A5026660293- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Surgical Simulation and Training
- Orthopaedic implants and arthroplasty
- Nerve Injury and Rehabilitation
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Musculoskeletal pain and rehabilitation
- Elbow and Forearm Trauma Treatment
- Simulation-Based Education in Healthcare
- Musculoskeletal Disorders and Rehabilitation
- Innovations in Medical Education
- Trauma Management and Diagnosis
- Cardiovascular Syncope and Autonomic Disorders
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Tendon Structure and Treatment
- Sports injuries and prevention
- Health Systems, Economic Evaluations, Quality of Life
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Health and Medical Research Impacts
- Pain Management and Placebo Effect
University of Oxford
2016-2025
Nuffield Orthopaedic Centre
2016-2025
Oxford BioMedica (United Kingdom)
2019-2025
University of Birmingham
2025
John Radcliffe Hospital
2021-2025
Bristol Royal Infirmary
2024
National Institute for Health Research
2012-2022
Oxford Biomedical Research
2021-2022
NIHR Oxford Musculoskeletal Biomedical Research Centre
2014-2021
National Center for Environmental Health
2020
<h3>OBJECTIVE</h3> Muscles are essential components of our sensorimotor system that help maintain balance and perform a smooth gait, but it is unclear whether arthritic damage adversely affects muscle function. Quadriceps function in patients with knee osteoarthritis (OA) was investigated, these changes were associated impairment functional performance. <h3>METHODS</h3> strength, voluntary activation, proprioceptive acuity (joint position sense acuity) assessed 103 OA compared 25 healthy...
BackgroundArthroscopic sub-acromial decompression (decompressing the space by removing bone spurs and soft tissue arthroscopically) is a common surgery for subacromial shoulder pain, but its effectiveness uncertain. We did study to assess investigate mechanism surgical decompression.MethodsWe multicentre, randomised, pragmatic, parallel group, placebo-controlled, three-group trial at 32 hospitals in UK with 51 surgeons. Participants were patients who had pain least 3 months intact rotator...
We have studied cellular and vascular changes in different stages of full thickness tears the rotator cuff. examined biopsies from supraspinatus tendon 40 patients with chronic cuff who were undergoing surgery compared them four uninjured subscapularis tendons. Morphological immunocytochemical methods using monoclonal antibodies directed against leucocytes, macrophages, mast cells, proliferative markers used. Histological indicative repair inflammation most evident small sized increased...
Uncertainty exists regarding the best management of patients with degenerative tears rotator cuff.To evaluate clinical effectiveness and cost-effectiveness arthroscopic open cuff repair in aged ≥ 50 years tendon tears.Two parallel-group randomised controlled trial.Nineteen teaching district general hospitals UK.Patients (n = 273) tears.Arthroscopic surgery repair, surgeons using their usual preferred method or repair. Follow-up was by telephone questionnaire at 2 8 weeks after postal 8, 12...
The aim of this study was to investigate the effect laboratory-based simulator training on ability surgical trainees perform diagnostic arthroscopy knee. A total 20 junior orthopaedic were randomised receive either a fixed protocol arthroscopic bench-top knee or no additional training. Motion analysis used assess performance objectively. Each trainee then received traditional instruction and demonstrations in theatre before performing procedure under supervision blinded consultant trainer....
We developed a questionnaire to assess patient-reported outcome after surgery of the elbow from interviews with patients. Initially, 17 possible items five response options were included. A prospective study 104 patients (107 operations) was carried out analyse underlying factor structure, dimensionality, internal and test-retest reliability, construct validity responsiveness items. This compared Mayo Elbow performance score clinical scale, Disabilities Arm, Shoulder Hand questionnaire,...
Current musculoskeletal outcome tools are fragmented across different healthcare settings and conditions. Our objectives were to develop validate a single measure for use throughout the pathway patients with conditions: Arthritis Research UK Musculoskeletal Health Questionnaire (MSK-HQ).
The aim of this study was to investigate the occurrence tissue hypoxia and apoptosis at different stages tendinopathy tears rotator cuff. We studied from 24 patients with eight graded either impingement (mild, moderate severe) or cuff (partial, small, medium, large massive) three controls. Biopsies were analysed using immunohistochemical techniques, namely antibodies against HIF-1alpha (a transcription factor produced in a hypoxic environment), BNip3 regulated pro-apoptotic protein) TUNEL...
Background and purpose — The number of shoulder registries increases. We assessed international trends in use arthroplasty, described the current state procedure selection outcome presentation as documented national regional joint registries. Methods Published reports from 9 population-based arthroplasty (country/region: Norway, Sweden, New Zealand, Denmark, California, Australia, Emilia-Romagna, Germany, United Kingdom) were analyzed. Data extracted on age, sex, disease indication, type...
Definition Subacromial shoulder pain is commonly located to the top and lateral side of shoulder. It exaggerated by overhead activity can be associated with night pain. usually full passive range movement glenohumeral joint. The originates from subacromial space shoulder, an area made up rotator cuff tendons bursa. This separate main Pain this mainly caused tendinopathy, also referred as ‘shoulder impingement’. Impingement occurs between undersurface acromion (roof shoulder) tendons. These...
Objective This cohort study evaluates the unknown age-specific and gender-specific incidence of primary shoulder dislocations in UK. Setting UK care data from Clinical Practice Research Datalink (CPRD) were used to identify patients aged 16–70 years with a dislocation during 1995–2015. Coding was validated using CPRD general practitioner questionnaire service. Participants A 16 763 1995–2015 identified. Primary outcome measure Incidence rates per 100 000 person-years 95% CIs calculated....
The appropriate management for patients with a degenerative tear of the rotator cuff remains controversial, but operative treatment, particularly arthroscopic surgery, is increasingly being used. Our aim in this paper was to compare effectiveness open repair cuff.A total 273 were recruited randomised comparison trial (136 surgery and 137 surgery) from 19 teaching general hospitals United Kingdom. surgeons used their usual preferred method repair. Oxford Shoulder Score (OSS), two years...
Placebo or sham controls are the standard against which benefits and harms of many active interventions measured. Whilst components method their delivery have been shown to affect study outcomes, placebo rarely reported often not matched those comparator. This can influence how beneficial harmful intervention appears be. Without adequate descriptions controls, it is difficult interpret results about within placebo-controlled trials. To overcome this problem, we developed a checklist guide...
Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTK low CD48 + macrophages LYVE1 MRC1+ enriched for negative regulators of inflammation co-exist in frozen capsule tissues. Micro-cultures patient-derived cells integrin-mediated cell-matrix interactions between MERTK+ pro-resolving DKK3+...
To answer a national research priority by comparing the risk-benefit and costs associated with reverse total shoulder replacement (RTSR) anatomical (TSR) in patients having elective primary for osteoarthritis. Population based cohort study using data from National Joint Registry Hospital Episode Statistics England. Public hospitals publicly funded procedures at private England, 2012-20. Adults aged 60 years or older who underwent RTSR TSR osteoarthritis intact rotator cuff tendons. Patients...
Before proceeding to longer-term studies, we have studied the early clinical results of a new mobile-bearing total knee prosthesis in comparison with an established fixed-bearing device. Patients requiring bilateral replacement consented their operations under one anaesthetic using each prosthesis. They also agreed accept random choice (right or left) and remain ignorant as which side had implant. Outcomes were measured American Knee Society Score (AKSS), Oxford (OKS), determination range...
Background: Previous studies of task-specific skills have suggested that a loss technical performance occurs if the skill is not practiced for six-month period. The aims this study were to objectively demonstrate learning curve complex arthroscopic task (meniscal repair) by means motion analysis and determine impact repetition on retention skill. Methods: Nineteen orthopaedic residents with experience in routine knee arthroscopy but meniscal repair recruited into randomized study. During...
Abstract Objectives To provide accurate risk estimates of serious adverse events after elective shoulder replacement surgery for arthritis, including age and sex specific the lifetime revision surgery. Design Population based cohort study. Setting Hospital episode statistics NHS England, civil registration mortality data. Participants 58 054 replacements in 51 895 adults (aged ≥50 years) between April 1998 2017. Main outcome measures The surgery, calculated using an actuarial life table...