoids in Medical Research
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- Ectopic Pregnancy Diagnosis and Management
- Health disparities and outcomes
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Urticaria and Related Conditions
- Autophagy in Disease and Therapy
Qingdao University
2012-2024
Affiliated Hospital of Qingdao University
2015-2024
Guangxi Academy of Sciences
2024
Hangzhou Women’s Hospital
2020-2023
Ruijin Hospital
2014-2022
Shanghai Jiao Tong University
2006-2022
Shanghai First People's Hospital
2012-2022
Shanxi Medical University
2021
Seattle University
2021
University of Washington
2021
Abstract Gout is one of the most common types inflammatory arthritis, caused by deposition monosodium urate crystals in and around joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum concentrations. However, hyperuricemia alone not sufficient for development gout arthritis. Here we conduct a multistage GWAS Han Chinese using 4,275 male patients 6,272 normal controls (1,255 cases 1,848 were genotyped), an additional 1,644...
The prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that the general population. However, associations RLS within ESRD population are inconsistent and usually neglected dialysis centers, although it impairs life quality among patients. We aim to investigate with undergoing maintenance hemodialysis evaluate risk factors developing effect on Shanghai General Hospital unit from July 2016 October were enrolled study. was diagnosed according...
Nod-like receptor protein 3 (NLRP3), as an inflammatory regulator, has been implicated in acute kidney injury (AKI). Failed recovery after AKI can lead to chronic disease (CKD). However, the role of NLRP3 AKI-CKD transition is still unknown. A mild or severe mouse model was performed by using ischemia-reperfusion (IRI). We evaluated renal expression and phases ischemic AKI, respectively. Although serum creatinine (Cr) blood urea nitrogen (BUN) levels phase were equivalent normal baseline,...
Objective The predominant mechanism driving hyperuricemia in gout is renal uric acid underexcretion; however, the standard urate‐lowering therapy (ULT) recommendation first‐line xanthine oxidase inhibitor (XOI), irrespective of cause hyperuricemia. This comparative effectiveness clinical trial was undertaken to compare nontitrated low‐dose benzbromarone (LDBen) uricosuric XOI ULT with febuxostat (LDFeb) patients underexcretion. Methods We conducted a prospective, randomized, single‐center,...
Abstract Background An aging population poses significant challenges to health care in China. Health management has been implemented reduce the costs of care, raise service utilization, increase knowledge and improve quality life. Several studies have tried verify effectiveness achieving these goals worldwide. However, there insufficient randomized control trials (RCTs) draw reliable conclusions. The few small-scale conducted China include mostly general rather than elderly. Our study is...
Objective To investigate the effect and mechanism of SB525334 on self-renewal, migration invasion ovarian cancer stem cells. Methods ALDHhigh-expressing cells (CSCs) were isolated from human cell line SKOV-3 by flow cytometry treated with 2μg/mL for 6h. The sphere forming assay was used to detect ability self-renewal CSCs colony formation tumorigenicity in vitro. Transwell CSCs. further explore mechanism, real-time quantitative PCR mRNA protein expression TGF-β, Smad2, Smad3, phosphorylated...
We investigated the protective effect and mechanism of neutrophil gelatinase-associated lipocalin (NGAL) on rats ischemia/reperfusion (I/R) renal injury. Eighteen Sprague-Dawley male were randomly divided into three groups. Control group (n = 6) suffered left unilateral nephrectomy, I/R + NS (normal saline) NGAL subjected to 45 min right ischemia/24 h reperfusion after nephrectomy. Serum creatinine (Scr) blood urea nitrogen (Bun) measured automatic biochemistry analyzer; kidney sections...
Retinoic acid receptor alpha (RARα) plays an essential role in the regulation of many biological processes, such as hematopoietic cell differentiation, while abnormal RARα function contributes to pathogenesis certain diseases including cancers, especially acute promyelocytic leukemia (APL). Recently, oridonin, a natural diterpenoid isolated from Rabdosia rubescens, was demonstrated regulate by increasing its protein level. However, underlying molecular mechanism for this action has not been...
Purpose: To identify the population susceptible to reactive hypoglycemia and explain possible reasons for their susceptibility. Methods: Ninety-four patients were divided into normal weight, overweight obese groups before a 75-gram prolonged oral glucose tolerance test (POGTT). The incidence of (blood ≤ 3.1 mmol/L or 55 mg/dL at points 0– 4 hours) was compared among three groups, blood insulin levels monitored simultaneously from 0 - hours assess level resistance sensitivity. Furthermore,...
Abstract Gout is a chronic disease resulting from elevated serum urate (SU). Previous genome-wide association studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few been conducted Chinese descent. Here, we try to extensively investigate whether these contribute gout risk in Han Chinese. A total 2255 variants linkage disequilibrium (LD) with GWAS SU/gout associated were analyzed cohort 1255 patients and 1848 controls. Cumulative genetic score analysis was performed...
Our aim was to provide a quantitative analysis of the changes in principal determinants insulin sensitivity and secretion relation fasting plasma glucose (FPG) or 2-h (2h PG) Chinese population with wide range tolerance.A total 5728 adults spanning entire tolerance were included. Insulin measured by Matsuda index (ISI(M)) homeostasis model assessment 1/homeostasis resistance (HOMA-IR). β-Cell function adjusted assessed from disposition (DI) at early-phase DI(30) DI(120). The exponential...
Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization degradation, acts as the critical factor in regulation of metabolism. However, it is unknown whether hepcidin involved acute renal ischemia/reperfusion injury (IRI). In this study, an IRI rat model was established via right excision blood interruption for 45 min left kidney, metabolism indexes were examined investigate change analyze role during...
Objective: To explore the effect of a smart nebulizing device on rate adherence to inhaled corticosteroid (ICS) in children with positive Asthma Predictive Index. Methods: In total, 65 Index and under age 5 years who visited our hospital from October 2015 through 2016, were randomly assigned receive conventional nebulization or nebulization. The nebulizer was connected phones via an App. following information collected: ICS, frequency emergency visits hospitalizations, application...
Renal anemia is one of the most important complications in patients on maintenance hemodialysis (MHD). Telehealth-based dialysis registration systems have advantage real-time monitoring and gradually been applied to management chronic diseases.The objective our study was evaluate impact a telehealth-based system MHD terms renal control.The Red China project aimed develop based WeChat mobile platform. Demographic baseline laboratory parameters such as age, gender, primary disease, creatinine...