A5025660802- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Nicotinic Acetylcholine Receptors Study
- Hereditary Neurological Disorders
- Ion channel regulation and function
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Alzheimer's disease research and treatments
- Systemic Sclerosis and Related Diseases
- Genetic Neurodegenerative Diseases
- Autoimmune Bullous Skin Diseases
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
- Amyotrophic Lateral Sclerosis Research
- Cerebral Venous Sinus Thrombosis
- Receptor Mechanisms and Signaling
- Myasthenia Gravis and Thymoma
- Prion Diseases and Protein Misfolding
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Celiac Disease Research and Management
- Urticaria and Related Conditions
- IgG4-Related and Inflammatory Diseases
National and Kapodistrian University of Athens
2018-2025
Eginition Hospital
2018-2023
Stavros Niarchos Foundation
2020-2023
Fondazione IRCCS Istituto Neurologico Carlo Besta
2022
University of Thessaly
2022
Pasteur Hellenic Institute
1995-2021
Alexandra Hospital
2020
Aretaeio Hospital
2020
Athens Medical Center
2020
Red Cross Hospital
2013
IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition IL-17, Th-17 can also express IL-21, IL-22, IL-6 under Th-17-polarizing conditions (IL-6 transforming growth factor-β). this study we investigated IL-21 receptor (IL-21R) expression MS lesions by situ hybridization immunohistochemistry. We detected strongly IL-21(+) infiltrating predominantly acute...
<h3>Objective:</h3> To determine whether the activation of innate immune responses, which can be elicited by pathogenic and endogenous triggers, is associated with presence Epstein-Barr virus (EBV) infection in multiple sclerosis (MS) brain. <h3>Methods:</h3> White matter postmortem MS (n = 10) control tissue 11) was analyzed for expression proinflammatory cytokine interferon α (IFNα) immunohistochemistry EBV using highly sensitive method EBV-encoded RNA (EBER) situ hybridization....
Japanese encephalitis virus is a mosquito-borne flavivirus that causes approximately 10000 deaths annually in Asia. After brief viraemia, the enters central nervous system, but means of crossing blood-brain barrier uncertain. We used routine histological staining, immunohistology and electron microscopy to examine brain material from four fatal human cases, made comparisons with mouse model. In there was oedema, perivascular inflammation, haemorrhage, microglial nodules acellular necrotic...
Autoantibodies against aquaporin-4 (AQP4), a water channel in CNS astrocytes, are detected ∼50–80% of patients with neuromyelitis optica spectrum disorders (NMOsd), characterized by longitudinally extensive transverse myelitis (LETM) and/or optic neuritis. Although these autoantibodies present an invaluable biomarker for NMOsd and the differential diagnosis multiple sclerosis (MS), anti-AQP4-seronegative remains challenging. We hypothesized that seronegative might have aquaporin-1 (AQP1),...
<h3>Background and Objectives</h3> Autoantibodies against α3-subunit–containing nicotinic acetylcholine receptors (α3-nAChRs), usually measured by radioimmunoprecipitation assay (RIPA), are detected in patients with autoimmune autonomic ganglionopathy (AAG). However, low α3-nAChR antibody levels frequently other neurologic diseases questionable significance. Our objective was to develop a method for the selective detection of potentially pathogenic antibodies, seemingly present only AAG....
Background/Objectives: Paraneoplastic cerebellar degeneration (PCD) is an inflammatory autoimmune process caused by onconeural antibodies directed against Purkinje cells. In most cases, prognosis poor as disease progression leads to pancerebellar dysfunction and permanent neurological damage. Through this case report, we aim highlight the clinical presentation, diagnostic process, therapeutic implications associated with PCD secondary SCLC. Methods: Herein, present of a 57-year-old patient...
Introduction: Multiple Sclerosis (MS) is associated with a wide range of debilitating symptoms, and conventional therapies often fail to adequately address the disease’s multifaceted challenges. Cannabidiol (CBD) 13.0% + Delta9-tetrahydrocannabinol (THC) 9.0% (CBD13/THC9), vaporized cannabis-based medicinal product, presents novel therapeutic option for managing MS symptoms. Methods: This single-center longitudinal study followed 69 patients over six-month period. Participants were assessed...
Background: Paraneoplastic Neurological Syndromes (PNS) comprise a diverse group of disorders propagated by immune-mediated effects malignant tumors on neural tissue. Methods: A single-center longitudinal study was performed including consecutive adult patients treated at tertiary academic hospital between 2015 and 2023 diagnosed with PNS. PNS were ascertained using the 2004 revised 2021 PNS-Care diagnostic criteria. Results: Thirteen who fulfilled definite criteria included. neurological...