A5060375617- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Health Policy Implementation Science
- Glaucoma and retinal disorders
- Patient Satisfaction in Healthcare
- Delphi Technique in Research
- Clinical practice guidelines implementation
- Antibiotic Use and Resistance
- Primary Care and Health Outcomes
- Retinal Diseases and Treatments
- Dental Health and Care Utilization
- Statistical Methods in Clinical Trials
- Healthcare cost, quality, practices
- Retinal Imaging and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
- Prostate Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Dental Research and COVID-19
- Patient-Provider Communication in Healthcare
- Oral microbiology and periodontitis research
- Pelvic floor disorders treatments
- Appendicitis Diagnosis and Management
- Corneal surgery and disorders
- Mental Health and Patient Involvement
University of Aberdeen
2016-2025
Ohio Wesleyan University
1982-2024
University of Dundee
1997-2024
Primary Health Care
2021
University Medical Center Groningen
2017
University of Groningen
2017
University of Oxford
2014
Nuffield Orthopaedic Centre
2014
Hull Royal Infirmary
2014
Scottish Health Services
2014
Non-randomised studies of the effects interventions are critical to many areas healthcare evaluation, but their results may be biased. It is therefore important understand and appraise strengths weaknesses. We developed ROBINS-I ("Risk Of Bias In Studies - Interventions"), a new tool for evaluating risk bias in estimates comparative effectiveness (harm or benefit) from that did not use randomisation allocate units (individuals clusters individuals) comparison groups. The will particularly...
Objectives: A systematic review of the effectiveness and costs different guideline development, dissemination, implementation strategies wasundertaken. The resource implications these was estimated, a framework for deciding when it is efficient to develop introduce clinical guidelines developed.
In an interrupted time series (ITS) design, data are collected at multiple instances over before and after intervention to detect whether the has effect significantly greater than underlying secular trend. We critically reviewed methodological quality of ITS designs using studies included in two systematic reviews (a review mass media interventions a guideline dissemination implementation strategies).Quality criteria were developed, abstracted from each study. If primary study analyzed...
Uncertainty exists regarding the best management of patients with degenerative tears rotator cuff.To evaluate clinical effectiveness and cost-effectiveness arthroscopic open cuff repair in aged ≥ 50 years tendon tears.Two parallel-group randomised controlled trial.Nineteen teaching district general hospitals UK.Patients (n = 273) tears.Arthroscopic surgery repair, surgeons using their usual preferred method or repair. Follow-up was by telephone questionnaire at 2 8 weeks after postal 8, 12...
Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness safety remain uncertain.
A key step in the design of a RCT is estimation number participants needed study. The most common approach to specify target difference between treatments for primary outcome and then calculate required sample size. size chosen ensure that trial will have high probability (adequate statistical power) detecting should one exist. has many implications conduct interpretation Despite critical role RCT, way which it determined received little attention. In this article, we summarise...
Randomised controlled trials (RCTs) are considered the gold standard when evaluating causal effects of healthcare interventions. When RCTs cannot be used (e.g. ethically difficult), interrupted time series (ITS) design is a possible alternative. ITS one strongest quasi-experimental designs. The aim this methodological study was to describe how designs were being used, characteristics, and reporting in setting. We searched MEDLINE for reports published 2015 which had minimum two data points...
Objectives: To evaluate an intervention to reduce inappropriate use of key antibiotics with interrupted time series analysis. Methods: The is a policy for appropriate Alert Antibiotics (carbapenems, glycopeptides, amphotericin, ciprofloxacin, linezolid, piperacillin–tazobactam and third-generation cephalosporins) implemented through concurrent, patient-specific feedback by clinical pharmacists. Statistical significance effect size were calculated segmented regression analysis drug cost 2...