A5020682355- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Nutrition and Health in Aging
- Physical Activity and Health
- ATP Synthase and ATPases Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience of respiration and sleep
- Cardiovascular and exercise physiology
- Dementia and Cognitive Impairment Research
- Adipose Tissue and Metabolism
- Cardiovascular and Diving-Related Complications
- Mitochondrial Function and Pathology
- Blood Pressure and Hypertension Studies
- Blood Coagulation and Thrombosis Mechanisms
- Frailty in Older Adults
- Adipokines, Inflammation, and Metabolic Diseases
- Vagus Nerve Stimulation Research
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Obesity, Physical Activity, Diet
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Health and Lifestyle Studies
- Health disparities and outcomes
Inserm
2023-2025
Université Toulouse III - Paul Sabatier
2023-2025
Centre Hospitalier Universitaire de Toulouse
2021-2025
Institute of Aging
2025
Université de Toulouse
2023-2025
Médipole Garonne
2021-2024
Weatherford College
2023
Maastricht University
2023
University Medical Center
2023
Institut des Maladies Métaboliques et Cardiovasculaires
2023
Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated. We explored the cross-sectional associations PA concentrations neurofilament light chain (NFL) and beta amyloid (Aβ)42/40. further examined whether interaction between these was longitudinally related to cognition. Four-hundred sixty-five nondemented older adults engaged in an interventional study who had a concomitant assessment levels...
Abstract Aging is characterized by several major changes, including altered body composition, which associated with numerous negative clinical consequences such as sarcopenia, osteoporosis, and frailty. The study to evaluate composition parameters depending on age sex in a population ranging from the young adult very old, identify break points association between age. In this cross-sectional study, we included enrolment of French INSPIRE-T prospective cohort, accounting for 915 subjects (62%...
Abstract Background The adiponectin is one of the rare adipokines down-regulated with obesity and protects against obesity-related disorders. Similarly, apolipoprotein M (apoM) expressed in adipocytes its expression adipose tissue associated metabolic health. We compared circulating apoM regarding their relationship parameters insulin sensitivity examined gene patterns tissue. Methods Circulating were 169 men overweight a cross-sectional study, 13 patients during surgery-induced slimming...
No study has tried to distinguish subjects that become frail due diseases (frailty related diseases) or in the absence of specific medical events; this latter case, it is possible aging process would act as main frailty driver (age-related frailty).
Abstract Background The way physical activity (PA) and sedentary behaviour (SB) independently interactively modify the age‐related decline in capacity remains poorly understood. This cross‐sectional study investigated independent interactive associations of PA SB with function performance throughout adult life course. Methods Data from 499 community‐dwelling adults (63% female) aged 20–92 years, involved INSPIRE Human Translational Cohort, were used this study. Daily time spent on...
Abstract Aging varies across individuals, highlighting the need for better markers of functional decline. This study investigates hypothesis that T cell energy metabolism is correlated with health in older adults. We used flow cytometry-based profiling to examine metabolism, focusing on mitochondrial OXPHOS activity (MitoDep, expressed as percentage), peripheral CD4 and CD8 subsets from 187 participants aged 70-89 years (mean age 78.7 [SD 5.3], 57.7% [n = 108] women) within Inspire-T cohort....
Physical exercise is well known for its benefits on brain health. However, the mechanisms through which these occur remain discussed, especially in context of cognitive conditions such as Alzheimer's disease. The present short review summarizes findings interventional studies that examined effects training specific and non-specific biomarkers Controlled intervention published English language were selected if they assessed a physical at least 2 weeks middle-aged or older adults one following...
Abstract INTRODUCTION Although recent studies have suggested a positive association between plasma neurofilament light chain (NfL) and depressive symptoms, the moderating effect of cognitive performance on this relationship remains unclear. The aim study was to investigate NfL symptoms in population community‐dwelling older adults determine whether status could modify relationship. METHODS This is secondary analysis Multidomain Alzheimer Preventive Trial (MAPT), including 512 individuals...
While obstructive sleep apnea (OSA) increases chemoreflex, leading to an autonomic dysfunction in the long term, no studies have yet assessed potential benefit of exercise on cardiac activity these patients. The aim this study was evaluate improvement function (CAF) measured through heart rate variability (HRV) after a 9-month physical program patients with OSA. Seventy-four moderate OSA, aged 40-80 years, were randomly assigned group (n = 36, 3 × 1 h/wk) or control 38) during 9 months....
Late-life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated putative mediating aspect of growth differentiation factor 15 (GDF-15), a stress signalling protein in aging, exercise control, on association between PA late-life-associated loss.One thousand eighty-three healthy adults (63.8% women) aged 70 years over who participated Multidomain...
Age-related changes in brain structure may constitute the starting point for cerebral function alteration. Physical activity (PA) demonstrated favorable associations with total volume, but its relationship cortical thickness (CT) remains unclear. We investigated cross-sectional between PA level and CT community-dwelling people aged 70 years older.A of 403 older adults 74.8 ± 4.0 (mean SD) who underwent a baseline magnetic resonance imaging examination had data on confounders were included....
Mitochondrial dysfunction is associated with the development of type 2 diabetes mellitus (T2DM). It thus clinical relevance to identify plasma biomarkers mitochondrial risk T2DM. ATPase inhibitory factor 1 (IF1) endogenously inhibits ATP synthase activity. Here, we analyzed association IF1 level markers glucose homeostasis and conversion new-onset (NOD) in individuals prediabetes.In IT-DIAB prospective study, baseline was measured 307 participants prediabetes. The primary outcome incidence...
Background: Work may contribute significantly to daily physical activity (PA) and sedentary behaviour (SB). Physical inactivity SB at work might be two major risk factors for premature morbidity. Therefore, the aim of this research was describe self-reported past PA during leisure time within PROOF cohort subjects, determine consequences on late health these now retired workers. Material methods: The study used prospectively allow assessment predictive value among a healthy French...
Although regular physical activity improves obstructive sleep apnea (OSA) in the general population, this finding has not been assessed postmyocardial infarction (MI) patients a rehabilitation setting (coronary artery disease, CAD). We aimed to determine whether cardiac may benefit post-MI terms of OSA disease and associated autonomic nervous system (ANS) activity.Consecutive participating ambulatory program St-Etienne University Hospital were included study. The apnea-hypopnea index...
Although recent trials have shown promising benefits of exercise on obstructive sleep apnea (OSA) severity, the long-term effect these interventions remains unknown. The aim this study was to assess a 9-month community physical activity program OSA severity one year later in free-living conditions. patients, previously included randomized controlled trial (EXESAS study) evaluating effects supervised were invited participate an extra one-year observational study. Twenty-eight patients...
Abstract Physical activity (PA) has been shown to moderate the negative effects of obesity on pro-inflammatory cytokines but its relationship with adipokine progranulin (PGRN) remains poorly investigated. This study aimed examine cross-sectional main and interactive associations body mass index (BMI) PA level circulating PGRN in older adults. Five-hundred twelve participants aged 70 years involved Multidomain Alzheimer Preventive Trial (MAPT) who underwent plasma measurements (ng/mL) were...