A5049296124- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Cerebrovascular and genetic disorders
- Neurological and metabolic disorders
- Mobile Health and mHealth Applications
- Clostridium difficile and Clostridium perfringens research
- Innovations in Medical Education
- Labor market dynamics and wage inequality
- Education Systems and Policy
- Infection Control in Healthcare
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Nosocomial Infections in ICU
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Telemedicine and Telehealth Implementation
- Cerebrospinal fluid and hydrocephalus
- Pediatric health and respiratory diseases
- Meta-analysis and systematic reviews
- Congenital Diaphragmatic Hernia Studies
- Vascular Malformations Diagnosis and Treatment
- Reflective Practices in Education
- Lanthanide and Transition Metal Complexes
- Commonwealth, Australian Politics and Federalism
University of Waikato
2022-2025
University of Edinburgh
2015-2024
Odense University Hospital
2024
NHS Lothian
2013-2024
University of Southern Denmark
2024
Edinburgh College
2021-2022
Massachusetts General Hospital
2021
Broad Institute
2021
Campbell Collaboration
2021
Edinburgh Royal Infirmary
2010-2016
Identification of lobar spontaneous intracerebral haemorrhage associated with cerebral amyloid angiopathy (CAA) is important because it a higher risk recurrent than arteriolosclerosis-associated haemorrhage. We aimed to develop prediction model for the identification CAA-associated using CT features and genotype.
Patients with stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) are at risk of recurrent ICH, ischaemic stroke, and other serious vascular events. We aimed analyse these risks in population-based studies compare them the RESTART, which assessed antiplatelet therapy after ICH.
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding therapy. Brain imaging features and cerebral small vessel diseases (such as microbleeds) are associated greater risks haemorrhage. We did subgroup analyses to explore whether these brain modify effects
Rationale The Boston criteria are used worldwide for the in vivo diagnosis of cerebral amyloid angiopathy and basis clinical decision-making research field. Given substantial advances angiopathy's aspects MRI biomarkers, we designed a multicenter study within International Association aimed at further validating diagnostic accuracy potentially improving updating them. Aim We aim to derive validate an updated “version 2.0” across spectrum angiopathy-related presentations biomarkers. Sample...
<h3>Importance</h3> The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up 5 years after intracerebral hemorrhage (ICH) had occurred during antithrombotic (antiplatelet anticoagulant) therapy. <h3>Objectives</h3> To monitor adherence, increase duration of follow-up, and improve precision estimates the effects on recurrent ICH major vascular events. <h3>Design, Setting Participants</h3> From May 22, 2013, through 31, 2018, this...
Medical smartphone applications are increasingly popular amongst doctors. However, the quality of their content is variable. We assessed contemporary radiology-related applications, focussing on level advertised medical involvement in application development.Six major stores were searched between 18-30 June 2012 using terms radiology, radiation, x-ray(s), computed tomography/CT, magnetic resonance imaging/MRI, ultrasound, nuclear medicine, fluoroscopy and mammography/mammogram. Application...
CT angiography (CTA) is often used for assessing patients with acute ischaemic stroke. Only limited observer reliability data exist. We tested inter- and intra-observer the assessment of CTA in stroke.We selected 15 cases from Third International Stroke Trial (IST-3, ISRCTN25765518) various degrees arterial obstruction different intracranial locations on CTA. To assess inter-observer reliability, seven members IST-3 expert image reading panel (>5 years experience CTA) radiology trainees (<2...
Spontaneous intracerebral hemorrhage (ICH) in the cerebellum has a poor short-term prognosis, whereas data on long-term case fatality and recurrent vascular events are sparse. Herewith, we aimed to assess recurrence rate of after first cerebellar ICH.
Type 2 diabetes (T2D) is sub-optimally managed for many in Aotearoa New Zealand, and disproportionately affects Māori Pacific peoples. In February 2021, SGLT2i/GLP1RA agents were funded use the first time with prioritisation Māori, those cardiovascular and/or renal disease or risk (CVRD). This study evaluates impact of health system factors on initiation therapy. Primary care data was collected patients T2D aged 18–75 years from four primary organisations (302 general practices) Auckland /...
Few population-based studies have assessed associations between the use of antithrombotic (platelet antiaggregant or anticoagulant) drugs and location-specific risks spontaneous intracerebral hemorrhage (s-ICH). In this study, we estimated drug risk lobar vs nonlobar incident s-ICH.
A study was undertaken to assess whether cerebral small vessel disease (SVD) computed tomographic (CT) biomarkers are associated with long-term outcome after intracerebral hemorrhage.
We report a case of an anomalous pulmonary vein on chest X-ray resembling scimitar sign in 80-year-old female undergoing investigation syncope.Multislice computed tomography (CT) with multiplanar reformatting and maximum intensity projections demonstrated aberrant right inferior coursing inferomedially towards the diaphragm before turning superiorly draining normally into left atrium.The diagnosis incidental meandering was established.The is used to review literature this rare anomaly,...
There are increasing opportunities for junior doctors to deliver teaching as well formally develop skills. Near-peer (NPT) programmes, like that established in South-East Scotland, not only provide additional learning students but also have potential benefits the teachers.Achieving multiple competencies required of both medical school and foundation programme poses significant challenges. Medical reduced exposure bedside teaching, which may be contributing concerns raised regarding clinical...
<h3>Objective</h3> To test the genetic contribution of rare missense variants in <i>COL4A1</i> and <i>COL4A2</i> which common are genetically associated with sporadic intracerebral hemorrhage (ICH), we performed variant analysis multiple sequencing data for risk ICH. <h3>Methods</h3> We across 559 Kbp at 13q34 including among 2,133 individuals (1,055 ICH cases; 1,078 controls) United States–based 1,381 (192 1,189 from Scotland-based cohorts, followed by sequence annotation, functional impact...
Objective To determine whether the presence of diffusion-weighted imaging-positive (DWI+) lesions is associated with recurrent stroke after intracerebral haemorrhage (ICH). Methods The REstart or STop Antithrombotics Randomised Trial (RESTART) assessed effect restarting versus avoiding antiplatelet therapy ICH on major vascular events for up to 5 years. We rated DWI sequences MRI done before randomisation DWI+ lesion presence, masked outcome and use. Cox proportional hazards regression...
CT coronary artery calcium scoring (CACS) is additive to traditional risk factors for predicting future cardiac events but associated with relatively high radiation doses. We assessed the feasibility of CACS dose reduction using a lower tube current and iterative reconstruction (IR).Artificial noise was added raw data from 27 studies patients who were symptomatic simulate scanning (75, 50 25% original current). All performed on same scanner at 120 kVp. Data reconstructed filtered back...
Various research methods have been used to obtain skeletal fracture data and report the incidence of fractures. A large number British studies collected in emergency departments, not derived from orthopaedic units. We hypothesised that will differ depending upon methodology employed capture it. Two commonly sources at our institution were compared, (the Emergency Department (ED) database Orthopaedic Trauma Unit (OTU) database), using a cohort adult patients defined population as study...
Background Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume. Aims In a community-based study, we aimed to investigate the existence, strength, direction, independence of volumes on diagnostic brain CT one-year functional long-term survival. Methods We identified all adults, resident in Lothian, diagnosed with first-ever, symptomatic June 2010 May 2013 community-based, prospective inception...