A5075286593- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Anesthesia and Neurotoxicity Research
- Atrial Fibrillation Management and Outcomes
- Birth, Development, and Health
- Peptidase Inhibition and Analysis
- Intensive Care Unit Cognitive Disorders
- Circadian rhythm and melatonin
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Trauma Management and Diagnosis
- Erythropoietin and Anemia Treatment
- Anatomy and Medical Technology
- Eicosanoids and Hypertension Pharmacology
- Acute Myocardial Infarction Research
- Infectious Aortic and Vascular Conditions
- Esophageal and GI Pathology
- Cardiac Structural Anomalies and Repair
Nanjing General Hospital of Nanjing Military Command
2014-2025
Nanjing Medical University
2024-2025
Nanjing University
2010-2024
Nanjing Forestry University
2022
Southern Medical University
2021
University of California, San Diego
2021
Jinling Institute of Technology
2017-2020
University of Zurich
2018
University Hospital of Zurich
2017
Nanjing University of Aeronautics and Astronautics
2008
Abstract Non‐small cell lung cancer ( NSCLC ) accounts for most cancer. To develop new therapy required the elucidation of pathogenesis. The deubiquitinating enzymes USP 28 has been identified and studied in colon breast carcinomas. However, role is unknown. level mRNA or protein were measured by qRT ‐ PCR immunohistochemistry IHC ). patient survival was revealed K aplan– M eier plot overall patients. up down regulated overexpression plasmid si RNA transfection. Cell proliferation apoptosis...
Objective: Based on the findings that erythropoietin (EPO) has been proved to be a multiple functional cytokine attenuate ischemia–reperfusion (I/R) injury in various organs such as brain, heart, and kidney animals, this experiment was designed evaluate effect of pretreatment with recombined human (rhEPO) I/R-induced lung injury. Methods: Left lungs rats underwent 90 min ischemia then were reperfused for up 2 h. Animals randomly divided into three experimental groups sham group, I/R rhEPO +...
Lung cancer is the lead cause of cancer-related mortality around world. Non-small cell lung (NSCLC) accounts for nearly 85% all case cancer. Accumulating evidence revealed importance miRNAs in pathogenesis NSCLC. Whether miR-4500 promotes NSCLC or not still unknown. The potential targeted genes needed to be investigated.The level was measured by qRT-PCR. role patient survival Kaplan-Meier plot overall patients. up down regulated mimics ASO transfection. Cell proliferation and apoptosis were...
The study was to assess the myocardial protection effects of histidine-tryptophan-ketoglutarate (HTK) solution and 4:1 blood cardioplegia (BC) in patients with atrial fibrillation (AF) who were subjected valvular replacement concomitant Cox maze III surgery. A cohort 148 individuals afflicted AF, received valve surgery conjunction procedure at our clinic within period extending from 2015 2023, enrolled. Subsequent adjustment by propensity score matching (PSM), categorized into two distinct...
This paper presents a D-band 2-channel dual downconversion receiver front-end with sliding IF architecture in 22nm FDSOI process. A fully-differential low-noise amplifier (LNA) followed by an active double-balanced mixer is first used and down-converts the 137–157 GHz RF signal to intermediate frequency (IF) of 31–40 GHz. The split into I Q channels down-converted zero-IF output I/Q signals using passive for low 1/f noise. x6 LO (17.5 35 105 GHz) chain included on chip provides required both...
Abstract: Acute renal dysfunction is a frequent complication after cardiac surgery with cardiopulmonary bypass (CPB). This study was designed to evaluate the potential protective effect of melatonin on CPB‐induced damage in rat model. Forty male Sprague–Dawley rats were randomly divided into four groups: sham, control (CPB + placebo), low dose 10 mg/kg melatonin) and high 20 melatonin). Blood samples collected at beginning, end CPB, 0.5, 1, 2, 3, 24 hr postoperation. Serum creatinine blood...
To investigate microvascular injury quantitatively in the small bowel with respect to cardiopulmonary bypass (CPB) and related mechanisms.In 10 male SD rats, normothermic CPB was established continued a flow rate of 100-150 mL/kg per minute for 60 min, while another sham-operated animals served as controls. An approximate 10-cm loop terminal ileum exteriorized observation by means intravital fluorescence microscopy. The microcirculatory network including arterioles, capillaries, collecting...
To treat aortic valve disease and concomitant root with transcatheter techniques, 'composite graft' implants are required. Our goal was to assess the suitability of porcine for repair tests.Eight pig hearts explanted from domestic pigs used in experimental surgery were compared data literature on human hearts. The measured diameters included those annulus, sinuses Valsalva, coronary ostia, sinotubular junction, ascending aorta, innominate artery arch. distances ostia nadir corresponding...
BACKGROUND:The aims of this study were to investigate the effects mercaptoethanol treatment on expression mediators oxidative stress, inflammation, and extracellular matrix (ECM) degeneration in a mouse aortic dissection (AD) model. MATERIAL AND METHODS:Twenty-four 8-month-old C57BL/6J mice divided into three groups studied for two weeks: 1) Model group (N=8) underwent intraperitoneal injection angiotensin II (Ang II) (5 ml/kg) times every 24 h; 2) Treated given oral (2.5 mM); Normal...
Background: The objective of this study was to develop a porcine model mitral valve replacement (MVR) for long‐term evaluation prosthetic heart valves. Methods: Sixteen 25‐kg male Bama miniature pigs underwent MVR using St Jude Medical (21 mm). Each animal allocated an anticoagulation protocol after surgery (group I, s.c. heparin injection and warfarin ( n = 8); group II, low‐molecular‐weight 8)) followed up 20 weeks. Terminal studies were carried out on all animals having survived more than...
The HAART ring device has been introduced as a novel strategy to facilitate aortic valve repair. This rigid, elliptical aims restore normal leaflet configuration and provide annular stabilization in the setting of regurgitation. goal this preclinical study is evaluate vivo feasibility 'aortic valve-in-ring' transcatheter replacement (TAVR).Six animals {landrace pigs, 87.6 [standard deviation (SD) 4.5] kg} underwent implantation (5 cases #19 mm 1 case #21 mm) via full sternotomy with...