A5063848455- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Adenosine and Purinergic Signaling
- Diabetes Treatment and Management
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Genetic factors in colorectal cancer
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- Body Contouring and Surgery
- Diet and metabolism studies
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
Inserm
2021-2025
Hôpital de la Conception
2020-2025
Aix-Marseille Université
2020-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2022-2024
Hôpital Nord
2024
Délégation Provence et Corse
2023
Assistance Publique Hôpitaux de Marseille
2021
Abstract Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting circulating lipoparticle metabolism (LDL, VLDL, chylomicrons, HDL) have recently been approved by the European and US medical agencies, including anti- proprotein convertase subtilisin/kexin 9 (PCSK9) antibodies; an siRNA PCSK9; bempedoic acid, which targets ATP citrate lyase; antisense oligonucleotide apolipoprotein C-III;...
The aim of this study (EPIDIAB) was to assess the relationship between epicardial adipose tissue (EAT) and micro macrovascular complications (MVC) type 2 diabetes (T2D). EPIDIAB is a post hoc analysis from AngioSafe T2D study, which multicentric aimed at determining safety antihyperglycemic drugs on retina including patients with screened for diabetic retinopathy (DR) (n = 7200) deeply phenotyped MVC. Patients included who had undergone cardiac CT CAC (Coronary Artery Calcium) scoring after...
The aim of this study is to assess whether the family cascade screening strategy for identifying patients with heterozygous familial hypercholesterolaemia (HeFH) associated a reduction in cardiovascular events compared opportunistic strategies. We retrospectively included 3232 patients, from French FH registry, REFERCHOL, molecular diagnosis. according their HeFH: index cases (opportunistic screening) and (patients diagnosed by on clinical biological characteristics. first modality using χ²...
Animal studies have demonstrated that fetal exposure to high maternal cholesterol levels during pregnancy predisposes aortic atheroma in the offspring. In humans, little is known about consequences of this on development atherosclerotic cardiovascular disease later life. We wanted assess whether maternal/paternal inheritance familial hypercholesterolemia (FH) gene mutation could be associated with subclinical coronary atherosclerosis.We retrospectively included 1350 patients, followed French...
High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component plasma membranes and a regulator several signaling pathways, LDL-C excess may have wider cardiovascular toxicity. We examined, untreated hypercholesterolemia (HC) patients, selected regardless the cause accumulation, healthy participants (HP), expression adenosine A2A receptor (A2AR),...