A5062472986- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thyroid Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Insect Resistance and Genetics
- Long-Term Effects of COVID-19
- RNA and protein synthesis mechanisms
- Neuroendocrine Tumor Research Advances
- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- COVID-19 and Mental Health
- Pancreatitis Pathology and Treatment
- Cardiac Fibrosis and Remodeling
- Tracheal and airway disorders
- Bacterial Genetics and Biotechnology
- Bone and Dental Protein Studies
- Tuberous Sclerosis Complex Research
- Food Allergy and Anaphylaxis Research
- Pleural and Pulmonary Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University Hospitals Coventry and Warwickshire NHS Trust
2016-2025
Inmunotek (Spain)
2016-2024
Universidad Ricardo Palma
2024
University of Zurich
2023
University Hospital Coventry
2016-2021
Coventry University
2017-2021
Biomedical Research Institute of Lleida
2011-2020
Hospital Universitari de Santa Maria
2020
Warwickshire Hospital
2016-2017
Royal Devon and Exeter Hospital
2015-2016
Background and purpose The COVID‐19 epidemic is affecting almost all individuals worldwide, patients with Alzheimer’s disease (AD) amnesic mild cognitive impairment (MCI) are particularly at risk due to their characteristics age. We analysed the impact of pandemic on these patients’ neuropsychiatric symptoms quality life after 5 weeks lockdown in Spain. Methods A total 40 a diagnosis MCI ( n = 20) or AD from Cognitive Stimulation Program Disorders Unit were evaluated. All had undergone...
Abstract Objective To evaluate whether a structured online supervised group physical and mental health rehabilitation programme can improve related quality of life compared with usual care in adults post-covid-19 condition (long covid). Design Pragmatic, multicentre, parallel group, superiority randomised controlled trial. Setting England Wales, home based interventions delivered remotely from single trial hub. Participants 585 (26-86 years) discharged NHS hospitals at least three months...
Summary We studied the cytological and biochemical properties of FtsA protein Streptococcus pneumoniae . is a widespread bacterial cell division that belongs to actin superfamily. In Escherichia coli Bacillus subtilis , localizes septal ring after FtsZ, but its exact role in septation not known. S. we found that, during exponential growth, nascent septa, at equatorial zones dividing cells, where an average 2200 molecules per are present. Likewise, FtsZ was localize with same pattern be...
Abstract: The alpha-1 antitrypsin (AAT) haplotype Pi*S, when inherited along with the Pi*Z to form a Pi*SZ genotype, can be associated pulmonary emphysema in regular smokers, and less frequently liver disease, panniculitis, systemic vasculitis small percentage of people, but this connection is well established. Since detection cases allow application preventive measures patients relatives congenital disorder, objective study was update prevalence SZ genotype achieve accurate estimates number...
Background There is an emerging understanding that coronavirus disease 2019 (COVID-19) associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its among patients hospitalised COVID-19 in the UK and describe factors outcome. Methods A structured survey PTM was conducted from September 2020 February 2021. UK-wide participation solicited via respiratory research networks. Identified had severe acute syndrome 2 (SARS-CoV-2) infection radiologically proven PTM. The...
Abstract Background Alpha-1 antitrypsin deficiency (AATD) is a rare disease that associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded the objective characterising individuals and investigating their natural history. Methods EARCO international, observational prospective study AATD, defined as AAT serum levels < 11 μM and/or proteinase inhibitor genotypes PI*ZZ, PI*SZ compound heterozygotes or...
With the aim of providing better clinical characterisation patients with α 1 -antitrypsin deficiency (AATD), we analysed data adult severe AATD enrolled in Spanish and Italian national registries. We assessed 745 subjects, 416 whom were registry 329 registry. 57.2% male 64.9% smokers or former a mean± sd age 49.9±13.8 years. Most (81.2%) index cases, mainly having PI*ZZ genotype (73.4%), diagnostic delay was 9.0±12.1 Patients chronic bronchitis younger, had preserved lung function lower...
.Currently, there is a remarkable lack of genetic epidemiological studies on alpha 1-antitrypsin (AAT) deficiency in about half the 193 countries World. This fact impedes establishment true prevalence pattern this deleterious hereditary disorder extensive regions human population. 2.The aim present study was to generate detailed maps frequency distribution two most frequent AAT alleles (i.e., PI*S and PI*Z) all areas 3.Available data provided by performed 94 worldwide used develop these...
Alpha-1 antitrypsin deficiency (AATD) is associated with an increased risk of pulmonary emphysema and liver disease. The growing interest in this Spain led to the development Spanish Registry Patients Antitrypsin Deficiency (REDAAT) 1993. At present, REDAAT a network more than 350 health care professionals database includes total 511 individuals. adult population included consists 469 individuals (91.8% total) their phenotype distribution is: 348 Pi*ZZ (74.2%), 100 Pi*SZ (21.3%) 21 carriers...
<b>Background:</b> Exogenous doses of 60 mg/kg α<sub>1</sub>-antitrypsin (AAT) every 7 days are recommended in patients with severe AAT deficiency. However, long term administration weekly is not well accepted by patients. Using pharmacokinetic simulations, we evaluated whether steady state minimum concentrations total can be maintained above the threshold 0.5 g/l longer intervals between doses. <b>Methods:</b> Several sets exogenous versus time simulations were studied using a non-linear...
Severe Alpha-1 Antitrypsin (AAT) deficiency is a hereditary condition caused by mutations in the SERPINA1 gene, which predisposes to lung emphysema and liver disease. It usually related PI*Z alleles, less frequent rare null (QO) alleles. Null-AAT alleles represent end of continuum variants associated with profound AAT extremely increased risk emphysema. A family severe was analyzed achieve genetic diagnosis. The complete exons introns gene were sequenced transcriptional analysis RT-PCR...
Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that leads to an increased risk of emphysema and liver disease. Despite extensive investigation, there remain unanswered questions concerning the natural history, pathophysiology, genetics prognosis lung disease in association with AATD. The European Clinical Research Collaboration (EARCO) designed bring together researchers from countries create standardised database for follow-up patients AATD.The EARCO Registry...
SERPINA1 is the gene for alpha-1 antitrypsin (AAT), an acute phase protein with anti-protease and immunoregulatory activities. Mutations in cause AAT deficiency predispose individuals to early-onset emphysema liver diseases. Expression of regulated by different promoters alternative splicing events among non-coding exons 1A, 1B 1C. We have developed three quantitative PCR (QT-PCR) assays (1A, 1C). These were applied analysis transcripts in: (1) 16 human tissues (2) peripheral blood...
The SERPINA1 gene is highly polymorphic, with more than 100 variants described in databases. encodes the alpha-1 antitrypsin (AAT) protein, and severe deficiency of AAT a major contributor to pulmonary emphysema liver diseases. In Spanish patients deficiency, we identified seven new involving amino acid substitutions different exons: PiSDonosti (S+Ser14Phe), PiTijarafe (Ile50Asn), PiSevilla (Ala58Asp), PiCadiz (Glu151Lys), PiTarragona (Phe227Cys), PiPuerto Real (Thr249Ala), PiValencia...
Abstract Background Although bronchiectasis has been recognised as a feature of some patients with Alpha1-Antitrypsin deficiency the prevalence and characteristics are not widely known. We wished to determine patient characteristics. The first cohort recruited EARCO (European Alpha1 Research Collaboration) International Registry data base by end 2021 was analysed for radiological evidence both emphysema well baseline demographic features. Results Of 505 PiZZ genotype entered into 418 (82.8%)...