A5062634104- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Screening and Detection
- Redox biology and oxidative stress
- Smoking Behavior and Cessation
- Respiratory Support and Mechanisms
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Renal cell carcinoma treatment
- Pneumothorax, Barotrauma, Emphysema
- Sulfur Compounds in Biology
Leeds Teaching Hospitals NHS Trust
2016-2025
University of Leeds
2021-2025
St James's University Hospital
2015-2024
Peter MacCallum Cancer Centre
2024
Leeds General Infirmary
2008
Imperial College London
2005-2008
Royal Brompton Hospital
2000-2006
National Institutes of Health
2004
Northwick Park Hospital
2001-2002
Northwick Park Institute for Medical Research
2001
This guideline is based on a comprehensive review of the literature pulmonary nodules and expert opinion. Although management pathway for majority detected straightforward it sometimes more complex this helped by inclusion detailed specific recommendations 4 algorithms below. The Guideline Development Group (GDG) wanted to highlight new research evidence which has led significant changes in from previously published guidelines. These include use two malignancy prediction calculators (section...
Background Estimation of the risk malignancy in pulmonary nodules detected by CT is central clinical management. The use artificial intelligence (AI) offers an opportunity to improve prediction. Here we compare performance AI algorithm, lung cancer prediction convolutional neural network (LCP-CNN), with that Brock University model, recommended UK guidelines. Methods A dataset incidentally measuring 5–15 mm was collected retrospectively from three hospitals for a validation study. Ground...
Background Lung cancer outcomes in the UK are worse than many other developed nations. Symptom awareness campaigns aim to diagnose patients at an earlier stage improve outcomes. Methods An early diagnosis campaign for lung commenced Leeds, 2011 comprising public and primary-care facing components. Rates of community referral chest X-ray (TNM seventh edition) presentation were collected from 2008 2015. Linear trends assessed by χ 2 test trend proportions. Headline figures presented 3 years...
Low-dose computed tomography screening reduces lung cancer-specific mortality in high-risk individuals. Lung cancer risk factors overlap with comorbid diseases, highlighting the significance of frailty and comorbidities for (LCS). Here, we describe prevalence comorbidity those invited LCS evaluate their associations response to telephone assessment invitation subsequent uptake LCS. Analysis was based on intervention arm Yorkshire Screening Trial, where ever-smoked individuals aged 55-80 were...
Lung cancer is the world's leading cause of death. Low-dose computed tomography (LDCT) screening reduced lung mortality by 20% in US National Screening Trial. Here, we present Yorkshire Trial (YLST), which will address key questions relevance for implementation.
Background Chest X-ray (CXR) is the first-line investigation for lung cancer in many healthcare systems. An understanding of consequences false-negative CXRs on time to diagnosis, stage, and survival limited. Aim To determine sensitivity CXR compare stage at between those with that detected, or did not detect, cancer. Design setting Retrospective observational study using routinely collected data. Method All patients diagnosed Leeds Teaching Hospitals NHS Trust during 2008–2015 who had a...
Abstract Background The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study has compared the performance of models in UK. Methods We analysed current former smokers aged 40–80 years UK Biobank ( N = 217,199), EPIC-UK 30,813), Generations Study 25,777). quantified model calibration (ratio expected to observed cases, E / O ) discrimination (AUC)....
Screening with low-dose computed tomography (LDCT) reduces lung cancer mortality; however, the most effective strategy for optimising participation is unknown. Here we present data from Yorkshire Lung Trial, including response to invitation, screening eligibility and uptake of community-based LDCT screening.
The acute respiratory distress syndrome (ARDS) is an extreme form of lung injury characterised by disruption to the alveolar epithelium. KL-6 a mucin-like glycoprotein expressed on type II pneumocytes. Circulating levels have diagnostic and prognostic significance in number interstitial diseases, when elevated are thought indicate epithelial lining. In this study, authors sought determine whether plasma were patients with ARDS these associated aetiology, disease severity, outcome or...
Rationale: Patients with malignant pleural effusion experience breathlessness, which is treated by drainage and pleurodesis. Incomplete results in residual dyspnea pleurodesis failure. Intrapleural fibrinolytics lyse septations within fluid, improving drainage.Objectives: To assess the effects of intrapleural urokinase on success patients nondraining effusion.Methods: We conducted a prospective, double-blind, randomized trial. were randomly allocated 1:1 ratio to (100,000 IU, three doses,...
Stereotactic ablative radiotherapy (SABR) is a well-established treatment for medically inoperable peripheral stage I nonsmall cell lung cancer (NSCLC). Previous nonrandomised evidence supports SABR as an alternative to surgery, but high-quality randomised controlled trial (RCT) lacking. The SABRTooth study aimed establish whether UK phase III RCT was feasible.
Background Up to 50% of those attending for low-dose computed tomography screening lung cancer continue smoke and co-delivery smoking cessation services alongside may maximise clinical benefit. Here we present data from an opt-out co-located service delivered the Yorkshire Lung Screening Trial (YLST). Methods Eligible YLST participants were offered immediate consultation with a practitioner (SCP) at their visit ongoing support over subsequent weeks. Results Of 2150 eligible participants,...
<b>Background:</b> Acute lung injury (ALI) and its extreme manifestation the acute respiratory distress syndrome (ARDS) complicate a wide variety of serious medical surgical conditions. Thioredoxin is small ubiquitous thiol protein with redox/inflammation modulatory properties relevant to pathogenesis ALI. We therefore investigated whether thioredoxin raised extracellulary in patients ALI extent any increase dependent upon nature precipitating insult. <b>Methods:</b> Bronchoalveolar lavage...
Introduction Lung cancer outcomes in England are inferior to comparable countries. Patient or disease characteristics, healthcare-seeking behaviour, diagnostic pathways, and oncology service provision may contribute. We aimed quantify associations between geographic variations treatment survival of patients England. Methods retrieved detailed registration data analyse the variation 176,225 lung patients, diagnosed 2010-2014. used Kaplan-Meier analysis Cox proportional hazards regression...