A5015443776- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Air Quality Monitoring and Forecasting
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Vehicle emissions and performance
- Noise Effects and Management
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Indoor Air Quality and Microbial Exposure
- Energy, Environment, and Transportation Policies
- Occupational exposure and asthma
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Medical and Biological Ozone Research
- Cardiovascular and exercise physiology
- Systemic Sclerosis and Related Diseases
- Pediatric health and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Delphi Technique in Research
- Fatty Acid Research and Health
Umeå University
2016-2025
Karolinska Institutet
2001-2023
University of Gothenburg
1990-2023
Karolinska University Hospital
2023
University of Manchester
2021
Manchester University
2021
Wythenshawe Hospital
2021
University Hospital of Umeå
1994-2020
King's College London
2019
University of Amsterdam
2019
Several epidemiologic studies have demonstrated a consistent association between levels of particulate matter (PM) in the ambient air with increases cardiovascular and respiratory mortality morbidity. Diesel exhaust (DE), addition to generating other pollutants, is major contributor PM pollution most places world. Although evidence strong, there are as yet no established biological mechanisms explain toxicity humans. To determine impact DE on human airways, we exposed 15 healthy volunteers...
The optimal treatment for mild asthma is uncertain. We assessed the effects of adding a long-acting inhaled beta-agonist, formoterol, to low doses an corticosteroid, budesonide, 1 yr in subjects with asthma, receiving no or only small dose corticosteroid. 698 corticosteroid free patients (Group A) were assigned twice daily 100 μ g budesonide plus 4.5 placebo. 1,272 corticosteroid-treated B) 200 formoterol. main outcome variables time first severe exacerbation and poorly controlled days. In...
Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure dilute diesel exhaust in patients stable coronary heart disease determine the direct effect of on myocardial, vascular, and fibrinolytic function.
Background— Although the mechanisms are unknown, it has been suggested that transient exposure to traffic-derived air pollution may be a trigger for acute myocardial infarction. The study aim was investigate effects of diesel exhaust inhalation on vascular and endothelial function in humans. Methods Results— In double-blind, randomized, cross-over study, 30 healthy men were exposed diluted (300 μg/m 3 particulate concentration) or 1 hour during intermittent exercise. Bilateral forearm blood...
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective improving understanding asthma disease mechanisms using systems biology approach. This cross-sectional assessment adults severe asthma, mild/moderate healthy controls from countries consisted analyses patient-reported outcomes, lung function, blood airway inflammatory measurements. Patients (nonsmokers, n=311; smokers/ex-smokers, n=110) had more...
The American Thoracic Society has previously published statements on what constitutes an adverse effect health of air pollution in 1985 and 2000. We set out to update broaden these past that focused primarily effects the respiratory system. Since then, many studies have documented other organ systems, such as cardiovascular central nervous systems. In addition, new biomarkers been developed applied studies. This current report seeks integrate latest science into a general framework for...
Exposure to combustion-derived air pollution is associated with an early (1-2 h) and sustained (24 rise in cardiovascular morbidity mortality. We have previously demonstrated that inhalation of diesel exhaust causes immediate (within 2 impairment vascular endothelial function humans.To investigate the systemic effects humans 24 hours after inhalation.Fifteen healthy men were exposed (particulate concentration, 300 microg/m(3)) or filtered for 1 hour a double-blind, randomized, crossover...
Although the mechanism is unclear, exposure to traffic-derived air pollution a trigger for acute myocardial infarction (MI). The aim of this study investigate effect diesel exhaust inhalation on platelet activation and thrombus formation in men.In double-blind randomized crossover study, 20 healthy volunteers were exposed dilute (350 microg/m(3)) filtered air. Thrombus formation, coagulation, activation, inflammatory markers measured at 2 6 h following exposure. was using Badimon ex vivo...
Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms.Using transcriptomic profiling of airway tissues, we sought to define the molecular phenotypes severe asthma.The transcriptome derived from bronchial biopsies epithelial brushings 107 subjects with moderate asthma were annotated gene set variation analysis using 42 signatures relevant asthma, inflammation, immune function. Topological data clinical histologic was performed derive clusters, nearest...
BackgroundAlthough several studies link high levels of IL-6 and soluble receptor (sIL-6R) to asthma severity decreased lung function, the role trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought explore association between epithelial IL-6TS pathway activation molecular clinical phenotypes patients.MethodsAn gene signature obtained from air-liquid interface cultures human bronchial cells stimulated with sIL-6R was used stratify transcriptomic data (Unbiased Biomarkers...
We have previously demonstrated that short-term exposure to diesel exhaust (DE) for 1 h induced a marked leukocytic infiltration in the airways of healthy human volunteers involving neutrophils, lymphocytes, and mast cells along with increases several inflammatory mediators. hypothesized leukocyte various responses by DE were mediated enhanced chemokine cytokine production resident airway tissue lumen. To investigate this, 15 exposed diluted air on two separate occasions each an chamber....
Particulate matter (PM) pollution adversely affects the airways, with asthmatic subjects thought to be especially sensitive. The authors hypothesised that exposure diesel exhaust (DE), a major source of PM, would induce airway neutrophilia in healthy subjects, and either these responses exaggerated mild allergic asthma, or DE exacerbate pre-existent airways. Healthy were exposed for 2 h ambient levels (particles 50% cut-off aerodynamic diameter 10 µm (PM ) 108 µg·m −3 lung function...
Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation injury only occurring higher concentrations. In the present study, authors examined whether similar occurred vivo , specifically antioxidants were upregulated following low-dose DE challenge investigated how these related development of airway different levels respiratory tract where particle dose varies markedly. A...
AimExposure to road traffic and air pollution may be a trigger of acute myocardial infarction, but the individual pollutants responsible for this effect have not been established. We assess role combustion-derived-nanoparticles in mediating adverse cardiovascular effects pollution.
In controlled human exposure studies, diesel engine exhaust inhalation impairs vascular function and enhances thrombus formation. The aim of the present study was to establish whether an particle trap could prevent these adverse cardiovascular effects in men.Nineteen healthy volunteers (mean age, 25±3 years) were exposed filtered air presence or absence a for 1 hour randomized, double-blind, 3-way crossover trial. Bilateral forearm blood flow plasma fibrinolytic factors assessed with venous...
Particulate matter (PM) pollution has been associated with negative health effects, including exacerbations of asthma following exposure to PM peaks. The aim the present study was investigate effects short-term diesel exhaust (DE) in asthmatics, by specifically addressing on airway hyperresponsiveness, lung function and inflammation. Fourteen nonsmoking, atopic asthmatics stable disease, continuous treatment inhaled corticosteroids, were included. All hyperresponsive methacholine. Each...