A5008221977- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neurosurgical Procedures and Complications
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Acute Ischemic Stroke Management
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Epilepsy research and treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- Neurological and metabolic disorders
- Parkinson's Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Pharmacological Effects and Toxicity Studies
- Spinal Dysraphism and Malformations
- CNS Lymphoma Diagnosis and Treatment
The University of Adelaide
2023-2025
University of Edinburgh
2011-2024
Edinburgh Royal Infirmary
1991-2019
Western General Hospital
2006-2015
NHS Lothian
2015
Liverpool Heart and Chest Hospital
2010-2012
University of Liverpool
2003-2012
Liverpool Heart and Chest Hospital NHS Trust
2012
University of Oxford
2010
Istituto Giannina Gaslini
2010
A previous placebo-controlled trial has shown that biodegradable 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafers (Gliadel wafers) prolong survival in patients with recurrent glioblastoma multiforme. previously completed phase 3 trial, also placebo controlled, 32 newly diagnosed malignant glioma demonstrated a benefit those treated BCNU wafers. Because of the small number larger was performed to confirm these results. Two hundred forty were randomized receive either or at time primary...
The vein of Galen malformation is a midline arteriovenous fistula with aneurysmal dilatation the Galen. clinical details diagnosis and treatment in 13 patients such lesions together review 232 cases collected from literature are presented this report. There were 132 males, 77 females, 36 which sex was not stated. Eighty as neonates, 82 1 to 12 months old, 39 5 years 22 6 20 over age 20. most common presenting symptoms congestive cardiac failure (110 cases), raised intracranial pressure...
Although descriptive classifications of meningioma subtypes are well established, there has been inconsistency in the categorization meningiomas into benign, atypical and anaplastic groups. The aim this study was to reassess incidence (grade II) over a 10‐year period by applying World Health Organization (WHO) 2000 classification system. A secondary determine if grade II III tumours were becoming more common. Sections 314 resected between 1994 2003 retrieved from archives Western General...
Twelve patients in a series of 22 with giant intracranial aneurysms demonstrated neuroradiological features partial or total spontaneous intra-aneurysmal thrombosis. The presence this clot significantly altered the computed tomographic appearance aneurysm. Massive thrombosis did not protect against subarachnoid haemorrhage and likelihood rupture containing aneurysm was different from that non-thrombosed Although parent artery occlusion thrombosed aneurysm, massive aneurysmal leading to...
The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because differences in the distribution underlying cerebral small vessel diseases. Therefore, we investigated incidence, characteristics, and outcome lobar nonlobar ICH.In a population-based, prospective inception cohort study ICH, used multiple overlapping sources case ascertainment follow-up to identify validate diagnoses 2010 2011 an adult population 695 335.There were 128 participants with first-ever primary...
The aims of this prospective study were to investigate levels anxiety and depression in patients with a solitary intracranial neoplasm before after surgery, determine if relationships exist between high or the hemispheric location tumour, tumour type patient gender. Patients aged 17 79 years completed Hospital Anxiety Depression Scale (HAD) biopsy resective surgery. A control group non-brain-damaged subjects also HAD lumbar spinal Of 109 brain 30 16% demonstrated likely presence depression,...
Rupture of the oesophagus is a surgical emergency with significant morbidity and mortality. We present our experience in managing such patients tertiary care cardiothoracic unit.We conducted retrospective clinical review who were admitted following rupture over period 6 years (2002-2008).In unit, there 27 admissions isolated oesophagus, which 18 males nine females. The median age was 65 (range 22-87). Twenty-four (89%) presented spontaneous perforations (Boerhaave's syndrome) three (11%)...
Awake glioma surgery aims to maximize resection optimize prognosis while minimizing the risk of postoperative deficits.To evaluate oncological, functional, and employment outcomes in first cohort patients having this type at our institution determine effects any learning curve.All cases awake adult (>18 years age) were recorded between introduction technique 2011 until end 2013. Extent tumor was quantified on magnetic resonance imaging compared with objective prediction from a probability...
Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral mitochondrial function. Alterations enriched fractions from patients with were defined label-free liquid chromatography mass spectrometry. 256 mitochondrially-associated identified and 117 these markedly (fold-change ≥2) significantly altered (p ≤ 0.05). Proteins associated oxidative damage (including catalase, superoxide...
We show that people with a silent glioma have more chances to die from their gliomas than another unrelated cause. This result, combined the knowledge diffuse low‐grade remain clinically for very long period (>10 years), grounds screening and preventive treatment of glioma.
he management of low grade glioma is one the most controversial areas in clinical neurooncology.2][3] Indeed, pivotal questions about their remain unanswered.However, concept gliomas not unitary but much more a composite different challenges depending on presentation, signs, neuroradiology, perspectives neurologists, opinion neurosurgeon, and perhaps importantly, aspirations patient.It true therefore that many patients there will be dilemma what considered optimal since no good evidence base...
✓ The authors' experience with intradural and epidural recording of spinal somatosensory evoked potentials (SSEP's) during 26 cases surgery is described. techniques monitoring cord function provided good quality SSEP waveforms in patients both without neurological deficits. configuration peak latencies remained stable for up to 5 hours anesthesia nitrous oxide, halothane, fentanyl. Patterns baseline SSEP's were characteristic different segments. Distortion asymmetry these patterns seen...
✓ Computerized tomography revealed a thrombosed giant intracavernous carotid aneurysm in man who presented with ophthalmoplegia and headache. Angiography confirmed complete aneurysmal thrombosis also occlusion of the ipsilateral internal artery. Aneurysmotomy thrombectomy produced substantial reduction mass effect, symptomatic improvement. The spontaneous intracranial aneurysms is discussed.
An inverse relationship between body mass index (BMI) and the risk of lung cancer has been reported in several studies. In this study, we aimed to assess whether BMI can affect survival after resection for cancer.We reviewed patient data a 10-year period; 337 patients with ≥ 30 who underwent non-small cell were identified. This group was matched at ratio 1:1 <30 similar characteristics such as sex, age, function test, history smoking, diabetes, peripheral vascular disease, stroke, myocardial...