A5025279015- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Advanced Radiotherapy Techniques
- Occupational and environmental lung diseases
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Dose and Imaging
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutropenia and Cancer Infections
- Cancer Immunotherapy and Biomarkers
- Soft tissue tumor case studies
- Nausea and vomiting management
- Esophageal Cancer Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Myasthenia Gravis and Thymoma
- Tracheal and airway disorders
- Prenatal Screening and Diagnostics
- Frailty in Older Adults
Leeds Teaching Hospitals NHS Trust
2013-2022
St James's University Hospital
2010-2020
National Health Service
2012-2019
The Christie NHS Foundation Trust
2011
North Yorkshire County Council
2009
European Organisation for Research and Treatment of Cancer
2007-2008
Ninewells Hospital
2007
West Lane Hospital
2005
Maidstone Hospital
2001
Medical Research Council
1991
We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had response to chemotherapy.
The effects of extra-pleural pneumonectomy (EPP) on survival and quality life in patients with malignant pleural mesothelioma have, to our knowledge, not been assessed a randomised trial. We aimed assess the clinical outcomes who were randomly assigned EPP or no context trimodal therapy Mesothelioma Radical Surgery (MARS) feasibility study.MARS was multicentre controlled trial 12 UK hospitals. Patients aged 18 years older had pathologically confirmed deemed fit enough undergo included. In...
A joint initiative by the British Thoracic Society and for Cardiothoracic Surgery in Great Britain Ireland was undertaken to update 2001 guidelines selection assessment of patients with lung cancer who can potentially be managed radical treatment.
BackgroundConcurrent chemoradiotherapy is the standard of care in limited-stage small-cell lung cancer, but optimal radiotherapy schedule and dose remains controversial. The aim this study was to establish a treatment regimen cancer.MethodsThe CONVERT trial an open-label, phase 3, randomised superiority trial. We enrolled adult patients (aged ≥18 years) who had cytologically or histologically confirmed Eastern Cooperative Oncology Group performance status 0–2, adequate pulmonary function....
Prophylactic cranial irradiation (PCI) in patients with extensive-disease small-cell lung cancer (ED-SCLC) leads to significantly fewer symptomatic brain metastases and improved survival. Detailed effects of PCI on health-related quality life (HRQOL) are reported here.Patients (age, 18 75 years; WHO < or = 2) ED-SCLC, any response chemotherapy, were randomly assigned either observation PCI. Health-related patient-reported symptoms secondary end points. The European Organisation for the...
PURPOSE Prophylactic irradiation to the chest wall after diagnostic or therapeutic procedures in patients with malignant pleural mesothelioma (MPM) has been a widespread practice across Europe, although efficacy of this treatment is uncertain. In study, we aimed determine prophylactic radiotherapy reducing incidence metastases (CWM) procedure MPM. METHODS After undergoing procedure, MPM were randomly assigned receive (within 42 days procedure) no radiotherapy. Open thoracotomies, needle...
Stereotactic ablative radiotherapy (SABR) is a well-established treatment for medically inoperable peripheral stage I nonsmall cell lung cancer (NSCLC). Previous nonrandomised evidence supports SABR as an alternative to surgery, but high-quality randomised controlled trial (RCT) lacking. The SABRTooth study aimed establish whether UK phase III RCT was feasible.
Stage I non-small cell lung cancer (NSCLC) is potentially curable, and surgery considered to be the standard of care for patients with good performance status minimal co-morbidity. However, a significant proportion stage NSCLC have poorer medical co-morbidity that make them at higher risk morbidity mortality from surgery. Stereotactic ablative radiotherapy (SABR), which uses modern radiotherapeutic techniques deliver large doses radiation, has shown superiority over conventional in terms...
Introduction Concurrent ONce-daily VErsus twice-daily RadioTherapy (CONVERT) is the only multicentre, international, randomised, phase III trial open in Europe and Canada looking at optimisation of chemoradiotherapy (RT) limited stage small cell lung cancer (LS-SCLC). Following on from Turrisi once-daily versus (BD) concurrent chemoradiotherapy, there a real need for new using modern conformal RT techniques investigating higher radiation dose. This has potential to define standard chemo-RT...
Histological diagnosis of malignant mesothelioma requires an invasive procedure such as CT-guided needle biopsy, thoracoscopy, video-assisted thorascopic surgery (VATs) or thoracotomy. These procedures encourage tumour cell seeding at the intervention site and patients can develop nodules within chest wall. In effort to prevent developing, it has been widespread practice across Europe irradiate sites postprocedure--a known prophylactic irradiation tracts (PIT). To date there not a suitably...
8504 Background: cCTRT is the standard of care for good PS LS-SCLC but there no international consensus on a regimen. BD RT has not been adopted widely due to concerns regarding logistics and toxicity. Our aim was compare overall survival toxicity with OD using modern conformal techniques given concurrently chemotherapy. Methods: Patients were randomised 1:1 receive 45Gy in 30 fractions over 3 weeks or 66Gy 33 6.5 starting day 22 cycle 1 chemotherapy (4 6 cycles Cisplatin 25mg/m2 days 1-3...
IntroductionWe used phase-3 CONVERT trial data to investigate the impact of fludeoxyglucose F 18 (18F-FDG) positron emission tomography (PET)/computed (CT) in SCLC.MethodsCONVERT randomized patients with limited-stage SCLC twice-daily (45 Gy 30 fractions) or once-daily (66 33 chemoradiotherapy. Patients were divided into two groups this unplanned analysis: those staged conventional imaging (contrast-enhanced thorax and abdomen CT brain without bone scintigraphy) 18F-FDG PET/CT...
ObjectivesMalignant pleural mesothelioma (MPM) is a rare and aggressive cancer with poor prognosis limited treatment options. This study assessed the characteristics, patterns, outcomes for patients diagnosed MPM in England.Materials methodsAs part of I-O Optimise, this retrospective cohort analyzed data recorded Cancer Analysis System England all adult newly between 2013 2017, follow-up to March 2018 or death, whichever occurred first. Overall survival (OS) was estimated using Kaplan–Meier...
Introduction Surgery is the standard of care for early-stage lung cancer, with stereotactic ablative body radiotherapy (SABR) a lower morbidity alternative patients limited physiological reserve. Comparisons outcomes between these treatment options are by competing comorbidities and differences in pre-treatment pathological information. This study aims to address issues assessing both overall cancer-specific survival presumed stage I cancer on an intention-to-treat basis. Methods...
Objectives To report characteristics, treatment and overall survival (OS) trends, by stage pathology, of patients diagnosed with non-small cell lung cancer (NSCLC) at Leeds Teaching Hospital NHS Trust in 2007–2018. Design Retrospective cohort study based on electronic medical records. Setting Large university hospital Leeds. Participants 3739 adult incident NSCLC from January 2007 to August 2017, followed up until March 2018. Main outcome measures Patient characteristics diagnosis, patterns...
Objective: To investigate chest wall pain in patients with peripheral early stage lung cancer treated stereotactic ablative radiotherapy (SABR), and to identify factors predictive of Common Terminology Criteria Adverse Events Grade 2 + pain. Methods: Patients who received 55 Gy five fractions were included. A structure was retrospectively defined on planning scans, dosimetry tumour-related recorded. Logistic regression performed ≥Grade Results: 182 187 tumours There 20 (10.9%) episodes...
4 Background: Prophylactic cranial irradiation (PCI) significantly reduces the risk of brain metastases (BM) and improves survival in patients with limited disease small cell lung cancer. Development BM is often accompanied by deterioration physical psychological functioning response to therapy poor. Patients extensive (ED SCLC) are at high for BM. This randomized study assesses PCI ED SCLC. Methods: (18–75 years; WHO=2) confirmed SCLC any 4–6 cycles chemotherapy, were receive (doses ranging...