A5100371149- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Cardiac Imaging and Diagnostics
- Renal and Vascular Pathologies
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes Treatment and Management
- Bone health and treatments
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Gout, Hyperuricemia, Uric Acid
- Atrial Fibrillation Management and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vascular Procedures and Complications
Guangdong Academy of Medical Sciences
2016-2025
Guangdong Provincial People's Hospital
2019-2025
Southern Medical University
2015-2025
Nanchang University
2012-2025
Hegang People's Hospital
2024
Army Medical University
2018-2024
Xinqiao Hospital
2022-2024
South China University of Technology
2015-2024
Wuhan University
2018-2024
Xuzhou Medical College
2024
Rationale: Acute kidney injury (AKI) is a common critical illness in the clinic and currently lacks effective treatment options.Ischemia reperfusion (IRI) major pathogenic factor for AKI.Due to deficiency of selenium (Se) AKI patients, we intended treat IRI-induced using Se rebalancing strategy present study.Methods: Sodium selenate, ascorbic acid, bovine serum albumin (BSA) were employed prepare nanomaterials termed Se@BSA nanoparticles (NPs) simple method.Experiments with human renal...
Among patients with acute coronary syndrome and percutaneous intervention, stress hyperglycemia ratio (SHR) is primarily associated short-term unfavorable outcomes. However, the relationship between SHR long-term worsen prognosis in myocardial infarction (AMI) admitted intensive care unit (ICU) are not fully investigated, especially those different ethnicity. This study aimed to clarify association of all-cause mortality critical AMI from American Chinese cohorts.Overall 4,337 their first...
A missing link in cholesterol absorption Cholesterol is important for general health, but too much can build up artery walls and cause cardiovascular disease. Low-density lipoprotein (LDL-C) often referred to as “bad cholesterol”; keeping LDL-C within stringent limits recommended reduce the risk of heart attack stroke. Zhang et al. discovered that some individuals have an inherited frameshift mutation LIMA1 gene (also known EPLIN or SREBP3 ). The has not been linked lipid metabolism before,...
MicroRNAs have been implicated in ischemic AKI. However, the specific microRNA species that regulates kidney injury remains unidentified. Our previous microarray analysis revealed microRNA-489 induction kidneys of mice subjected to renal ischemia-reperfusion. In this study, we verified during AKI and further examined underlying mechanisms. Hypoxia–inducible factor–1 α deficiency associated with diminished cultured rat proximal tubular cells hypoxia tissues after ischemia-reperfusion injury....
Abstract Objectives This study aimed to examine the impact of pertussis on global, regional, and national levels between 1990 2019. Methods Data a global scale from 2019 were collected Global Burden Disease Study. We performed secondary analysis report epidemiology disease burden pertussis. Results During period spanning 2019, exhibited steady decline in age-standardized incidence rate (ASIR), disability-adjusted life years (ASYR), death (ASDR). Nevertheless, upon delving into an in-depth...
Objectives. We compared trends in prevalence rates of preventable cardiovascular- and diabetes-related hospitalizations between African Americans members other major US racial/ethnic groups. Methods. Standardized for 1991 to 1998 were derived from hospital census data California. Results. had significantly higher hospitalization 1991, discrepancies continued widen through 1998. Overall male female approximately 3 times angina, 7 hypertension, 8 congestive heart failure, 10 diabetes....
The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) a promising option diabetes and its complications. In this pilot clinical trial, we evaluated the safety efficacy of intravenous autologous bone marrow MSCs (ABMSC) DR.In total, 34 eyes with non-proliferative or proliferative DR (NPDR, n = 19; PDR, 15) from 17 patients were analyzed. Treatment involved one infusion 3 × 106/kg ABSMCs. patients' vital signs monitored, along immune allergic reactions....
Abnormal hemodynamics is thought to contribute the increased risk of contrast-induced nephropathy (CIN) and mortality. However, few studies focused on patients without abnormal (defined as hypotension, intra-aortic balloon pump usage) reduced left ventricular ejection fraction (LVEF < 40%). Our study was explore impact CIN mortality in with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) relative stable hemodynamics. In this observational study, we...
In 2017, approximately one in three U.S. adults reported having been told by a health care professional that they had high blood pressure (hypertension) (1). Although hypertension prevalence is well documented at national and state levels, less known about rural-urban variation county-level prevalence. To examine of self-reported antihypertensive medication use classification county, CDC analyzed data 442,641 aged ≥18 years who participated the 2017 Behavioral Risk Factor Surveillance System...
ABSTRACT Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. It curable by excision of the causative tumor. However, few cases may persist or relapse after tumor resection. We aimed to investigate rate these events and related factors. retrospectively studied TIO patients treated with surgery in tertiary hospital. was established based on pathologic examination reversion hypophosphatemia. Refractory consisted those nonremission recurrent hypophosphatemia surgery. A total 230...
This study was conducted to evaluate and update the current prevalence of risk factors for chronic kidney disease (CKD) diabetic (DKD) in a central Chinese urban population.From December 2017 June 2018, total 5231 subjects were randomly enrolled from 3 communities districts Zhengzhou. CKD defined as estimated glomerular filtration rate (eGFR) < 60 mL/min.1.73m2 or urinary albumin creatinine ratio ≥ 30 mg/g (albuminuria). Diabetic with systolic blood pressure > 140 mmHg, albuminuria an eGFR...
Abstract Aims Available evidence is incomplete and inconsistent in the outcomes of heart failure (HF) patients with preserved ejection fraction (HFpEF), mildly reduced (HFmrEF), (HFrEF). There are also limited data on proportions long‐term prognosis among three HF phenotypes China. We aimed to characterize 5 year according EF a cohort hospitalized undergoing coronary angiography southern Methods results Hospitalized were enrolled from Cardiorenal ImprovemeNt registry (CIN; ClinicalTrials.gov...
Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response without first requiring nuclear feedback. In this study, we identify diaphanous-related formin 3 (DIAPH3), an actin nucleator, a scaffold protein initiate liquid-liquid phase separation (LLPS) form abundant cytosolic phase-separated DIAPH3 (D-granules) in mammalian cells HeLa, HEK293, fibroblasts under various conditions....
AimsHypertensive and other effects of excess glucocorticoids might be in part mediated by the suppression endothelial nitric oxide synthase (eNOS) expression. We studied transcriptional biochemical mechanisms that mediate or modulate eNOS expression glucocorticoids.
Hypertension, or high blood pressure, is a major risk factor for heart disease and stroke (1). The prevalence of hypertension higher among men than women, increases with age, highest non-Hispanic blacks (blacks) (2), has been consistently in the Southeastern region United States To update estimates self-reported use antihypertensive medication, CDC analyzed data from 2017 Behavioral Risk Factor Surveillance System (BRFSS). overall (unadjusted) was 32.4% (95% confidence interval [CI] =...
Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. The number affected persons worldwide has increased from 3.7 million in 1990 to 6.8 2017 (1). more prevalent among non-Hispanic White than it other racial/ethnic groups (2). As prevalence increases with age group (2), important understand epidemiology older population. CDC analyzed 2018 Medicare data beneficiaries aged ≥67 years examine...
Abstract This paper reports the first universal and versatile database on aggregate materials for field of science research. At current stage, ( http://119.91.135.188:8080/ ) contains over 1000 entries organic material systems (mainly luminescent at stage) with a unique data structure which is designed particularly containing photophysics physicochemical properties compounds in different statuses aggregation, including dilute solution form, pristine solid‐state, stable crystalline,...
Fuel substrate switching between carbohydrates and fat is essential for maintaining metabolic homeostasis. During aerobic exercise, the predominant energy source gradually shifts from to fat. While it well known that exercise mobilizes storage adipose tissues, remains largely obscure how circulating lipids are distributed tissue-specifically according distinct requirements. Here, we demonstrate linked nutrient availability regulate tissue-specific activities of lipoprotein lipase (LPL), key...
No well-defined protocols currently exist regarding the optimal rate and duration of normal saline administration to prevent contrast-induced acute kidney injury (CI-AKI) in patients with renal insufficiency.