Daisy Mollison
A5072643915- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Ultrasound Imaging and Elastography
- Bone and Joint Diseases
- Neurological Disorders and Treatments
- Infectious Diseases and Mycology
- Cutaneous Melanoma Detection and Management
- Plant Virus Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Systemic Sclerosis and Related Diseases
- Powdery Mildew Fungal Diseases
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Lymphadenopathy Diagnosis and Analysis
- Ultrasound and Hyperthermia Applications
- Polyomavirus and related diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
University of Edinburgh
2014-2024
Monash Health
2024
University College London
2024
Universitat Oberta de Catalunya
2024
Fundació Clínic per a la Recerca Biomèdica
2024
University of Siena
2024
UCL Biomedical Research Centre
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Amsterdam Neuroscience
2024
Vrije Universiteit Amsterdam
2024
BackgroundNeurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research identified three neuroprotective drugs acting on different axonal pathobiologies. We aimed to test efficacy these an efficient manner with respect time, cost, patient resource.MethodsWe did a phase 2b, multiarm, parallel group, double-blind, randomised placebo-controlled trial at 13 neuroscience centres UK....
CT angiography (CTA) is often used for assessing patients with acute ischaemic stroke. Only limited observer reliability data exist. We tested inter- and intra-observer the assessment of CTA in stroke.We selected 15 cases from Third International Stroke Trial (IST-3, ISRCTN25765518) various degrees arterial obstruction different intracranial locations on CTA. To assess inter-observer reliability, seven members IST-3 expert image reading panel (>5 years experience CTA) radiology trainees (<2...
Vascular risk factors (VRFs) and cerebral small vessel disease (cSVD) are common in patients with Alzheimer (AD). It remains unclear whether this coexistence reflects shared or a mechanistic relationship vascular amyloid pathologies have independent synergistic influence on subsequent AD pathophysiology preclinical stages. We investigated links between VRFs, cSVD, levels (Aβ1-42) their combined effect downstream biomarkers, that is, CSF hyperphosphorylated tau (P-tau181), atrophy, cognition....
Abstract Purpose Rim lesions, characterised by a paramagnetic rim on susceptibility-based MRI, have been suggested to reflect chronic inflammatory demyelination in multiple sclerosis (MS) patients. Here, we assess, through susceptibility-weighted imaging (SWI), the prevalence, longitudinal volume evolution and clinical associations of lesions subjects with early relapsing–remitting MS (RRMS). Methods Subjects ( n = 44) recently diagnosed RRMS underwent 3 T MRI at baseline (M0) 1 year (M12)...
<ns3:p><ns3:bold>Introduction:</ns3:bold> Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease. MS prevalence varies geographically notably high in Scotland. Disease trajectory significantly between individuals the causes for this are largely unclear. Biomarkers predictive of disease course urgently needed to allow improved stratification current modifying therapies future targeted treatments aimed at neuroprotection remyelination. Magnetic resonance imaging...
Abstract Myelin loss is associated with axonal damage in established multiple sclerosis. This relationship challenging to study vivo early disease. Here, we ask whether myelin at diagnosis by combining non-invasive neuroimaging and blood biomarkers. We performed quantitative microstructural MRI single-molecule ELISA plasma neurofilament measurement 73 patients newly diagnosed, immunotherapy naïve relapsing–remitting integrity was evaluated using aggregate g-ratios, derived from magnetization...
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain spinal cord. Fatigue common disabling symptom from MS onset, however mechanisms by which underlying processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments MS-related fatigue. MRI provides insights into
Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling respect brain tissue type yielded metabolite levels that were significantly different white matter lesions compared normal-appearing matter, suggestive higher myelin turnover (higher choline), rate...
ABSTRACT Introduction Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease. MS prevalence varies geographically notably high in Scotland. Disease trajectory significantly between individuals the causes for this are largely unclear. Biomarkers predictive of disease course urgently needed to allow improved stratification current modifying therapies future targeted treatments aimed at neuroprotection remyelination. MRI can detect activity underlying damage...
The brain reserve hypothesis posits that larger maximal lifetime growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for reserve, has been associated with reduced progression of patients early MS; however, it is unknown whether this association remains once the secondary progressive phase MS (SPMS). Our aim was to assess decreased SPMS.