A5006451139- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Advanced Database Systems and Queries
- Genetic Associations and Epidemiology
- Cardiac Imaging and Diagnostics
- Data Management and Algorithms
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Data Mining Algorithms and Applications
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Health and Mental Health
- Target Tracking and Data Fusion in Sensor Networks
- Emergency and Acute Care Studies
- Chronic Kidney Disease and Diabetes
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Data Quality and Management
Karolinska Institutet
2016-2025
Stockholm South General Hospital
2018-2025
Karolinska University Hospital
2009-2021
Uppsala University
2018
Danderyds sjukhus
2018
Dalarna University
2015
Medical Products Agency
2015
Kent State University
2014
Swedish Defence Research Agency
1976-2009
Institute for Environmental Management
2008
In the HOPE-trial, ACE inhibitor ramipril significantly reduced cardiovascular morbidity and mortality in patients at high risk for events. The benefit could only partly be attributed to modest mean reduction of office blood pressure (OBP) during study period (3/2 mm Hg). However, because according HOPE protocol was given once daily bedtime measured day, 24-hour may underestimated based on OBP. Thirty-eight with peripheral arterial disease enrolled underwent ambulatory (ABP) measurement...
Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent creatinine-based renal function measurements. It unclear whether this relationship causal, arises from residual confounding, and/or a consequence reverse causation. The aim study was to use Mendelian randomization investigate causally related CVD in the general population. We incorporated participant data 16 prospective cohorts (n = 76,481) 37,126 measures and...
Background: The comparative efficacy and safety of ticagrelor versus clopidogrel in older patients with myocardial infarction (MI) has received limited study. Methods: We performed an observational analysis all ≥80 years (n=14 005) who were discharged alive aspirin combined either (60.2%) or (39.8%) after a MI between 2010 2017 registered the national registry SWEDEHEART (Swedish Web-System for Enhancement Development Evidence-Based Care Heart Disease Evaluated According to Recommended...
Decreased renal function is an established risk factor for cardiovascular disease (CVD). Causal mechanisms between estimates of and CVD are intricate investigation the relative importance genetic environmental factors variability these phenotypes could provide new knowledge.Cystatin C creatinine levels in 12 313 twins were analyzed. Uni- bivariate heritability traits was estimated through structured equation modelling genome-wide complex trait analysis (GCTA) order to independently confirm...
Background: The number of patients with myocardial infarction and severe obesity is increasing there a lack evidence how these should be treated. aim this study was to investigate the association between metabolic surgery (Roux-en-Y gastric bypass sleeve gastrectomy) major adverse cardiovascular events in previous (MI) obesity. Methods: Of 566 MI registered SWEDEHEART registry (Swedish Web-System for Enhancement Development Evidence-Based Care Heart Disease Evaluated According Recommended...
Background Risk assessment post-myocardial infarction needs improvement, and risk factors derived from general populations apply differently in secondary prevention. The prediction of subsequent cardiovascular events by socioeconomic status has previously been poorly studied. Design Swedish nationwide cohort study. Methods A total 29,226 men women (27%), 40–76 years age, registered at the standardised one year revisit after a first myocardial prevention quality registry SWEDEHEART 2006–2014....
Aims The risks associated with diabetes, obesity and hypertension for severe COVID-19 may be confounded differ by sociodemographic background. We assessed the cardiometabolic factors when accounting socioeconomic in subgroups age, sex region of birth. Methods results In this nationwide case–control study, 1.086 patients admitted to intensive care requiring mechanical ventilation (cases), 10.860 population-based controls matched district residency were included from mandatory national...
The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown.The purpose of this study was to investigate the prevalence its with in patients a first infarction.In register-based observational cohort, 22,882 were identified from national Swedish Web-system for Enhancement Development Evidence-based Care Heart Disease Evaluated According Recommended Therapies (SWEDEHEART) registry at clinical revisit 4-10 weeks...
Low socioeconomic status (SES) is associated with poor long-term prognosis after myocardial infarction (MI). Plausible underlying mechanisms have received limited study.To assess whether SES risk factor target achievements or risk-modifying activities, including cardiac rehabilitation programs, monitoring, and drug therapies, during the first year MI.This cohort study included a population-based consecutive sample of 30 191 one-year survivors first-ever MI who were 18 to 76 years age,...
In twin studies of cardiovascular disease biomarkers the dizygotic correlations are often estimated to be less than half monozygotic indicating a potential influence nonadditive genetic factors. Using large and homogenous sample, we additive dominance influences on levels high density lipoprotein, low apolipoprotein A-I, B, total cholesterol, triglycerides, glucose, hemoglobin Alc c-reactive protein, all which associated with disease. The blood were measured 12,000 Swedish twins born between...
In the emergency department (ED), high blood pressure (BP) is commonly observed but mostly used to evaluate patients' health in short term. We aimed study whether ED-measured BP associated with incident atherosclerotic cardiovascular disease (ASCVD), myocardial infarction, or stroke long term, and estimate number needed screen prevent ASCVD. this cohort study, participants were selected from a university hospital between 2010 2016, an obtained ED. The outcome information was acquired through...
Abstract Aims We aimed to investigate whether metabolomic profiling of blood can lead novel insights into heart failure pathogenesis or improved risk prediction. Methods and results Mass spectrometry‐based was performed in plasma serum samples from three community‐based cohorts without at baseline (total n = 3924; 341 incident events; median follow‐up ranging 4.6 13.9 years). Cox proportional hazard models were applied assess the association each 206 identified metabolites with discovery...
The value of family history coronary artery disease (CAD) in diagnosing acute syndrome (ACS) chest pain patients is uncertain, especially relation to high-sensitivity assays for cardiac troponin T (hs-cTnT), which have improved ACS diagnostics. Our objective was investigate the association between verified CAD and patients, overall different strata initial hs-cTnT.Data on visiting four emergency departments Sweden during 2013-2016 were cross-referenced with national registers kinship,...
Abstract To determine whether immigrant background and socioeconomic status were associated with increased risk to develop severe Coronavirus disease 2019 (COVID-19) requiring mechanical ventilation at the intensive care unit study their effects on 90-day mortality. Nationwide case–control personal-level data from Swedish Intensive Care register linked Statistics Sweden comorbidity national patient register. For each case of COVID-19 treated (outcome), 10 population controls matched for age,...
Abstract Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods results currently includes 51 studies from 11 countries, including 68 157 cases 949 888 controls, with data on events prognosis. All collected biological samples performed genome‐wide genotyping common genetic variants. enrolment subjects into participating ranged 1948 present day, median follow‐up following diagnosis 2...