Karim Bennys
A5067382402- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Nutrition and Health in Aging
- Frailty in Older Adults
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and related disorders
- GDF15 and Related Biomarkers
- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Sleep and Wakefulness Research
- Traumatic Brain Injury Research
- Genomics and Rare Diseases
- Acute Ischemic Stroke Management
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Restless Legs Syndrome Research
- Neurobiology of Language and Bilingualism
- Machine Learning in Healthcare
- Medication Adherence and Compliance
- Sleep and Work-Related Fatigue
- Macrophage Migration Inhibitory Factor
- Antioxidant Activity and Oxidative Stress
Université de Montpellier
2018-2025
Inserm
2007-2025
Centre Hospitalier Universitaire de Montpellier
2007-2024
Hôpital Gui de Chauliac
2001-2024
Institut des Maladies Neurodégénératives
2022
Centre National de la Recherche Scientifique
2018-2022
Centre Hospitalier Universitaire de Bordeaux
2022
CEA Paris-Saclay
2022
Université Paris-Saclay
2022
Université de Bordeaux
2022
Blood biomarkers for Alzheimer disease (AD) have consistently proven to be associated with CSF or PET and effectively discriminate AD from other neurodegenerative diseases. Our aim was test their utility in clinical practice, a multicentric unselected prospective cohort where patients presented large spectrum of cognitive deficits complaints. The MEMENTO enrolled 2,323 outpatients subjective complaint (SCC) mild impairment (MCI) consulting 26 French memory clinics. Participants had...
To assess the likely pathogenic/pathogenic (LP/P) variants rates in Mendelian dementia genes and moderate-to-strong risk factors patients with Alzheimer disease (AD). We included 700 a prospective study performed exome sequencing. A panel of 28 6 risk-factor was interpreted returned to patients. built framework for variant interpretation gradation assessed detection among early-onset AD (EOAD, age onset (AOO) ≤65 years, n = 608) depending on AOO pedigree structure late-onset (66 < 75, 92)....
Blood-based assays are expected to be integrated into clinical routines across various contexts, including Alzheimer's disease (AD). Vascular dementia (VaD), which is the second most common cause leading after AD, could also significantly benefit from this advancement. However, no informative fluid biomarker has been identified for VaD. Given disruption of iron homeostasis in both AD and VaD, study aims characterize potential iron-related hormone Hepcidin as a these two conditions. We will...
Summary: Event-related potentials (ERPs) have a large application in the evaluation of cognitive processes, particularly Alzheimer's disease (AD). The aim present study was to evaluate clinical relevance event-related evoked (N2 and P3 subcomponents) early diagnosis AD mild impairment (MCI). We prospectively studied 60 subjects. They all underwent following investigations: neurologic neuropsychological examination; functional evaluation, i.e., ERPs; cerebral imagery (morphologic functional)....
Abstract Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder with β-amyloid pathology as key underlying process. The relevance of cerebrospinal fluid (CSF) and brain imaging biomarkers validated in clinical practice for early diagnosis. Yet, their cost perceived invasiveness are limitation large-scale implementation. Based on positive amyloid profiles, blood-based should allow to detect people at risk AD monitor patients under therapeutics strategies. Thanks the...
<h2>Summary</h2><h3>Background</h3> It is unknown whether multidomain interventions, which might preserve late-life cognition, affect Alzheimer's disease pathology. Previous studies measured cerebrospinal fluid and imaging biomarkers in small subsamples of trial participants. Newly developed assays enable the measurement blood-based larger samples. We aimed to assess plasma tau phosphorylated at threonine 181 (p-tau181) was able detect or predict 3-year intervention effects. <h3>Methods</h3>...
Abstract Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and decline older adults are still limited. 504 (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) classified as normal cognition (NC) or mild impairment (MCI). Cognitive functions measured mini mental state examination (MMSE) composite score (CCS) over a 4-year period....
Abstract Background Vitality is conceptually considered as the underlying capacity influencing other intrinsic (IC) domains and being related to nutrition, physiological reserve biological ageing. However, there no consensus on its operationalisation. Objective To investigate structure magnitude of association vitality with IC functional difficulties using three operational definitions vitality. Methods We included 1,389 older adults from Multidomain Alzheimer Preventive Trial data Mini...
This study was designed to evaluate the predictive value of event-related potential (ERP; N2 and P3b) in patients with mild cognitive impairment (MCI). Seventy-one MCI were selected compared 31 healthy control subjects. They benefited from an initial assessment that included a neuropsychological evaluation ERP. We followed them up for 1 year, during their last visit, they again ERP tests. At end study, 2 subgroups differentiated according clinical evolution baseline follow-up: 41 progressors...
Abstract Background Cognition is closely associated with physical function. Although high brain amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are cognitive gait speed decline, relationships of combined plasma Aβ NfL profiles functions in older adults remain unknown. The research aim this study was to investigate the prospective associations adults. Methods Participants ( n = 452, aged 76 ± 5 years) who had both data collected from Multidomain Alzheimer’s Preventive Trial...
To assess the role of biomarkers Alzheimer disease (AD), neurodegeneration, and small vessel (SVD) as mediators in association between diabetes mellitus cognition. The study sample was derived from MEMENTO, a cohort French adults recruited memory clinics screened for either isolated subjective cognitive complaints or mild impairment. Diabetes defined based on blood glucose assessment, use antidiabetic agent, self-report. We used structural equation modeling to whether latent variables AD...
Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated. We explored the cross-sectional associations PA concentrations neurofilament light chain (NFL) and beta amyloid (Aβ)42/40. further examined whether interaction between these was longitudinally related to cognition. Four-hundred sixty-five nondemented older adults engaged in an interventional study who had a concomitant assessment levels...
Neuroimaging studies have described the brain alterations in primary progressive aphasia (PPA) variants (semantic, logopenic, nonfluent/agrammatic). However, few combined T1, FDG-PET and diffusion MRI techniques to study atrophy, hypometabolism tract across three PPA main variants. We therefore explored a large early-stage cohort of semantic, logopenic nonfluent/agrammatic (N = 86) 23 matched healthy controls with anatomical (cortical thickness), FDG PET (metabolism) (white matter tracts...
Objective: To identify self-reported sleep-wake disturbances that increase the risk of cognitive decline over 1-year follow-up in frail participants. Background: Risk factors for impairment need to be better identified especially at earliest stages pathogenesis. Sleep-wake may critical consider and were thus being assessed this at-risk population decline. Methods: Frail elderly participants aged ≥70 years selected from a subsample Multi-domain Alzheimer Preventive Trial (MAPT) sleep...
Abstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA proteomic risk indicators for dementia. Here we report that plasma concentrations predict cognitive decline the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n 452). Cognitive ability was evaluated using a composite score (CCS) assessed four domains: memory, language, executive function, orientation....
Importance Blood phosphorylated tau 217 (p-tau217) showed good performance in predicting brain amyloidosis. However, the importance of detailed cognitive phenotyping patients without dementia when interpreting p-tau217 results remains unclear. Objective To assess whether accuracy, negative predictive value (NPV), and positive (PPV) amyloidosis using varies across clinical presentations dementia. Design, Setting, Participants The study design included 2 observational, prospective cohort...
Identifying individuals at risk for dementia and Alzheimer's disease (AD) in the general population (GP) is increasingly essential due to new diagnostic criteria opportunities effective interventions. Plasma-based biomarkers (pBB) offer a promising approach detecting positive amyloid profile. However, their effectiveness predicting clinical AD GP level remains largely unexplored. To assess of using pBB most up-to-date proteomic techniques. Case-cohort study randomly selected from prospective...
Abstract Background Alzheimer disease (AD) is a common complex disorder with high genetic component. Loss-of-function (LoF) SORL1 variants are one of the strongest AD risk factors. Estimating their age-related penetrance essential before putative use for counseling or preventive trials. However, relative rarity and co-occurrence main factor, APOE -ε4, make such estimations difficult. Methods We proposed to estimate -LoF through survival framework by estimating conditional instantaneous...
Objective To determine the relationships between self-reported sleep profile and cortical amyloid load in elderly subjects without dementia. Methods This cross-sectional study included 143 community-dwelling participants aged ≥70 years (median: 73 [70-85]; 87 females) with spontaneous memory complaints but dementia-free. Sociodemographic characteristics, health status, neuropsychological tests, 18F-florbetapir (amyloid) PET data were collected. The clinical interview evaluated nighttime...