A5011557766- Neuroendocrine regulation and behavior
- Evolutionary Psychology and Human Behavior
- Functional Brain Connectivity Studies
- Attachment and Relationship Dynamics
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Treatment of Major Depression
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Mental Health Research Topics
- Face Recognition and Perception
- Electroconvulsive Therapy Studies
- Infant Health and Development
- Action Observation and Synchronization
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and Mental Health
- Death Anxiety and Social Exclusion
Carl von Ossietzky Universität Oldenburg
2019-2025
Klinikum Oldenburg
2023-2024
University of Bonn
2014-2023
University Hospital Bonn
2014-2023
University of Münster
2023
Oldenburger Institut für Informatik
2022
Heidelberg University
2020-2021
University Hospital Heidelberg
2020-2021
Ruhr University Bochum
2021
Krankenhaus der Augustinerinnen
2021
Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans with therapeutic potential treatment of social, cognitive, and mood disorders. However, the OT general facilitator human learning empathy unclear. The current double-blind experiments on healthy adult male volunteers investigated first whether intranasal enhanced performance feedback-guided item–category association task where either social (smiling angry faces) or nonsocial (green red lights)...
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study actually demonstrated that this modality administration increases concentrations peptide brain well blood humans. Here using combined cerebrospinal fluid (CSF) sampling subjects receiving either 24 IU (n = 11) or placebo 4) we have shown levels significantly increased both plasma CSF. However, whereas peaked at 15 min after decreased 75...
Significance Sexual monogamy is potentially costly for males, and few mammalian species along with humans exhibit it. The hypothalamic peptide oxytocin (OXT) has been implicated in mediating pair bonds various species, but as yet, we know little about neurobiological factors that might act to promote fidelity, especially men. Here provide evidence a mechanism by which OXT may contribute romantic men enhancing their partner's attractiveness reward value compared other women.
In humans, interpersonal romantic attraction and the subsequent development of monogamous pair-bonds is substantially predicted by influential impressions formed during first encounters. The prosocial neuropeptide oxytocin (OXT) has been identified as a key facilitator both formation parental attachment. However, whether OXT contributes to maintenance bonds after they have unclear. this randomized placebo-controlled trial, we provide behavioral evidence that intranasal administration...
The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may reduce that negative ones by inhibiting amygdala activation, although it is unclear whether latter causes blunted emotional and mnemonic responses. In two independent double-blind placebo-controlled experiments, each involving over 70 healthy male subjects, we investigated OXT affects modulation startle reactivity aversive stimuli as well subsequent memory for them. Intranasal potentiated acoustic...
Facilitation of social attraction and bonding by the evolutionarily conserved neuropeptide oxytocin is well-established in female mammals. However, accumulating behavioral evidence suggests that may have evolved sex-specific functional roles domain human cognition. A critical question how differentially modulates neural processing information men women, leading to divergent responses. Here we show intranasal treatment produces sex- valence-dependent increases amygdala activation when women...
The influence of emotion on human memory is associated with two contradictory effects in the form either emotion-induced enhancements or decrements memory. In a series experiments involving single word presentation, we show that enhanced for emotional words strongly coupled to items preceding stimulus, an effect more pronounced women. These would appear depend common neurobiological substrate, and are reversed by propranolol, beta-adrenergic antagonist, abolished selective bilateral amygdala...
Abstract The human amygdala is a key structure for processing emotional facial expressions, but it remains unclear what aspects of emotion are processed. We investigated this question with three different approaches: behavioural analysis 3 lesion patients, neuroimaging 19 healthy adults, and single-neuron recordings in 9 neurosurgical patients. patients showed shift sensitivity to fear, BOLD responses were modulated by both fear ambiguity (the uncertainty that expression categorized as...
Short- and long-term antidepressant effects of deep brain stimulation (DBS) in treatment-resistant depression (TRD) have been demonstrated for several targets open-label studies. For two targets, pivotal randomized trials conducted; both failed a futility analysis. We assessed efficacy safety DBS the supero-lateral branch medial forebrain bundle (slMFB) small Phase I clinical study with randomized-controlled onset order to obtain data planning large RCT. Sixteen patients suffering from TRD...
Abstract Background Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the pathogenesis of which thought to involve gene-environment interactions that might be captured in epigenome. The present study investigated epigenome-wide patterns DNA methylation (5-methylcytosine, 5mC) and hydroxymethylation (5-hydroxymethylcytosine, 5hmC), as well abundance unmodified cytosine (UC), relation AD. Results We identified epigenetic differences AD patients ( n = 45) compared...
Current perspectives on the evolutionary roots of human morality suggest it arose to incentivize social cooperation by promoting feelings disgust toward selfish behavior, although underlying neural mechanisms remain unclear.To investigate whether ancient mammalian neuropeptide oxytocin (OXT) influences self-referential processing in domains emotion evaluation and moral decision making, we conducted a pharmaco-functional magnetic resonance imaging (fMRI) behavioral experiment involving 157...