A5085600908- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Protease and Inhibitor Mechanisms
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Mechanical Circulatory Support Devices
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
Dunedin Public Hospital
2011-2025
University of Otago
2014-2024
Tufts Medical Center
2024
Centre Hospitalier de l’Université de Montréal
2024
Mercy Hospital for Women
2023
Wellington Hospital
2021
Southern District Health Board
2021
Monash Health
2020
Royal Adelaide Hospital
2016
Royal Perth Hospital
2016
Twenty two patients (four men, 18 women, mean age 56 years, range 21 to 88 years) with a history of rheumatic mitral stenosis were studied by cross sectional echocardiography before and after balloon dilatation the valve. The appearance valve on pre-dilatation echocardiogram was scored for leaflet mobility, thickening, subvalvar calcification. Mitral area, left atrial volume, transmitral pressure difference, pulmonary artery pressure, cardiac output, rhythm, New York Heart Association...
This study reports the clinical follow-up (13 +/- 1 months) of 100 consecutive patients who underwent percutaneous mitral balloon valvotomy (PMV). Echocardiographic (n = 32) and cardiac catheterization 37) data from this group are also included. Patients were divided into two groups by an echocardiographic score. PMV resulted in a good hemodynamic result (post-PMV valve area, greater than or equal to 1.5 cm2) 88% with score 8 less 44% more 8. Eighty-eight percent 57) New York Heart...
Mitral pressure half-time (T1/2) is widely used as an independent measure of mitral valve area in patients undergoing percutaneous valvotomy. However, fluid dynamics theory predicts T1/2 to be strongly dependent on chamber compliance and the peak transmitral gradient, which are variables that change dramatically with These theoretical predictions were tested vitro model left heart where area, compliance, initial gradient independently adjusted. Measured was observed vary inversely orifice...
We studied 130 patients undergoing percutaneous balloon mitral valvotomy. The relation between valvular morphology according to a previously described echocardiographic scoring system and hemodynamic outcome expressed as qualitative ("good" suboptimal) absolute change in valve area was analyzed. relative importance of the individual components this score (valvular thickening, mobility, calcification, subvalvular disease) after valvotomy also examined. Mean transmitral pressure gradient...
To investigate the natural history of regional dyssynergy and left ventricular size after myocardial infarction, 57 patients with a first Q wave infarction (18 anterior, 35 inferior, four apical by echocardiography) were studied two-dimensional echocardiography compared 30 control patients. Measurements from echocardiograms used to construct maps endocardial surface which area index (ESAi) percent involved abnormal wall motion (%AWM) calculated. The entry 3-month classify based on changes in...
The stroke volume and cardiac output changes in twenty-four patients undergoing laparoscopy were measured using the non-invasive technique of impedance cardiography. There was a moderate fall during intraperitoneal insufflation carbon dioxide which directly related to gas used. need for caution particularly ill is emphasised.
Abstract Percutaneous mitral balloon valvotomy (PMV) was performed successfully in a 41‐year‐old pregnant patient with severe stenosis. The had 21‐week gestation and severely limited by symptoms resulting from critical PMV resulted decrease the diastolic gradient 26 to 2 mm Hg an increase both cardiac output (from 4.2 5.7 I/min) valve area 0.7 3.7 cm ). She marked symptomatic improvement, no further heart failure, full‐term, normal delivery. This case report indicates that may be treatment...
The 12-month results of RESOLUTE were favourable for the new Resolute stent. Two-year safety and efficacy from have been evaluated are now reported.RESOLUTE was a prospective, multicentre, non-randomised, single-arm, controlled trial stent in 139 participants with symptomatic ischaemic heart disease due to single de novo lesions native coronary artery. 2-year rates MACE (all-cause death, myocardial infarction, emergent cardiac bypass surgery, target lesion revascularisation [TLR]), late...
ABSTRACT Type 2 diabetes is associated with reduced left ventricular reserve. It unclear whether exercise training improves function in people type diabetes. Purpose This study aimed to determine 3 months of high-intensity interval (HIIT) during adults Methods Participants performed a V˙O 2peak test and received DXA scan total blood volume measurement at baseline. Left end-diastolic (LVEDV), end-systolic (LVESV), stroke (LVSV) were then measured rest low- moderate-intensity semirecumbent...
People with type 1 diabetes (T1D) have lower exercise capacity (V̇O2max) than their age-matched nondiabetic counterparts (CON), which might be related to cardiac autonomic dysfunction. We examined whether Heart Rate Variability (HRV; indicator of modulation) was associated in those and without T1D. Twenty-three participants uncomplicated T1D 17 matched CON were recruited. rate (HR; ECG), blood pressure (BP; finger photo-plethysmography), respiratory (respiratory belt) measured during...
Abstract Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved with little effect on intracellular Ca 2+ flux. Low‐dose carbon monoxide (CO) induces effects in perfused hearts. Using the CO‐releasing pro‐drug, oCOm‐21, we investigated if this results from an increase myofilament sensitivity. Male Sprague Dawley rat left...
To evaluate the relative strengths of 3 frailty assessment instruments for predicting mortality and prolonged hospitalization in acute coronary syndrome patients. Prospective cohort study. Acute cardiac care units New Zealand. 1174 patients >70 years age hospitalized with an syndrome. The Clinical Frailty Scale (CFS), Edmonton Frail (EFS) Fried Criteria (Fried), were completed during hospital admission following when patient was clinically stable. All-cause over next ~5 >10 days year...
Catheter-based renal denervation for the treatment of drug-resistant hypertension has been intensively investigated in recent years. To date, only limited data have published using multi-electrode radiofrequency ablation systems that can deliver lesions with a pre-determined pattern. This study was designed to evaluate safety and performance second generation EnligHTN™ Renal Denervation System.This first-in-human, prospective, multi-center, non-randomized included 39 patients (62% male, mean...
Attenuated increases in ventricular stroke volume during exercise are common type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was determine whether impaired filling or systolic ejection were responsible for the attenuated reserve people with uncomplicated diabetes. Peak capacity total blood measured 17 16 non-diabetic controls no evidence cardiovascular disease. Left volumes other diastolic functional parameters echocardiography at rest semi-recumbent...
This study aimed to determine whether the plasma levels of matrix metalloproteinase-9 (MMP-9) or tissue inhibitor metalloproteinases-1 (TIMP-1) were altered in patients with a history symptomatic in-stent restenosis (ISR).A group 158 ISR compared 128 symptom-free patients. Plasma samples and detailed risk factor collected. analyzed for pro-MMP-9 latent MMP-9 active MMP-9, MMP-3, TIMP-1. Several variables associated ISR, including index coronary disease extent severity (number diseased...
Previous studies have documented the prevalence of abdominal aortic aneurysm (AAA) during transthoracic echocardiography, but effect such screening on subsequent vascular interventions remains unclear.This study aimed to determine utility opportunistic selective for AAA in a contemporary large series patients having echocardiography.Subjects aged 50 years or older echocardiography had scanning infrarenal aorta consecutive 10 403 men and women.The subjects mean age 70.2 ± 10.7 years, 54.1%...