Lars Fugger
A5027445785- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Diabetes and associated disorders
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- vaccines and immunoinformatics approaches
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Cell Adhesion Molecules Research
- Peripheral Neuropathies and Disorders
- Regulation of Appetite and Obesity
- Immune Response and Inflammation
- Genetic Associations and Epidemiology
- Circadian rhythm and melatonin
- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Reproductive System and Pregnancy
- HIV/AIDS Research and Interventions
Aarhus University Hospital
2012-2024
MRC Human Immunology Unit
2015-2024
University of Oxford
2015-2024
John Radcliffe Hospital
2015-2024
Medical Research Council
2009-2022
Aarhus University
2000-2022
MRC Weatherall Institute of Molecular Medicine
2008-2022
University of Copenhagen
1990-2018
Rigshospitalet
1990-2018
Danish National Research Foundation
2017-2018
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that time is ripe to complete 150-year-old effort identify all cell types human body. Human Cell Atlas Project an international collaborative aims define terms distinctive profiles (such as gene expression profiles) and connect this information with classical cellular descriptions location morphology). An open comprehensive reference map state cells...
Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401) CD4, but lacking endogenous II, we show that posttranslational glycosylation of type collagen (CII) influences level T cell tolerance to this candidate cartilage-specific autoantigen. In such mice, expression CII resulted tolerized murine CII. However, induction remained incomplete, preferentially...
T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck.Here we showed that catalytically active Lck was present in unstimulated naive cells thymocytes readily detectable these lymphoid organs.In up ∼40% total constitutively activated, part which also phosphorylated on C-terminal inhibitory site.Formation activated independent TCR coreceptors but required catalytic activity its maintenance relied monitoring...
Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.
Effective biomarkers for multiple sclerosis diagnosis, assessment of prognosis, and treatment responses, in particular those measurable blood, are largely lacking. We have investigated a broad set protein cerebrospinal fluid (CSF) plasma using highly sensitive proteomic immunoassay. Cases from two independent cohorts were compared with healthy controls patients other neurological diseases. identified replicated 10 proteins including IL-12B, CD5, MIP-1a, CXCL9 which had combined diagnostic...
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that most prevalent in Northern Europe. Although it known inherited risk for MS located within or close proximity to immune-related genes, unknown when, where how this genetic originated
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for dietary, physical and mental health present-day populations. Using a dataset more than 1,600 imputed ancient genomes
MHC class II (MHC-II) molecules play a central role in the selection of T cell repertoire, establishment and regulation adaptive immune response, autoimmune deviation. We have generated knockout mice lacking all four classical murine MHC-II genes (MHCII Δ / mice), via large (80-kilobase) deletion entire region that was engineered by homologous recombination Cre recombinase-mediated excision. These feature system perturbations like those Aα Aβ animals, notably dearth CD4 + lymphocytes thymus...