A5012472100- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ion Transport and Channel Regulation
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Erythrocyte Function and Pathophysiology
- Diet, Metabolism, and Disease
- Blood properties and coagulation
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological and metabolic disorders
- Peroxisome Proliferator-Activated Receptors
- Protease and Inhibitor Mechanisms
- Pharmacology and Obesity Treatment
- Health, Medicine and Society
- Diabetes Management and Education
- Botulinum Toxin and Related Neurological Disorders
- Advanced Glycation End Products research
- Antioxidant Activity and Oxidative Stress
- Biochemical effects in animals
Hôpital Sainte-Marguerite
2012-2024
Aix-Marseille Université
2007-2021
Centre de Résonance Magnétique Biologique et Médicale
2020-2021
Centre National de la Recherche Scientifique
2020-2021
Assistance Publique Hôpitaux de Marseille
1996-2019
Hyattsville Community Development Corporation
2018
Hôpital de la Conception
2015-2016
Inserm
2004-2015
Nutrition, Obésité et Risque Thrombotique
2004-2015
Institut National de la Recherche Agronomique
2015
Background Studies of the bacterial communities gut microbiota have revealed a shift in ratio Firmicutes and Bacteroidetes obese patients. Determining variations microbial feces may be beneficial for identification specific profiles patients with abnormal weights. The roles archaeon Methanobrevibacter smithii Lactobacillus species not been described these studies. Methods Findings We developed an efficient robust real-time PCR tool that includes plasmid-based internal control allows...
Obesity is associated with increased health risk and has been alterations in bacterial gut microbiota, mainly a reduction Bacteroidetes, but few data exist at the genus species level. It reported that Lactobacillus Bifidobacterium representatives may have critical role weight regulation as an anti-obesity effect experimental models humans, or growth-promoter agriculture depending on strains. To confirm test whether found human are obesity lean status, we analyzed stools of 68 obese 47...
To compare efficacy and safety of lixisenatide once daily versus exenatide twice in type 2 diabetes inadequately controlled with metformin.Adults (HbA1c 7-10%) metformin were randomized to 20 μg (n=318) or 10 (n=316) a 24-week (main period), open-label, parallel-group, multicenter study. The primary objective was noninferiority assessment HbA1c change from baseline week 24.Lixisenatide demonstrated reduction daily. least squares mean -0.79% (mean decrease 7.97 7.17%) for -0.96% 7.96 7.01%)...
To assess efficacy and safety of lixisenatide monotherapy in type 2 diabetes.Randomized, double-blind, 12-week study 361 patients not on glucose-lowering therapy (HbA(1c) 7-10%) allocated to one four once-daily subcutaneous dose increase regimens: 2-step (10 μg for 1 week, 15 then 20 μg; n = 120), 1-step weeks 119), placebo (n 61), or 61) (placebo groups were combined analyses). Primary end point was HbA(1c) change from baseline week 12.Once-daily significantly improved (mean 8.0%) both...
BackgroundClosed-loop insulin delivery systems are expected to become a standard treatment for patients with type 1 diabetes. We aimed assess whether the Diabeloop Generation (DBLG1) hybrid closed-loop artificial pancreas system improved glucose control compared sensor-assisted pump therapy.MethodsIn this multicentre, open-label, randomised, crossover trial, we recruited adults (aged ≥18 years) at least 2 year history of diabetes, who had been treated external therapy 6 months, glycated...
OBJECTIVE To compare the improvements in glycemic control associated with transitioning to insulin pump therapy patients using continuous glucose monitoring versus standard blood self-monitoring. RESEARCH DESIGN AND METHODS The RealTrend study was a 6-month, randomized, parallel-group, two-arm, open-label of 132 adults and children uncontrolled type 1 diabetes (A1C ≥8%) being treated multiple daily injections. One group fitted Medtronic MiniMed Paradigm REAL-Time system (PRT group), an...
A deficiency in essential fatty acid metabolism has been widely reported both human and animal diabetes. Fish oil supplementations (n-3 acids), containing docosahexaenoic (DHA) eicosapentaenoic (EPA), were less effective on diabetic neuropathy than (n-6) acids. This partial effect of (n-3) acids might be attributed to the presence EPA, a competitor arachidonic acid, which enhanced diabetes-induced decrease this serum tissues. For determining whether supplementation with DHA alone could...
The objective of this article is to evaluate the pharmacokinetics, efficacy and safety lixisenatide (subcutaneous injection) in elderly (≥65 years old) very (≥75 patients with type 2 diabetes mellitus.We conducted a phase I, single-centre, open-label study pharmacokinetics single 20 µg dose pooled analysis six randomized, placebo-controlled, III studies (12-month or 24-month duration) that evaluated glycaemic parameters receiving once daily placebo.The included 36 healthy subjects, including...
This study used data from different sources to identify the extent of unmet need for postprandial glycemic control in patients with type 2 diabetes mellitus (T2DM) after initiation basal insulin therapy Europe, Asia Pacific, United States, and Latin America.Different levels evidence were as available each country/region, extracted seven randomized controlled trials (RCTs), three clinical trial registries (CTRs), electronic medical record (EMR) databases. Glycemic status was categorized "well...
Taking into account how people value the healthiness and tastiness of food at both behavioral brain levels may help to better understand address overweight obesity-related issues. Here, we investigate whether activity in those areas involved self-control increase significantly when individuals with a high body-mass index (BMI) focus their attention on taste rather than health benefits related healthy choices. Under such conditions, BMI is positively correlated neural responses choices...