A5075239990- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Aortic aneurysm repair treatments
- Cardiac Health and Mental Health
- Protease and Inhibitor Mechanisms
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Antioxidant Activity and Oxidative Stress
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Advanced Radiotherapy Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
University of Otago
2016-2025
Dunedin Public Hospital
2016-2025
Southern District Health Board
2021-2025
Royal Devon & Exeter NHS Foundation Trust
2024
Johns Hopkins University
2016-2024
Aurora St. Luke's Medical Center
2024
University of Wisconsin–Madison
2024
Edinburgh College
2024
University of Edinburgh
2019-2024
Moulton College
2023
Accumulation of eosinophils in the bronchial mucosa individuals with asthma is considered to be a central event pathogenesis asthma. In animal models, airway eosinophil recruitment and hyperresponsiveness response allergen challenge are reduced by specific targeting interleukin-5. A previous small dose-finding study found that mepolizumab, humanized anti-interleukin-5 monoclonal antibody, had no effect on humans.To investigate three intravenous infusions 250 or 750 mg at monthly intervals,...
It is known that cerebral blood flow declines with age in sedentary adults, although previous studies have involved small sample sizes, making the exact estimate of decline imprecise and effects possible moderator variables unknown. Animal indicate aerobic exercise can elevate flow; however, this possibility has not been examined humans. We how regular affects age-related velocity middle artery (MCAv) healthy Maximal oxygen consumption, body mass index (BMI), pressure MCAv were measured (n =...
Previous studies examining blood pressure change over time have modeled an average population trajectory. Recent research among older adults suggests there may be subgroups with different trajectories. Identifying at risk of developing adult hypertension early in life can inform effective reduction efforts. We sought to identify systolic trajectories from childhood, their correlated factors, and early-midlife cardiovascular outcomes. Blood data ages 7, 11, 18, 26, 32, 38 years a...
Several sequence variants are known to have effects on serum levels of non–high-density lipoprotein (HDL) cholesterol that alter the risk coronary artery disease.
Abdominal aortic aneurysm (AAA) is a common human disease with high estimated heritability (0.7); however, only small number of associated genetic loci have been reported to date. In contrast, over 100 now reproducibly either blood lipid profile and/or coronary artery (CAD) (both risk factors for AAA) in large-scale meta-analyses. This study employed staged design investigate whether the these two phenotypes are also AAA. Validated CAD and dyslipidaemia underwent screening using Otago AAA...
An experimental study of cardiovascular complications that arise during vertebroplasty was conducted.To investigate the sequential occurrence fat embolism and hypotension vertebroplasty.Vertebroplasty, augmentation vertebrae with polymethylmethacrylate, is a technique for treating osteoporotic compression fractures achieving prophylactic stabilization vertebral bodies at risk fracture. However, there concern acute could occur as in variety other orthopedic procedures.In six sheep, 6 mL...
The national status of regional trauma system development was evaluated by a survey sent to all state emergency medical services directors and chairpersons the American College Surgeons Committee on Trauma. Eight essential components based criteria set forth were listed. Only two states found have statewide coverage. Nineteen District Columbia lacked one or more system. remaining 29 had yet initiate process center designation. In response these shortcomings, an attempt made define barriers...
<h3>Background:</h3> Impaired lung function is associated with systemic inflammation and a risk factor for cardiovascular disease in older adults. It unknown when these associations emerge to what extent they are mediated by smoking, chronic airways disease, and/or established atherosclerosis. We explored the association between forced expiratory volume one second (FEV<sub>1</sub>) inflammatory marker C-reactive protein (CRP) young <h3>Methods:</h3> Associations spirometric blood CRP were...
Abstract Background : Levels of anti‐oxidant polyphenols are higher in red than white wine and thought to contribute the reduced cardiovascular risk associated with moderate consumption observed epidemiological studies. Aim To compare acute effects ingestion on endothelial function subjects coronary artery disease (CAD). Methods Fourteen proven CAD were randomised consume a light meal single blind cross‐over study. Flow‐mediated dilatation (FMD) brachial was measured using high‐resolution...
Endothelium-dependent vasodilation is impaired and predicts the risk of a coronary event in patients with artery disease (CAD). Oxidant stress increased systemic inflammation may contribute to this endothelial dysfunction. Aged garlic extract (AGE) contains antioxidant compounds increases nitric oxide production decreases output inflammatory cytokines from cultured cells. The aim study was test effect treatment AGE on brachial flow mediated endothelium-dependent dilation (FMD) circulating...
The aim of this study was to compare the acute effect (i) meals rich in saturated fat, oleic acid, and alpha-linolenic acid (ii) starch fiber on markers inflammation oxidative stress obese lean women. In a crossover study, 15 abdominally women (age, 54 +/- 9 years; BMI, 37.3 5.5 kg/m2) 14 53 10 22.9 1.9 consumed cream (CR), olive oil (OL), canola (CAN), potato (POT), All-Bran (BRAN) random order. Blood samples were collected before up 6 h after plasma interleukin-6 (IL-6), IL-8, tumor...
The physiological challenge of standing upright is evidenced by temporary symptoms light-headedness, dizziness, and nausea. It not known, however, if initial orthostatic hypotension (IOH) related associated with are to the occurrence syncope. Since IOH reflects immediate adjustments compared sustained during stress, we anticipated that severity would be unrelated Following a standardized period supine rest, healthy volunteers [ n = 46; 25 ± 5 yr old (mean SD)] were instructed stand for 3...
Microangiopathy due to endothelial dysfunction is a major contributing factor the development of diabetes-induced cardiovascular disease (CVD). Dysregulation endothelial-specific microRNAs (miRs) correlated with impaired angiogenesis and cell survival. We investigated profile two angiomiRs, miR-126, miR-132, in plasma type 2 diabetic individuals without any known history CVD as well cardiac tissues collected from diabetics undergoing surgery.The presence diabetes alone significantly...
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein-like lipoprotein and important cardiovascular risk factor whose cognate receptor intracellular fate remains unknown.Our study aimed to determine the trafficking pathway for Lp(a) responsible its uptake in liver cells.Human hepatoma cells were treated with purified from human plasma studied using Western blot analysis localization of by confocal microscopy. was maximally internalized 2 hours detected an antiapo(a) antibody be localized...
Aim: Myocardial fibrosis is a well-established cause of increased myocardial stiffness and subsequent diastolic dysfunction in the diabetic heart. The molecular regulators that drive process fibrotic events heart are still unknown. We determined role microRNA (miR)-15 family remodelling Methods results: Right atrial appendage (RAA) left ventricular (LV) biopsy tissues collected from non-diabetic (ND) patients undergoing coronary artery bypass graft surgery showed significant down-regulation...