A5058081634- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- S100 Proteins and Annexins
- Advanced Proteomics Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Bipolar Disorder and Treatment
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Machine Learning in Healthcare
- Neurological Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Biotin and Related Studies
- Neuroscience and Neuropharmacology Research
- Health, Environment, Cognitive Aging
- Extracellular vesicles in disease
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Prion Diseases and Protein Misfolding
- Neurosurgical Procedures and Complications
Copenhagen University Hospital
2015-2025
Rigshospitalet
2016-2025
University of Copenhagen
2016-2025
University of Gothenburg
2017-2024
UK Dementia Research Institute
2017
University College London
2017
Sahlgrenska University Hospital
2017
National Hospital for Neurology and Neurosurgery
2017
Hospital de Sant Pau
2017
Washington State University
2014
Abstract The boutons of the hippocampal mossy fibers stain particularly well with Timm's sulfide silver reaction for zinc and other metals. In present study anterograde degeneration was produced in rat by placing lesions fascia dentata, after which Timm checked at different postoperative intervals. No unequivocal changes were seen as early five hours operation. Barely discernible blanching affected parts fiber layer observed seven hours, a significant reduction stainability ten nearly...
Abstract Introduction Within‐person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild impairment 128), and AD dementia 110), a group cognitively unimpaired 154) also included. measured baseline follow‐up levels total tau (t‐tau), phosphorylated (p‐tau), YKL‐40, neurofilament light...
The aim of this study was to develop and evaluate a parallel reaction monitoring mass spectrometry (PRM-MS) assay consisting panel potential protein biomarkers in cerebrospinal fluid (CSF).Thirteen proteins were selected based on their association with neurodegenerative diseases involvement synaptic function, secretory vesicle or innate immune system. CSF samples digested two three peptides per quantified using stable isotope-labeled peptide standards.Coefficients variation generally below...
Neuroinflammation is recognized as part of the pathological progression Alzheimer's disease (AD), but molecular mechanisms are still not entirely clear. Systemically, physical exercise has shown to have a positive modulating effect on markers inflammation. It known if this general also takes place in central nervous system AD. The aim study was investigate 16 weeks moderate high-intensity selected biomarkers inflammation both systemically and CNS, patients with Plasma cerebrospinal fluid...
Abstract Background Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise Alzheimer’s disease (AD). For this purpose, we studied changes neuroprotective proteins proBDNF, BDNF, and humanin plasma NDEVs from patients with mild moderate AD participating randomized controlled trial (RCT) ADEX. Methods were quantified immunocaptured 95 ADEX participants, into control groups, collected at baseline 16 weeks. Exploratorily, also NDEV...
Alzheimer's disease (AD) is the most common cause of dementia, with no current cure. Consequently, alternative approaches focusing on early pathological events in specific neuronal populations, besides targeting well-studied amyloid beta (Aβ) accumulations and Tau tangles, are needed. In this study, we have investigated phenotypes to glutamatergic forebrain neurons mapped timeline their occurrence, by implementing familial sporadic human induced pluripotent stem cell models as well 5xFAD...
For clinical implementation of Alzheimer's disease (AD) blood-based biomarkers (BBMs), knowledge short-term variability, is crucial to ensure safe and correct biomarker interpretation, i.e., capture changes or treatment effects that lie beyond expected variability considered clinically relevant. In this study we investigated intra- inter-individual AD in the intended use population, memory clinic patients. a consecutive sample patients (AD n = 27, non-AD 20), blood samples were collected on...
<h3>Objective</h3> To use proteomic analysis of cerebrospinal fluid to discover novel proteins and peptides able differentiate between patients with stable mild cognitive impairment (MCI) those who will progress Alzheimer disease (AD). <h3>Design</h3> Baseline samples from MCI healthy controls were profiled using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. <h3>Setting</h3> Memory disorder clinic. <h3>Participants</h3> Patients (n = 113), whom 56 cognitively...
Diagnostic processes of Alzheimer's disease (AD) are evolving. Knowledge about disease-specific biomarkers is constantly increasing and larger volumes data being measured from patients. To gain additional benefits the collected data, a no
Previous studies have shown an association between disruption of the blood-brain-barrier (BBB) and dementias different etiologies. The protein concentration cerebrospinal fluid (CSF) can be used as indirect measurement for permeability BBB using CSF/plasma albumin quotient (Q-Alb) or total CSF protein.In current study, we wanted to investigate Q-Alb in etiologies possible confounding factors.A 510 patients healthy controls were included study. diagnosed with Alzheimer's disease (AD),...
Abstract Background Disturbances in the brain fluid balance can lead to life-threatening elevation intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, details underlying molecular mechanisms governing cerebrospinal (CSF) secretion are largely unresolved, thus preventing targeted and efficient pharmaceutical therapy of cerebral pathologies involving elevated ICP. Methods Experimental rats were employed for vivo determinations CSF rates, ICP, blood ex excised...
<i>Background:</i> An early and accurate diagnosis of Alzheimer’s disease (AD) is important in order to initiate symptomatic treatment with currently approved drugs will be even greater importance the advent disease-modifying compounds. <i>Methods:</i> Protein profiles human cerebrospinal fluid samples from patients AD (n = 85), frontotemporal dementia 20), healthy controls 32) were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass...
<b><i>Background:</i></b> Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies shown that amyloid beta (Aβ), one of pathological hallmarks AD, can be altered high levels physical activity. <b><i>Aim:</i></b> The objective this study was to elucidate 16 weeks moderate- high-intensity biomarkers special emphasis amyloidogenic pathway....
Abstract Bipolar disorder (BD) is a mental characterized by recurrent relapses of affective episodes, cognitive impairment, illness progression, and reduced life expectancy. Increased systemic oxidatively generated nucleoside damage have been found in some neurodegenerative disorders BD. As the first, this naturalistic prospective, longitudinal follow-up case-control study investigated cerebrospinal fluid (CSF) oxidative stress markers 8-oxo-7,8-dihydroguanosine (8-oxoGuo)...