A5066395614- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Cardiac Arrest and Resuscitation
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Protein Degradation and Inhibitors
- IL-33, ST2, and ILC Pathways
- Sepsis Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Ischemia and Reperfusion
- Air Quality and Health Impacts
- Respiratory and Cough-Related Research
- Hemoglobin structure and function
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tissue Engineering and Regenerative Medicine
- SARS-CoV-2 and COVID-19 Research
Imperial College London
2016-2025
Colorado School of Public Health
2024-2025
University of Colorado Anschutz Medical Campus
2024-2025
Native Health
2024-2025
Lung Institute
1995-2025
NIHR Imperial Biomedical Research Centre
2021-2022
British Airways (United Kingdom)
2021
Royal Brompton Hospital
1998-2019
Hunter Medical Research Institute
2019
Brigham and Women's Hospital
2019
Objective To ascertain the influence of albumin on antioxidant status in patients with acute lung injury. Design Prospective, randomized, placebo-controlled study. Setting Intensive care units, teaching hospitals. Patients Twenty meeting American European Consensus criteria for Interventions Ten received (25 g a 25% solution every 8 hrs total nine doses) and ten placebo (normal saline administered identical fashion volume). All supportive therapy appropriate Plasma samples were obtained...
Chronic inhalation of cigarette smoke is a prominent cause chronic obstructive pulmonary disease (COPD) and provides an important source exogenous oxidants. In addition, several inflammatory structural cells are endogenous oxidants in the lower airways COPD patients, even former smokers. This suggests that play key role pathogenesis COPD. oxidative stress counterbalanced by protective effects various antioxidant defenses airways. A large amount data from animal models patients with have...
1.Albumin is often administered intravenously to critically ill patients as a volume expander, combat hypoalbuminaemia, and decrease hyperbilirubinaemia. There is, however, an ongoing debate concerning the therapeutic benefit of former which expensive form treatment. 2.Albumin has several biological functions, in particular ligand binder. It also acts extracellular transition metal ion-binding radical-scavenging antioxidant. These functions are influenced by presence exposed thiol group (cys...
Objectives To assess activation of the inflammatory transcription factor NF-kappa B (NF-κB) in human idiopathic pulmonary arterial hypertension (PAH). Background Idiopathic PAH is a severe progressive disease characterized by vascular remodeling and excessive proliferation cells. Increasing evidence indicates that inflammation important pathophysiology. Methods NF-κB-p65 CD68, CD20 CD45 were measured immunohistochemistry confocal microscopy on lung specimens from patients with (n = 12)...
Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship levels regulatory responses in clinical experimental asthma. We show that cell-free are reduced bronchoalveolar lavage (BAL) supernatant of severe or mild–moderate asthma patients correlate with lower forced expiratory volume 1 s (FEV ). Conversely, iron-loaded cell numbers were increased BAL these FEV /forced vital capacity (FVC) ratio. The airway tissue expression...
Rationale: Mast cells (MCs) play a role in inflammation and both innate adaptive immunity, but their involvement severe asthma (SA) remains undefined. Objectives: We investigated the phenotypic characteristics of U-BIOPRED (Unbiased Biomarkers for Prediction Respiratory Diseases Outcomes) cohort by applying published MC activation signatures to sputum cell transcriptome. Methods: Eighty-four participants with SA, 20 mild/moderate (MMA), 16 healthy without were studied. calculated enrichment...
The extracellular matrix (ECM) is not just a three-dimensional scaffold that provides stable support for all cells in the lungs, but also an important component of chronic fibrotic airway, vascular, and interstitial diseases. It bioactive entity dynamically modulated during tissue homeostasis disease, controls structural immune cell functions drug responses, can release fragments have biological activity be used to monitor disease activity. There growing recognition importance considering...
The acute respiratory distress syndrome (ARDS) is an extreme form of lung injury characterised by disruption to the alveolar epithelium. KL-6 a mucin-like glycoprotein expressed on type II pneumocytes. Circulating levels have diagnostic and prognostic significance in number interstitial diseases, when elevated are thought indicate epithelial lining. In this study, authors sought determine whether plasma were patients with ARDS these associated aetiology, disease severity, outcome or...
We aimed to quantify concentrations of inducible heme oxygenase (HO)-1 in the lungs patients with acute respiratory distress syndrome (ARDS) and investigate its role as a source ferrous iron signaling agent for regulation. Control such processes by has implications onset, progression, resolution ARDS.Retrospective analysis archived samples.Adult intensive care unit postgraduate teaching hospital.Patients admitted adult who fulfilled American-European Consensus Conference criteria...
Nuclear factor kappa B (NF-kB)-mediated inflammatory gene expression and vascular endothelial cell proliferation/remodelling are implicated in the pathophysiology of fatal disease, pulmonary arterial hypertension (PAH). Bromodomain extra-terminal (BET) proteins essential for a subset NF-kB-induced genes. BET mimics including JQ1+ prevent binding BETs to acetylated histones down-regulate selected genes.The effects on proliferation primary human microvascular cells (HPMECs) from healthy...
Background —Acute right ventricular (RV) restrictive physiology after tetralogy of Fallot repair results in low cardiac output and a prolonged stay the intensive care unit (ICU). However, its mechanism remains uncertain. Methods Results —In first 24 hours (n=11 patients), serial prospective measurements were performed troponin T, indexes NO production (NO 2 − 3 combined as NOx), iron metabolism antioxidants. RV diastolic function was assessed by transthoracic Doppler echocardiography....