A5007215577- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Stroke Rehabilitation and Recovery
- Vitamin D Research Studies
- Emergency and Acute Care Studies
- Chronic Disease Management Strategies
- Geriatric Care and Nursing Homes
- Functional Brain Connectivity Studies
- Older Adults Driving Studies
- Nutrition and Health in Aging
- Art Therapy and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Health, Medicine and Society
- Stress Responses and Cortisol
- Hip and Femur Fractures
- Music Therapy and Health
- Injury Epidemiology and Prevention
- Bone health and osteoporosis research
- Intensive Care Unit Cognitive Disorders
- Diabetic Foot Ulcer Assessment and Management
Jewish General Hospital
2016-2025
Institut Universitaire de Gériatrie de Montréal
2020-2025
Université de Montréal
2020-2025
McGill University
2016-2025
Nanyang Technological University
2018-2024
Hôpital Broca
2021
University Health Network
2015-2020
McGill University Health Centre
2015-2020
Université d'Angers
2008-2018
Centre Hospitalier Universitaire d'Angers
2009-2017
To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease.
Little information exists about the involvement of attention in control gait rhythmicity. Variability both stride time and length is closely related to rhythmic stepping mechanism. We sought 1) determine whether backward counting while walking could provoke significant changes mean values coefficients variation velocity, among healthy young adults; 2) establish change stride-to-stride variability be dual-task velocity change, attention, or both.Mean were recorded using Physilog-system, at a...
Abstract: Gait disorders are more prevalent in dementia than normal aging and related to the severity of cognitive decline. Dementia-related gait changes (DRGC) mainly include decrease walking speed provoked by a stride length an increase support phase. More recently, dual-task were found Alzheimer's disease (AD) non-Alzheimer dementia, even at early stage. An stride-to-stride variability while usual dual-tasking has been shown be specific sensitive any change mean value subjects with...
Conflicting results have been reported regarding the relationship between stride time variability (STV) and walking speed. While some studies failed to establish any relationship, others either a linear or non-linear relationship. We therefore sought determine extent which decrease in self-selected speed influenced STV among healthy young adults.The mean value, standard deviation coefficient of variation time, as well value velocity were recorded while steady-state using GAITRite system 29...
Background. Gait disorders, a highly prevalent condition in older adults, are associated with several adverse health consequences. analysis allows qualitative and quantitative assessments of gait that improves the understanding mechanisms disorders choice interventions. This manuscript aims 1) to give consensus guidance for clinical spatiotemporal based on recorded footfalls adults aged 65 years over, 2) provide reference values parameters healthy free cognitive impairment multi-morbidities....
To determine whether dual task-related changes in walking speed were associated with recurrent falls frail older adults.Twelve-month prospective cohort study.Thirteen senior housing facilities.Two hundred thirteen subjects (mean age 84.4+/-5.5).Usual and dual-tasking speeds (m/s) calculated on a 10-m straight walkway at baseline. Information incident during the follow-up year was collected monthly, participants divided into three groups based occurrence of (0, 1, >or=2). Recurrent defined as...
A new paradigm is emerging in which mobility and cognitive impairments, previously studied, diagnosed, managed separately older adults, are fact regulated by shared brain resources. Deterioration these mechanisms normal aging neurodegeneration increases the risk of developing dementia, falls, fractures. This requires an integrated approach to measuring both domains. We aim identify a complementary battery existing tests cognition community-dwelling adults that enable assessment...
Sleep related breathing disorders (SRBD) are risk factors for cognitive dysfunction in middle-aged subjects, but this association has not been observed the elderly. We assess impact of SRBD on performance a large cohort healthy elderly subjects. Cross-sectional study examining between subjective memory test, neuropsychological battery testing and Community-based sample home research clinical settings. 827 58.5% women, aged 68 y at entry, participated study. All were free previously diagnosed...
Background.Aging is often associated with modifications of gait. Recent studies have revealed a strong relationship between gait and executive functions in healthy pathological aging. We hypothesized that modification due to aging may be related changes frontal lobe function.
The interpretation of the increase in stride-to-stride variability stride time (STV) regarding evolution cognitive deficits across dementia spectrum is matter debate.
Background and purpose The differences in gait abnormalities from the earliest to later stages of dementia different subtypes have not been fully examined. This study aims compare spatiotemporal parameters cognitively healthy individuals, patients with amnestic mild cognitive impairment ( MCI ) non‐amnestic , moderate Alzheimer's disease AD non‐Alzheimer's (non‐ ). Methods Based on a cross‐sectional design, 1719 participants (77.4 ± 7.3 years, 53.9% female) were recruited cohorts seven...
Few studies looked at the association between gait variability and executive subdomains (ESD). The aim of this study was to examine ESD (i.e., information updating monitoring) stride time among healthy older adults. Seventy-eight adults (mean age 69.9 ± 0.9 years, 59% women) were divided into 3 groups according (STV) tertiles while steady state walking. Coefficient variation used as a marker STV. Scores on cognitive tests evaluating monitoring (Digit Span test), mental shifting (Trail Making...
Abstract Early therapeutic interventions are essential to prevent Alzheimer Disease (AD). The association of several inflammation-related genetic markers with AD and the early activation pro-inflammatory pathways in suggest inflammation as a plausible target. Inflammatory Caspase-1 has significant impact on AD-like pathophysiology inhibitor, VX-765, reverses cognitive deficits mouse models. Here, one-month pre-symptomatic treatment Swedish/Indiana mutant amyloid precursor protein (APP Sw/Ind...
<i>Background:</i> Changes in gait patterns due to a simultaneously performed cognitive task have been reported previously and associated with an increased falling risk among older adults. Little is known whether the type of while walking important concerning possible interference fall-prone individuals. <i>Objective:</i> To quantify compare effects two different tasks on transitionally frail <i>Measurements:</i> Gait was tested 30 adults (mean age 82.6 ±...
Executive dysfunction contributes to gait changes, but the precise mechanisms are still poorly understood. Dual-task-related changes depend in part on capacity appropriately allocate attention between tasks performed simultaneously and mainly related executive deficits. This study aimed describe impact of dysexecutive function stability subjects with dementia using dual tasking.Mean values coefficients variation stride time while only walking backward counting (dual tasking) were measured...