A5052525360- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Diabetes and associated disorders
- Diet and metabolism studies
- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Gut microbiota and health
- Eating Disorders and Behaviors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Surgical Simulation and Training
- Chronic Disease Management Strategies
- Nutritional Studies and Diet
- Genetics and Neurodevelopmental Disorders
Aix-Marseille Université
2016-2025
Inserm
2016-2025
Hôpital de la Conception
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2006-2024
Nutrition, Obésité et Risque Thrombotique
2006-2023
Weatherford College
2023
Institut des Maladies Métaboliques et Cardiovasculaires
2023
Centre Hospitalier Universitaire de Toulouse
2023
Université Toulouse III - Paul Sabatier
2023
Obesity is associated with increased health risk and has been alterations in bacterial gut microbiota, mainly a reduction Bacteroidetes, but few data exist at the genus species level. It reported that Lactobacillus Bifidobacterium representatives may have critical role weight regulation as an anti-obesity effect experimental models humans, or growth-promoter agriculture depending on strains. To confirm test whether found human are obesity lean status, we analyzed stools of 68 obese 47...
Genus and species level analysis is the best way to characterize alterations in human gut microbiota that are associated with obesity, because clustering of obese lean microbiotas increases taxonomic depth analysis. Bifidobacterium genus members have been a status, whereas different Lactobacillus both an status. We analyzed fecal concentrations Bacteroidetes, Firmicutes, Methanobrevibacter smithii, Lactobacillus, five other previously linked or populations, Escherichia coli animalis 263...
The clinical expression of maturity-onset diabetes the young (MODY)-3 is highly variable. This may be due to environmental and/or genetic factors, including molecular characteristics hepatocyte nuclear factor 1-alpha (HNF1A) gene mutation.We analyzed mutations identified in 356 unrelated MODY3 patients, 118 novel mutations, and searched for correlations between genotype age at diagnosis diabetes.Missense prevailed dimerization DNA-binding domains (74%), while truncating were predominant...
Whereas postprandial hyperlipidemia is a well-described feature of insulin-resistant states and type 2 diabetes, no previous studies have examined intestinal lipoprotein production rates (PRs) in relation to hyperinsulinemia or insulin resistance humans.Apolipoprotein B-48 (apoB-48)-containing metabolism was the steady-state fed condition with 15-hour primed constant infusion [D3]-l-leucine 14 nondiabetic men broad range body mass index (BMI) sensitivity. To examine relationship between...
Background— Hepatic lipoprotein production has been shown previously to be regulated by free fatty acid (FFA) flux the liver, whereas intestinal is stimulated mainly ingested fat absorbed from lumen. Emerging evidence indicates that increased in insulin resistance and type 2 diabetes mellitus, conditions are associated with levels of circulating FFAs. Here we investigated whether short-term elevation plasma FFAs stimulates apolipoprotein (apo) B-48– hepatic apoB-100–containing...
The diagnosis of maturity-onset diabetes the young type 3 (MODY3), associated with HNF1A molecular abnormalities, is often missed.The objective study was to describe phenotypes a large series MODY3 patients and reassess parameters that may improve its diagnosis.This retrospective multicenter included 487 unrelated referred because suspicion MODY3. Genetic analysis identified 196 283 non-MODY3 cases. Criteria were assessed by multivariate analysis. capacity model predict area under...
Dominant variants in
BACKGROUND: Patients with homozygous familial hypercholesterolemia (HoFH) remain at very high cardiovascular risk despite the best standard of care lipid-lowering treatment. The addition evinacumab, an angiopoietin-like protein 3 monoclonal antibody, more than halves low-density lipoprotein cholesterol in short-term studies. This study evaluated whether evinacumab response was durable long term and improved outcome. METHODS: OLE ELIPSE HoFH (Open-Label Extension to Evinacumab Lipid Studies...
Mutations in the WFS1 gene have been reported Wolfram syndrome (WS), an autosomal recessive disorder defined by early onset of diabetes mellitus (DM) and progressive optic atrophy. Because low prevalence this recent identification gene, few data are available concerning relationships between clinical molecular aspects disease. Here, we describe 12 patients from 11 families with WS. We report on eight novel (A214fsX285, L293fsX303, P346L, I427S, V503fsX517, R558C, S605fsX711, P838L) seven...
Overproduction of intestinally derived apoB-48-containing triglyceride-rich lipoproteins (TRLs) (chylomicrons) has recently been described in type 2 diabetes, as is known for hepatic TRL-apoB-100 (very-low-density lipoprotein) production. Furthermore, insulin acutely inhibits both intestinal and TRL production, whereas this acute inhibitory effect on very-low-density lipoprotein production blunted diabetes. It not currently whether chylomicron similarly humans with diabetes.We investigated...
Objective— The dyslipidemia of obesity and other insulin-resistant states is characterized by the elevation plasma triglyceride-rich lipoproteins (TRL) both hepatic (apoB-100–containing very low-density lipoprotein) intestinal (apoB-48–containing chylomicrons) origin. Bariatric surgery a well-established effective modality for treatment associated with improvements in several metabolic abnormalities obesity, including reduction triglycerides. Here, we have investigated effect bariatric on...
Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through paracrine release proatherogenic mediators. Numerous works have analyzed inflammatory signature EAT, but scarce informations on its lipidome are available. Our objective was first study differences between EAT and subcutaneous (SAT) lipidomes second identify specific untargeted lipidomic signatures SAT in CAD. Approach Results: Subcutaneous...
Abstract Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting circulating lipoparticle metabolism (LDL, VLDL, chylomicrons, HDL) have recently been approved by the European and US medical agencies, including anti- proprotein convertase subtilisin/kexin 9 (PCSK9) antibodies; an siRNA PCSK9; bempedoic acid, which targets ATP citrate lyase; antisense oligonucleotide apolipoprotein C-III;...
Abstract Background The adiponectin is one of the rare adipokines down-regulated with obesity and protects against obesity-related disorders. Similarly, apolipoprotein M (apoM) expressed in adipocytes its expression adipose tissue associated metabolic health. We compared circulating apoM regarding their relationship parameters insulin sensitivity examined gene patterns tissue. Methods Circulating were 169 men overweight a cross-sectional study, 13 patients during surgery-induced slimming...