A5059645877- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Restless Legs Syndrome Research
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Epilepsy research and treatment
- Obstructive Sleep Apnea Research
- Autoimmune Neurological Disorders and Treatments
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Glycogen Storage Diseases and Myoclonus
- Acute Ischemic Stroke Management
- Neurological diseases and metabolism
- Cerebrovascular and genetic disorders
- Amyotrophic Lateral Sclerosis Research
- Attention Deficit Hyperactivity Disorder
- Cerebrospinal fluid and hydrocephalus
- Pharmacological Effects and Toxicity Studies
- Dysphagia Assessment and Management
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Neurological and metabolic disorders
National and Kapodistrian University of Athens
2016-2025
University General Hospital Attikon
2016-2025
Metropolitan Hospital
2020-2023
Evangelismos Hospital
2012-2023
University of West Attica
2020-2023
University of Thessaly
2020-2022
Fondazione IRCCS Istituto Neurologico Carlo Besta
2022
National Bank of Greece (Greece)
2021
Eginition Hospital
2006-2020
University of Cyprus
2020
The Stroop Test is a quick and frequently used measure in screening for brain damage, dysfunction of selective attention, cognitive flexibility. purpose the present study to provide normative data Trenerry's Neuropsychological Screening (SNST) sample 605 healthy Greek participants (age range: 18-84 years, education 6-18 years). Results revealed that age significantly contributed SNST scores, accounting significant proportion variance time needed complete color task interference Color-Word...
Dementia is generally considered as rapidly progressive [rapidly dementia (RPD)], in cases with overt cognitive impairment, established within months. Data about the relative frequency of underlying diseases RPD are few and extremely variable, depending on clinical setting. We examined causes RPD, a university tertiary referral center, Athens. A series consecutive patients presenting 3-year period was included. All received comprehensive clinical, imaging, laboratory evaluation. Of total 279...
Background: Conversely to other neurodegenerative diseases (i.e., Alzheimer's disease, AD), sleep in frontotemporal dementia (FTD) has not been studied adequately. Although some evidence exists that sleep-wake disturbances occur FTD, very little i
Background: The role of blood uric acid as a biomarker in symptomatic motor PD has been increasingly established the literature. Objective: Our present study assessed serum putative prodromal cohort [REM Sleep Behavior disorder (RBD) and Hyposmia] followed longitudinally. Methods: Longitudinal 5-year measurement data 39 RBD patients 26 Hyposmia with an abnormal DATSCAN imaging were downloaded from Parkinson’s Progression Markers Initiative database. These cohorts compared 423 de novo 196...
Background Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. Methods We assessed levels of total tau protein (τT), phosphorylated at threonine 181 (τP-181), β-amyloid1-42 (Aβ42) 34 patients with frontotemporal lobar degeneration (FTLD), 76 Alzheimer disease (AD) cases, 93 controls (CTRL). Double sandwich enzyme-linked immunosorbent assays (Innogenetics) were used for measurements. Results Total τ was significantly increased...
Although daytime sleepiness is commonly associated with obstructive sleep apnoea (OSA), the relationship between OSA severity and subjective has been documented elusive. This study aimed to identify clinical polysomnographic determinants of among patients suspected having OSA. A clinic-based sample 915 was interviewed a structured questionnaire underwent diagnostic overnight polysomnography. Subjective quantified by Epworth Sleepiness Scale (ESS). Excessive (defined as ESS score > 10)...
Epileptiform discharges (EDs) may be part of the internal arousing stimuli that affect quality sleep in patients with epilepsies. We studied association between EDs and phasic phenomena, its relevance to seizure control 19 juvenile myoclonic epilepsy (JME).We analyzed first cycle non-REM (rapid eye movement) 22 sleep-deprived electroencephalography (EEG) studies classified within cyclical alternating pattern (CAP) frame, grouping separately occurred at transition phases (B A B).Within CAP...
Objective To investigate the frequency and causes of early-onset dementia (EOD) in consecutive patients a highly specialized referral center, focusing on unusual cases, particularly with early and/or rapid onset, Athens, Greece. Methods Patients referred for diagnosis according to specific criteria during 3 years period. We examined distribution differences sex, education, severity, cognitive function, duration disease (from onset referral) between EOD (<65 y) late-onset (LOD) groups....
<h3>Background and Objectives</h3> Autoantibodies against α3-subunit–containing nicotinic acetylcholine receptors (α3-nAChRs), usually measured by radioimmunoprecipitation assay (RIPA), are detected in patients with autoimmune autonomic ganglionopathy (AAG). However, low α3-nAChR antibody levels frequently other neurologic diseases questionable significance. Our objective was to develop a method for the selective detection of potentially pathogenic antibodies, seemingly present only AAG....
Abstract Background The p.A53T variant in the SNCA gene was considered, until recently, to be only causing familial Parkinson's disease (PD) Greek population. We identified a novel heterozygous p.A30G (c.89 C>G) pathogenic five affected individuals of three families, leading autosomal dominant PD. This study aims further explore presence and phenotypic expression this PD Methods Restriction fragment length polymorphism (RFLPs) used for genotyping 664 cases. Detailed clinical information...
Background Patients with dementia face driving difficulties and, at some point, cease driving. Objective We sought to identify predictors of cessation among patients mild cognitive impairment (MCI) or Alzheimer's disease (AD). Methods enrolled in this longitudinal study MCI, AD (Clinical Dementia Rating < 2) and cognitively normal (NC) individuals. At baseline evaluation, participants underwent a neurological, neuropsychological simulator assessment. Re-evaluations after 48 84 months...
Sleep-disordered breathing (SDB) is common among acute stroke patients. We sought to investigate the prevalence, severity and type of SDB in consecutive Moreover, we aimed identify independent predictors setting potential associations between functional outcomes at three months. prospectively studied patients, who underwent overnight polysomnography within 72 h from symptom onset. Demographics, clinical imaging characteristics were documented. Daytime sleepiness preceding stroke, on...