A5059141503- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological disorders and treatments
- Hereditary Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Health, Environment, Cognitive Aging
- S100 Proteins and Annexins
- Trace Elements in Health
- Skin and Cellular Biology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Cerebrovascular and genetic disorders
- Polymer Surface Interaction Studies
- Multiple Sclerosis Research Studies
- RNA regulation and disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
Hospices Civils de Lyon
2014-2025
Centre de Recherche en Neurosciences de Lyon
2016-2025
Université Claude Bernard Lyon 1
2015-2025
Centre National de la Recherche Scientifique
2016-2025
Inserm
2015-2025
Laboratoire de Biomécanique et Mécanique des Chocs
2025
Centre Hospitalier Le Vinatier
2016-2024
HCL Technologies (India)
2012-2023
Centre d'Exploration et de Recherche Médicale par Emission de Positons
2022
Centre Hospitalier Universitaire de Grenoble
2016-2022
Immune checkpoint inhibitor-related encephalitis (ICI-encephalitis) is not well characterised and diagnostic prognostic biomarkers are lacking. We aimed to comprehensively characterise ICI-encephalitis identify outcome predictors.
Seed amplification assays (SAAs) demonstrate remarkable diagnostic performance in alpha-synucleinopathies. However, existing protocols lack accessibility routine laboratories, mainly due to the requirement for in-house production of recombinant alpha-synuclein (aSyn). This study proposes a cerebrospinal fluid (CSF) aSyn-SAA protocol using solely commercial reagents facilitate its clinical implementation. Routine care CSF samples from 126 patients, comprising 47 with Lewy body diseases (LBD)...
Tau proteins and amyloid-β (Aβ) peptides are the current recognized cerebrospinal fluid (CSF) biomarkers used as an aid in diagnosis of Alzheimer's disease (AD). However, there is no consensus on their clinical use due to non-qualified cut-off va
To describe CSF biomarker profiles in posterior cortical atrophy (PCA), which induces high-order visual deficits often associated with Alzheimer disease (AD) pathology, and relate these findings to clinical neuropsychological assessment.This prospective observational study included 22 patients PCA who underwent analysis of total tau (t-tau), phosphorylated on amino acid 181 (p-tau181), amyloid β (Aβ(42)). At group level, the were compared those typical AD other dementia (OD). Individually,...
Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob (CJD) are clinically distinguishable, atypical AD phenotypes may pose a diagnostic challenge. The major biological biomarker for identifying CJD, 14-3-3 protein in cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting rapid dementia presentation.To assess the relevance total CSF prion (t-PrP) levels differential diagnosis between CJD.A retrospective study an autopsy-confirmed cohort 82 patients was...
Abstract Introduction The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting results may differ, which can lead misunderstandings raises questions about commutability tests. Methods We obtained description (pre‐)analytical protocols sample reports 40 centers worldwide. A consensus approach allowed us propose harmonized comments...
The objective of this study was to analyze differences in biomarker outcomes before and after harmonization cerebrospinal fluid (CSF) collection tubes Alzheimer's disease (AD) diagnosis.We analyzed data from French memory centers that switched different CSF a common one. A total 1966 patients were included the study. concentrations β-amyloid 1-42 (Aβ42), tau, phosphorylated tau (p-tau181) measured each center using same commercial enzyme-linked immunoabsorbent assay (ELISA) kits. diagnostic...
To improve the etiological diagnosis of neurodegenerative dementias like Alzheimer's disease (AD) or frontotemporal dementia (FTD), we evaluated value individual and combined measurements following relevant cerebrospinal fluid (CSF) bio
The diagnosis of primary central nervous system lymphoma (PCNSL) can be challenging. PCNSL lesions are frequently located deep within the brain, and performing a cerebral biopsy is not always feasible. aim this study was to investigate diagnostic value CSF neopterin, marker neuroinflammation, in immunocompetent patients with suspected PCNSL.We retrospectively reviewed characteristics 124 brain tumor (n = 82) or an inflammatory CNS disorder 42) whom neopterin levels were assessed....
The combination of decreased amyloid β42 (Aβ42) and increased total tau proteins (T-Tau) phosphorylated (P-Tau) in cerebrospinal fluid (CSF) has recently been considered as a biological diagnostic criterion Alzheimer's disease (AD). Previous studies showed significant heterogeneity CSF Aβ42 levels to discriminate AD from non-AD patients. It was also suggested that the peptide β42/β40 ratio better performance than alone. objective present study investigate potential added value determining...
Redox-active metals are thought to be implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). To address this point, we measured the concentrations of 12 elements and, for first time, stable isotope compositions copper (redox-active) and zinc (redox-inactive) human cerebrospinal fluids 31 patients with ALS, 11 age-matched controls (CTRL), 14 Alzheimer disease. We show that metal weakly discriminate ALS from two other groups. then report isotopic similar three...
Core cerebrospinal fluid (CSF) biomarkers - Aβ42, Tau, and phosphorylated Tau (pTau) have been recently incorporated in the revised criteria for Alzheimer's disease (AD). However, their widespread clinical application lacks standardization. Pre-analytical sample handling storage play an important role reliable measurement of these across laboratories.In this study, we aim to surpass efforts from previous studies, by employing a multicenter approach assess impact less studied CSF...
We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected brain tissue. After neurologic symptoms appeared, transmissibility the disease by both routes was confirmed detection disease-associated prion protein in samples
Mammalian prions are proteinaceous pathogens responsible for a broad range of fatal neurodegenerative diseases in humans and animals. These can occur spontaneously, such as Creutzfeldt-Jakob disease (CJD) humans, or be acquired inherited. Prions primarily formed macromolecular assemblies the disease-associated prion protein PrPSc, misfolded isoform host-encoded PrPC. Within defined host-species, exist conformational variants strains. Based on both M/V polymorphism at codon 129 PrP...
Prions are proteinaceous pathogens responsible for subacute spongiform encephalopathies in animals and humans. The prions bovine encephalopathy (BSE) zoonotic agents, causing variant Creutzfeldt-Jakob disease (CJD) transfer of between species is limited by a barrier, which thought to reflect structural incompatibilities the host cellular prion protein (PrPC) infecting pathological PrP assemblies (PrPSc) constituting prion. A BSE strain variant, designated L-BSE atypical, supposedly...