A5034453769- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Eating Disorders and Behaviors
- Diabetes Treatment and Management
- Body Contouring and Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Obesity and Health Practices
- Obesity, Physical Activity, Diet
- Dietary Effects on Health
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Pharmacology and Obesity Treatment
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cardiovascular Function and Risk Factors
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Sleep and related disorders
Danderyds sjukhus
2010-2025
Karolinska Institutet
2015-2024
Glanrhyd Hospital
1999-2024
Uppsala University
2022
Örebro University
2020
University of Leeds
2009-2015
James Cook University Hospital
2015
Technische Universität Dresden
2015
University of Edinburgh
2015
The University of Western Australia
2015
Abstract Context: Endocrine effects of gastric bypass (GBP) surgery for obesity on glucose homeostasis are not fully understood. Main Objective: The main objective the study was to assess changes in plasma glucose, insulin, glucagon-like peptide-1 (GLP-1), leptin, somatostatin, glucose-dependent insulinotropic peptide, enteroglucagon, and glucagon early after GBP. Method: Twelve obese subjects (body mass index 45.3 ± 1.9 kg/m2) were subjected a liquid meal without lipids before 3 d, 2...
DNA methylation provides a mechanism by which environmental factors can control insulin sensitivity in obesity. Here, we assessed skeletal muscle from obese people before and after Roux-en-Y gastric bypass (RYGB). Obesity was associated with altered expression of subset genes enriched metabolic process mitochondrial function. After weight loss, the majority identified normalized to levels observed normal-weight, healthy controls. Among 14 analyzed, promoter 11 subjects. Using bisulfite...
Laparoscopic sleeve gastrectomy (SG) and laparoscopic Roux-en-Y gastric bypass (RYGB) are widely used bariatric procedures for which comparative efficacy safety remain unclear.
Ghrelin is produced primarily by enteroendocrine cells in the gastric mucosa and increases emptying patients with gastroparesis.The objective of study was to evaluate effect ghrelin on emptying, appetite, postprandial hormone secretion normal volunteers.This a randomized, double-blind, crossover study.Subjects included human volunteers GH deficiency.Intervention saline or (10 pmol/kg.min) infusion for 180 min after intake radioactively labeled omelette (310 kcal) substitution GH-deficient...
The aim of the present study was to assess effect glucagon-like peptide-1 (GLP-1) on solid gastric emptying and subsequent release pancreatic intestinal hormones. In eight men [age 33.6 ± 2.5 yr, body mass index 24.1 0.9 (means SE)], scintigraphic during infusion GLP-1 (0.75 pmol ⋅ kg −1 min ) or saline studied for 180 min. Concomitantly, plasma concentrations C- N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, peptide YY (PYY) were assessed. Infusion resulted in a profound...
The idea of body weight regulation implies that a biological mechanism exerts control over energy expenditure and food intake. This is central tenet homeostasis. However, the source identity controlling have not been identified, although it often presumed to be some long-acting signal related fat, such as leptin. Using comprehensive experimental platform, we investigated relationship between behavioural variables in two separate studies 12-week intervention period obese adults (total n 92)....
Site differences in adipose tissue function may have implications for insulin-resistant conditions. In mature tissue, subcutaneous adipocytes higher leptin secretion, similar tumor necrosis factor (TNF)-α and lower catecholamine-stimulated lipolysis as compared with omental adipocytes. this study, TNF-α secretion were between human preadipocytes. After 16 days of incubation a minimal differentiation medium, mRNA found to be two eight times than preadipocytes (P < 0.05). On the other...
Impaired oxidative phosphorylation is suggested as a factor behind insulin resistance of skeletal muscle in type 2 diabetes. The role adipose tissue was elucidated from results Affymetrix gene profiling subcutaneous and visceral eight nonobese healthy, obese diabetic women. Downregulation several genes the electron transport chain most prominent finding fat women independent obesity, but pattern distinct that previously reported A similar much weaker effect observed fat. Tumor necrosis...
The relationship between postprandial peptides at circulating physiological levels and short-term appetite control is not well understood. purpose of this study was first to compare the profiles ghrelin, glucagon-like peptide 1 (GLP-1), YY (PYY) after isoenergetic meals differing in fat carbohydrate content second examine relationships GLP-1, PYY with hunger, fullness, energy intake. Plasma collected before periodically for 180 minutes, which time ad libitum food provided. Simultaneous...
To identify risk factors for serious and specific early complications of laparoscopic gastric bypass surgery using a large national cohort patients.Bariatric procedures are among the most common surgical today. There is, however, still need to preoperative intraoperative complications.From Scandinavian Obesity Surgery Registry database, we identified 26,173 patients undergoing primary operation morbid obesity between May 1, 2007, September 30, 2012. Follow-up on day 30 was 95.7%....
<h3>Importance</h3>We demonstrate that patients who have undergone gastric bypass surgery (GBS) a higher risk of inpatient care for alcohol dependence than those restrictive surgery. This highlights need health providers to be aware this so early detection and treatment can put in place.<h3>Objective</h3>To evaluate abuse before after GBS compared with (vertical banded gastroplasty banding).<h3>Design</h3>Retrospective population-based cohort study including all underwent GBS, vertical...
Epigenetic modifications contribute to the etiology of type 2 diabetes.We performed genome-wide methylome and transcriptome analysis in liver from severely obese men with or without diabetes non-obese discover aberrant pathways underlying development insulin resistance. Results were validated by pyrosequencing.We identified hypomethylation genes involved hepatic glycolysis resistance, concomitant increased mRNA expression protein levels. Pyrosequencing revealed CpG-site within ATF-motifs was...